Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

(2019) Hongxu Xian et al.   Nature Communications

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

Circadian rhythms in mitochondrial respiration

(2018) Paul de Goede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

(2018) Atsushi Miki et al.   PLoS One

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

BMAL1 functions as a cAMP-responsive coactivator of HDAC5 to regulate hepatic gluconeogenesis

(2018) Jian Li et al.   Protein & Cell

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial membrane potential identifies cells with high recombinant protein productivity

(2018) Lina Chakrabarti et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-α

(2017) Fuyuki Sato et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

(2017) Verónica Eisner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clock gene, brain and muscle Arnt-like 1, regulates autophagy in high glucose-induced cardiomyocyte injury

(2017) Li Qiao et al.   Oncotarget

Transcribing β-cell mitochondria in health and disease

(2017) Hindrik Mulder   Molecular Metabolism

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

(2016) Kuntol Rakshit et al.   DIABETOLOGIA

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

(2016) Xiaoyue Pan et al.   Nature Communications

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Liver Clock Protein BMAL1 Promotesde NovoLipogenesis through Insulin-mTORC2-AKT Signaling

(2014) Deqiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice

(2014) Akira Kohsaka et al.   PLoS One

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

(2013) Selma Masri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Uncoupling and reactive oxygen species (ROS) – A double-edged sword for β-cell function? “Moderation in all things”

(2012) Sheila Collins et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart

(2012) Kyriakos N. Papanicolaou et al.   CIRCULATION RESEARCH

The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus

(2012) Kalliopi I. Pappa et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Genome-Wide Profiling of the Core Clock Protein BMAL1 Targets Reveals a Strict Relationship with Metabolism

(2010) F. Hatanaka et al.   MOLECULAR AND CELLULAR BIOLOGY