Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

Hippocampal Ripple Coordinates Retrosplenial Inhibitory Neurons during Slow-Wave Sleep

(2020) Ashley N. Opalka et al.   Cell Reports

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

(2019) Feng Zhang et al.   Alzheimers & Dementia

Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature

(2019) Isabelle Guisle et al.   SLEEP

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

(2019) Jiyeon Lee et al.   AGING CELL

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sleep Disorders Associated With Alzheimer's Disease: A Perspective

(2018) Anna Brzecka et al.   Frontiers in Neuroscience

REM sleep behaviour disorder

(2018) Yves Dauvilliers et al.   Nature Reviews Disease Primers

Disruption of normal circadian clock function in a mouse model of tauopathy

(2017) Korey Stevanovic et al.   EXPERIMENTAL NEUROLOGY

Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte Dysfunction

(2017) Ryota Nakazato et al.   JOURNAL OF NEUROSCIENCE

Reciprocal changes in noradrenaline and GABA levels in discrete brain regions upon rapid eye movement sleep deprivation in rats

(2017) Rachna Mehta et al.   NEUROCHEMISTRY INTERNATIONAL

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

(2017) A. J. Ehrenberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Engrams and circuits crucial for systems consolidation of a memory

(2017) Takashi Kitamura et al.   SCIENCE

Neurodegeneration and the Circadian Clock

(2017) Suzanne Hood et al.   Frontiers in Aging Neuroscience

Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit

(2016) John P. Aggleton et al.   BRAIN

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice

(2016) Hongyan Qiu et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

(2015) Q. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

(2015) Hyundong Song et al.   Molecular Neurodegeneration

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese

(2015) Zhuqin Gu et al.   Scientific Reports

Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation

(2014) Sooyoung Chung et al.   CELL

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

(2014) Maria Bonmati-Carrion et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin feedback on clock genes: a theory involving the proteasome

(2014) Jerry Vriend et al.   JOURNAL OF PINEAL RESEARCH

Polymorphism of CLOCK Gene rs 4580704 C>G Is Associated with Susceptibility of Alzheimer’s Disease in a Chinese Population

(2013) Hai-feng Chen et al.   ARCHIVES OF MEDICAL RESEARCH

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Prevalence of Sleep Disturbances in Mild Cognitive Impairment and Dementing Disorders: A Multicenter Italian Clinical Cross-Sectional Study on 431 Patients

(2012) B. Guarnieri et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease

(2012) Marilyn J. Duncan et al.   EXPERIMENTAL NEUROLOGY

Changes in sleep theta rhythm are related to episodic memory impairment in early Alzheimer's disease

(2011) Pascal Hot et al.   BIOLOGICAL PSYCHOLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

REM sleep loss increases brain excitability: Role of noradrenalin and its mechanism of action

(2011) Birendra N. Mallick et al.   SLEEP MEDICINE REVIEWS

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

Étude des liens entre sommeil et mémoire épisodique chez le sujet jeune et âgé, et dans la maladie d’Alzheimer

(2010) G. Rauchs et al.   REVUE NEUROLOGIQUE

Obesity alters circadian expressions of molecular clock genes in the brainstem

(2009) Keizo Kaneko et al.   BRAIN RESEARCH

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

What does the retrosplenial cortex do?

(2009) Seralynne D. Vann et al.   NATURE REVIEWS NEUROSCIENCE

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease

(2008) N. Villain et al.   JOURNAL OF NEUROSCIENCE