Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Formulation of a stable water-in-oil nanoemulsion rich in anti-diabetic components of the roselle extract for controlled release

(2022) Roswanira Abdul Wahab et al.   CHEMICAL PAPERS

Anthocyanin: A Natural Dye Extracted from Hibiscus Sabdariffa (L.) for Textile and Dye Industries

(2022) Bharath Sankaralingam et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro

(2021) Justyna Siegień et al.   FOOD CHEMISTRY

Mechanisms of Action of Nutritionally Rich Hibiscus sabdariffa's Therapeutic Uses in Major Common Chronic Diseases: A Literature Review

(2021) Amylee Amos et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Mechanisms and Treatment of Dyslipidemia in Diabetes

(2021) Ehete Bahiru et al.   Current Cardiology Reports

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation

(2021) Shan-Kui Liu et al.   Frontiers in Chemistry

Comparative Efficacy and Safety of Ultra-Long-Acting, Long-Acting, Intermediate-Acting, and Biosimilar Insulins for Type 1 Diabetes Mellitus: a Systematic Review and Network Meta-Analysis

(2021) Andrea C. Tricco et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L.

(2021) Félix Leao Rodríguez-Fierros et al.   MOLECULES

Functional Food—Consumer Motivations and Expectations

(2021) Kinga Topolska et al.   International Journal of Environmental Research and Public Health

Hibiscus sabdariffa L. calyx extract prevents the adipogenesis of 3T3-L1 adipocytes, and obesity-related insulin resistance in high-fat diet-induced obese rats

(2021) Benjarat Janson et al.   BIOMEDICINE & PHARMACOTHERAPY

Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review

(2021) Navjot Kaur et al.   Chemical Biology & Drug Design

Network pharmacology-based analysis of the anti-hyperglycemic active ingredients of roselle and experimental validation

(2021) Bingxuan Niu et al.   COMPUTERS IN BIOLOGY AND MEDICINE

PPARs-Orchestrated Metabolic Homeostasis in the Adipose Tissue

(2021) Chen Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential of Hibiscus sabdariffa Linn. Polyphenol-Rich Extract in Improving Diabetes-Induced Vascular Functional and Structural Abnormalities in Rats

(2021) Fatin Farhana Jubaidi et al.   Sains Malaysiana

Effectiveness of a polyphenolic extract (Lippia citriodora and Hibiscus sabdariffa) on appetite regulation in overweight and obese grade I population: an 8-week randomized, double-blind, cross-over, placebo-controlled trial

(2021) Ana Serna et al.   EUROPEAN JOURNAL OF NUTRITION

Systematic Review of Medicinal Plants Used for Treatment of Diabetes in Human Clinical Trials: An ASEAN Perspective

(2021) Nazurah Hamizah Salleh et al.   Evidence-based Complementary and Alternative Medicine

The Antidiabetic and Antilipidemic Effects of Hibiscus Sabdariffa: A Systematic Review and Meta-analysis of Randomized Clinical Trials

(2020) Mohammed Bule et al.   FOOD RESEARCH INTERNATIONAL

Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes

(2020) Gordon C Weir et al.   Lancet Diabetes & Endocrinology

Insulin Therapy in Adults with Type 1 Diabetes Mellitus: a Narrative Review

(2020) Andrej Janež et al.   Diabetes Therapy

Role of gut microbiota in type 2 diabetes pathophysiology

(2020) Manoj Gurung et al.   EBioMedicine

Inflammatory Targets in Diabetic Nephropathy

(2020) Javier Donate-Correa et al.   Journal of Clinical Medicine

Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa, Genus Zizyphus, Hesperidin, Red Beetroot, Catha edulis, Portulaca oleracea, and Mulberry Leaves in the Treatment of Hypertension and Type 2 DM: A Comprehensive Review

(2020) Amira R. Amin et al.   Natural Product Communications

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress and diabetes: antioxidative strategies

(2020) Pengju Zhang et al.   Frontiers of Medicine

Lipase Inhibitors for Obesity: A Review

(2020) Tian-Tian Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Antihypertensive efficacy and safety of a standardized herbal medicinal product of Hibiscus sabdariffa and Olea europaea extracts ( NW Roselle): A phase‐II , randomized, double‐blind, captopril‐controlled clinical trial

(2020) Nabil Elkafrawy et al.   PHYTOTHERAPY RESEARCH

Action Mechanism of Rosella (Hibiscus sabdariffa L.) Used to Treat Metabolic Syndrome in Elderly Women

(2020) Yusni Yusni et al.   Evidence-based Complementary and Alternative Medicine

A review of the effectiveness of hibiscus for treatment of metabolic syndrome

(2020) Tia D. Jeffery et al.   JOURNAL OF ETHNOPHARMACOLOGY

Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity

(2019) Oyindamola Ojulari et al.   MOLECULES

Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies

(2019) Abraham Giacoman-Martínez et al.   PLANTA MEDICA

Acute Effects of Hibiscus Sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans

(2019) Salisu M. Abubakar et al.   Nutrients

Phytochemical Analysis, In vitro Antioxidant Activity and Inhibition of Key Diabetic Enzymes by Selected Nigerian Medicinal Plants with Antidiabetic Potential

(2019) Taofik Olatunde Sunmonu et al.   Indian Journal of Pharmaceutical Education and Research

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift

(2019) Christopher J Nolan et al.   Diabetes & Vascular Disease Research

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes

(2019) Emmanuel Ohifueme Alegbe et al.   JOURNAL OF FOOD BIOCHEMISTRY

Dyslipidemia management in diabetes

(2019) Julieta Lazarte et al.   Canadian Journal of Diabetes

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

(2019) Annabelle M. Warren et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Biomarkers for type 2 diabetes

(2019) Markku Laakso   Molecular Metabolism

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like Peptide-1 via SGLT-1 and GLPR in DM Rats

(2019) Neng Tine Kartinah et al.   Biomed Research International

The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity in mice

(2019) Patricia Diez-Echave et al.   FOOD RESEARCH INTERNATIONAL

Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis

(2019) Boxun Zhang et al.   PHYTOTHERAPY RESEARCH

Hibiscus sabdariffa (Roselle) Polyphenol-rich Extract Averts Cardiac Functional and Structural Abnormalities in Type 1 Diabetic Rats

(2018) Nur Liyana Mohammed Yusof et al.   Applied Physiology Nutrition and Metabolism

A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L.

(2018) Ghazala Riaz et al.   BIOMEDICINE & PHARMACOTHERAPY

Diabetes, cardiovascular disease and the microcirculation

(2018) W. David Strain et al.   Cardiovascular Diabetology

Diabetes in Childhood and Adolescence

(2018) Ralph Ziegler et al.   Deutsches Arzteblatt International

Comparative analysis of Hibiscus sabdariffa (roselle) hot and cold extracts in respect to their potential for α-glucosidase inhibition

(2018) Dalia M. Rasheed et al.   FOOD CHEMISTRY

Seasonal variation in Hibiscus sabdariffa (Roselle) calyx phytochemical profile, soluble solids and α-glucosidase inhibition

(2018) Idolo Ifie et al.   FOOD CHEMISTRY

Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice

(2018) Tae Wan Seung et al.   FOOD RESEARCH INTERNATIONAL

Antidiabetic Effect of Rosella-Stevia Tea on Prediabetic Women in Yogyakarta, Indonesia

(2018) Noor Rohmah Mayasari et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Hypoglycemic and hypolipidemic effects of fermented milks with added roselle ( Hibiscus sabdariffa L.) extract

(2018) Nana Su et al.   Journal of Functional Foods

Diabetes Mellitus and Infertility: Different Pathophysiological Effects in Type 1 and Type 2 on Sperm Function

(2018) Rosita A. Condorelli et al.   Frontiers in Endocrinology

Molecular pathways associated with oxidative stress in diabetes mellitus

(2018) Osasenaga Macdonald Ighodaro   BIOMEDICINE & PHARMACOTHERAPY

Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation

(2018) Young-Sil Lee et al.   Nutrients

Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex

(2018) Xinran Ma et al.   Frontiers in Endocrinology

Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review

(2017) Constanze C Maresch et al.   HUMAN REPRODUCTION UPDATE

Type 1 Diabetes Mellitus and Cognitive Impairments: A Systematic Review

(2017) Wei Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Type 2 diabetes

(2017) Sudesna Chatterjee et al.   LANCET

Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals

(2017) Mansour Sedighi et al.   MICROBIAL PATHOGENESIS

Clinical and pathological factors associated with progression of diabetic nephropathy

(2017) Shuang Liang et al.   NEPHROLOGY

Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

(2017) María Herranz-López et al.   Nutrients

Aqueous calyxes extract of Roselle or Hibiscus sabdariffa Linn supplementation improves liver morphology in streptozotocin induced diabetic rats

(2017) Akhtar Husin Nazratun Nafizah et al.   Arab Journal of Gastroenterology

Assessment of antioxidant properties, instrumental and sensory aroma profile of red and white Karkade/Roselle (Hibiscus sabdariffa L.)

(2017) Haroon Elrasheid Tahir et al.   Journal of Food Measurement and Characterization

Highlighting Diabetes Mellitus

(2017) Ann Marie Schmidt   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Liver glucose metabolism in humans

(2016) M. M. Adeva-Andany et al.   BIOSCIENCE REPORTS

Phytotherapy in reducing glycemic index and testicular oxidative stress resulting from induced diabetes: a review

(2016) J. S. Oliveira et al.   BRAZILIAN JOURNAL OF BIOLOGY

Diabetes and Cognitive Impairment

(2016) Lindsay A. Zilliox et al.   Current Diabetes Reports

Impact of gut microbiota on diabetes mellitus

(2016) G. Blandino et al.   DIABETES & METABOLISM

Diabetes mellitus and oxidative stress—A concise review

(2016) Ullah Asmat et al.   SAUDI PHARMACEUTICAL JOURNAL

Ocular Complications of Diabetes and Therapeutic Approaches

(2016) Victoria J. Vieira-Potter et al.   Biomed Research International

Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus

(2015) Zhi-Xu He et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Effect of stevia and citric acid on the stability of phenolic compounds and in vitro antioxidant and antidiabetic capacity of a roselle (Hibiscus sabdariffa L.) beverage

(2015) Iza F. Pérez-Ramírez et al.   FOOD CHEMISTRY

Diabetic Cardiovascular Disease Induced by Oxidative Stress

(2015) Yosuke Kayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roselle calyces (Hibiscus sabdariffa), an alternative to the food and beverages industries: a review

(2015) S. Cid-Ortega et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Hibiscus sabdariffacalyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats

(2015) Taofeek O Ajiboye et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Anthocyanin-rich extract fromHibiscus sabdariffacalyx counteracts UVC-caused impairments in rats

(2015) Hatice Uce Ozkol et al.   PHARMACEUTICAL BIOLOGY

Medicinal Plants Traditionally Used for Treatment of Obesity and Diabetes Mellitus - Screening for Pancreatic Lipase and α-Amylase Inhibition

(2015) Tina Buchholz et al.   PHYTOTHERAPY RESEARCH

Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia

(2015) Klaus G. Parhofer   Diabetes & Metabolism Journal

Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage

(2014) David O Adeyemi et al.   BMC Complementary and Alternative Medicine

PCOS in Adolescence and Type 2 Diabetes

(2014) Anne-Marie Carreau et al.   Current Diabetes Reports

Hibiscus sabdariffa L. – A phytochemical and pharmacological review

(2014) Inês Da-Costa-Rocha et al.   FOOD CHEMISTRY

Hibiscus sabdariffa Polyphenols Alleviate Insulin Resistance and Renal Epithelial to Mesenchymal Transition: A Novel Action Mechanism Mediated by Type 4 Dipeptidyl Peptidase

(2014) Chiung-Huei Peng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

(2014) S. O'Neill et al.   Obesity Reviews

Potencial terapéutico del Hibiscus sabdariffa: una revisión de las evidencias científicas

(2014) Soledad Guardiola et al.   Endocrinologia y Nutricion

The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes

(2013) J Mohamed et al.   Clinics

Are we overestimating the loss of beta cells in type 2 diabetes?

(2013) Lorella Marselli et al.   DIABETOLOGIA

Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: A comprehensive review of animal and human studies

(2013) Allison L. Hopkins et al.   FITOTERAPIA

Polyphenols of Hibiscus sabdariffa Improved Diabetic Nephropathy via Attenuating Renal Epithelial Mesenchymal Transition

(2013) Yi-Sun Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via regulating the pathogenic markers and kidney functions of type 2 diabetic rats

(2013) Yi-Sun Yang et al.   Journal of Functional Foods

In vitro inhibitory effects of plant-based foods and their combinations on intestinal α-glucosidase and pancreatic α-amylase

(2012) Sirichai Adisakwattana et al.   BMC Complementary and Alternative Medicine

Aqueous Extracts of Roselle (Hibiscus sabdariffa Linn.) Varieties Inhibit α-Amylase and α-Glucosidase Activities In Vitro

(2012) Adedayo O. Ademiluyi et al.   JOURNAL OF MEDICINAL FOOD

Gut microbiota and diabetes: from pathogenesis to therapeutic perspective

(2011) Rémy Burcelin et al.   ACTA DIABETOLOGICA

Chemopreventive Properties and Molecular Mechanisms of the Bioactive Compounds in Hibiscus Sabdariffa Linne

(2011) Hui-Hsuan Lin et al.   CURRENT MEDICINAL CHEMISTRY

Hibiscus sabdariffaPolyphenolic Extract Inhibits Hyperglycemia, Hyperlipidemia, and Glycation-Oxidative Stress while Improving Insulin Resistance

(2011) Chiung-Huei Peng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update

(2010) R. Tundis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Aqueous Extract fromHibiscus sabdariffaLinnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γin an Experimental Animal Model

(2009) Shou-Chieh Wang et al.   Evidence-based Complementary and Alternative Medicine

Hibiscus sabdariffa Inhibits Vascular Smooth Muscle Cell Proliferation and Migration Induced by High GlucoseA Mechanism Involves Connective Tissue Growth Factor Signals

(2009) Chien-Ning Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyphenol Extracts fromHibiscus sabdariffaLinnaeus Attenuate Nephropathy in Experimental Type 1 Diabetes

(2009) Wen-Chin Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Hypolipidemic Effect ofHibiscus sabdariffaPolyphenols via Inhibiting Lipogenesis and Promoting Hepatic Lipid Clearance

(2009) Mon-Yuan Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Sour Tea (Hibiscus sabdariffa) on Lipid Profile and Lipoproteins in Patients with Type II Diabetes

(2009) Hassan Mozaffari-Khosravi et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa

(2009) Deyanira Ojeda et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)

(2009) C.M. Gurrola-Díaz et al.   PHYTOMEDICINE

The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes

(2008) H Mozaffari-Khosravi et al.   JOURNAL OF HUMAN HYPERTENSION