Diabetic Cardiovascular Disease Induced by Oxidative Stress

N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

(2015) Cong Liu et al.   BMC Cardiovascular Disorders

Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development

(2015) U. Raaz et al.   CIRCULATION

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes MellitusNovelty and Significance

(2015) Uwe Raaz et al.   CIRCULATION RESEARCH

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling

(2015) Miles J. De Blasio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of coenzyme Q10supplementation on metabolic profile in diabetes: a systematic review and meta-analysis

(2015) N. Suksomboon et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Oxidative Stress and Early Atherosclerosis: Novel Antioxidant Treatment

(2014) Dimitris Tousoulis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

Medial vascular calcification revisited: review and perspectives

(2014) P. Lanzer et al.   EUROPEAN HEART JOURNAL

Probucol Prevents Atrial Remodeling by Inhibiting Oxidative Stress and TNF-α/NF-κB/TGF-β Signal Transduction Pathway in Alloxan-Induced Diabetic Rabbits

(2014) HUAYING FU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

Effect of Dietaryn-3Polyunsaturated Fatty Acids on Oxidant/Antioxidant Status in Macrosomic Offspring of Diabetic Rats

(2014) B. Guermouche et al.   Biomed Research International

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Hemodynamic Regulation of Reactive Oxygen Species: Implications for Vascular Diseases

(2013) Uwe Raaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective Effects ofd-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats

(2013) Ramakrishnan Murali et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Novel aspects of ROS signalling in heart failure

(2013) Anne D. Hafstad et al.   BASIC RESEARCH IN CARDIOLOGY

Production of Reactive Oxygen Species in the Diabetic Heart

(2013) Yasushi Teshima et al.   CIRCULATION JOURNAL

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Hypertension and Diabetes—A Toxic Combination

(2013) David Bell   Endocrine Practice

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

(2013) Karina Huynh et al.   FREE RADICAL BIOLOGY AND MEDICINE

TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis

(2013) Clemens Duerrschmid et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats

(2012) M. Pravenec et al.   AMERICAN JOURNAL OF HYPERTENSION

Redox Regulation of Sodium and Calcium Handling

(2012) Stefan Wagner et al.   ANTIOXIDANTS & REDOX SIGNALING

Interacting with Thioredoxin-1—Disease or No Disease?

(2012) Tim-Christian Zschauer et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials

(2012) Qianqian Wang et al.   ATHEROSCLEROSIS

Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats

(2012) Dhamodaran Prabakaran et al.   BIOCHIMIE

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Smooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification

(2012) Yong Sun et al.   CIRCULATION RESEARCH

The Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation on Biomarkers of Kidney Injury in Adults With Diabetes: Results of the GO-FISH trial

(2012) E. R. Miller et al.   DIABETES CARE

Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

(2012) K. Huynh et al.   DIABETOLOGIA

Association of Polymorphic Markers of the Catalase and Superoxide Dismutase Genes with Type 2 Diabetes Mellitus

(2012) Maivel H. Ghattas et al.   DNA AND CELL BIOLOGY

Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

(2012) In-Kyung Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Long-term streptozotocin-induced diabetes in rats leads to severe damage of brain blood vessels and neurons via enhanced oxidative stress

(2012) HONGYING YANG et al.   Molecular Medicine Reports

Elastin in Large Artery Stiffness and Hypertension

(2012) Jessica E. Wagenseil et al.   Journal of Cardiovascular Translational Research

Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

(2011) Bradley S. Fleenor et al.   AGING CELL

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

(2011) Rita M. Maalouf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Vascular Calcification and Aortic Fibrosis

(2011) Jian-Su Shao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells

(2011) Claudia Goettsch et al.   BASIC RESEARCH IN CARDIOLOGY

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

(2011) John R. Mercer et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats

(2011) A.S. Yar et al.   GENETICS AND MOLECULAR RESEARCH

Long-Term Probucol Treatment Prevents Secondary Cardiovascular Events: a Cohort Study of Patients with Heterozygous Familial Hypercholesterolemia in Japan

(2011) Shizuya Yamashita et al.   Journal of Atherosclerosis and Thrombosis

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Neurohormonal profile of patients with heart failure and diabetes

(2011) I. C. C. van der Horst et al.   Netherlands Heart Journal

Oxidative stress: a key contributor to diabetic cardiomyopathyThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Madhu Khullar et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Mitochondria in the diabetic heart

(2010) H. Bugger et al.   CARDIOVASCULAR RESEARCH

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus

(2010) Kristina I. Boström et al.   CIRCULATION RESEARCH

12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets

(2010) K. Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

(2010) Mohanraj Rajesh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Where are we with probucol: A new life for an old drug?

(2009) Shizuya Yamashita et al.   ATHEROSCLEROSIS

Elevated plasma levels of TNF-alpha and Interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders

(2009) Wilfried Dinh et al.   Cardiovascular Diabetology

High glucose sensitizes adult cardiomyocytes to ischaemia/reperfusion injury through nitrative thioredoxin inactivation

(2009) R. Luan et al.   CARDIOVASCULAR RESEARCH

Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries

(2009) Mei Y. Speer et al.   CIRCULATION RESEARCH

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

(2009) E. Shen et al.   DIABETES

Gene Deletion of the Kinin Receptor B1 Attenuates Cardiac Inflammation and Fibrosis During the Development of Experimental Diabetic Cardiomyopathy

(2009) D. Westermann et al.   DIABETES

Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure

(2009) Yosuke Kayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population

(2008) Kazuo Eguchi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages

(2008) Yeshao Wen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial oxidative stress and dysfunction in myocardial remodelling

(2008) H. Tsutsui et al.   CARDIOVASCULAR RESEARCH

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

(2008) C. D. A. Stehouwer et al.   DIABETOLOGIA

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species

(2008) Hideki Sumimoto   FEBS Journal

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats

(2008) Wenyuan Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Biomarkers in Heart Failure

(2008) Eugene Braunwald   NEW ENGLAND JOURNAL OF MEDICINE

Polyunsaturated fatty acids as antioxidants

(2008) D RICHARD et al.   PHARMACOLOGICAL RESEARCH

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

(2008) Stavros Selemidis et al.   PHARMACOLOGY & THERAPEUTICS

Uncomplicated type 1 diabetes and preclinical left ventricular myocardial dysfunction: Insights from echocardiography and exercise cardiac performance evaluation

(2007) Vittorio Palmieri et al.   DIABETES RESEARCH AND CLINICAL PRACTICE