Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex

Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline

(2018) Lingyan Xu et al.   AGING CELL

Genetic inhibition of PPARγ S112 phosphorylation reduces bone formation and stimulates marrow adipogenesis

(2018) Chunxi Ge et al.   BONE

Midlife weight gain is a risk factor for obesity-related cancer

(2018) Susan Chadid et al.   BRITISH JOURNAL OF CANCER

Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

(2018) Qiong A. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte

(2017) Andrea Armani et al.   FASEB JOURNAL

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

(2017) Yuta Hiraike et al.   NATURE CELL BIOLOGY

PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression

(2017) Irfan J. Lodhi et al.   Cell Reports

Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism

(2017) Kimberley D. Bruce et al.   Frontiers in Endocrinology

Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program

(2016) Mengle Shao et al.   Cell Metabolism

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

(2016) Barbara Gross et al.   Nature Reviews Endocrinology

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption

(2016) L.A. Stechschulte et al.   EBioMedicine

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specificUcp1gene through interactions with Mediator subunit MED1

(2015) Satoshi Iida et al.   GENES & DEVELOPMENT

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

(2015) Matthew J. Harms et al.   GENES & DEVELOPMENT

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition

(2015) Houari Abdesselem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans

(2015) Shana McCormack et al.   MITOCHONDRION

PRDM16 sustains white fat gene expression profile in human adipocytes in direct relation with insulin action

(2015) José María Moreno-Navarrete et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of Classical Brown Adipocytes in the Adult Human Perirenal Depot Is Highly Correlated with PRDM16–EHMT1 Complex Expression

(2015) Gaku Nagano et al.   PLoS One

Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis

(2015) Chang Liu et al.   Scientific Reports

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

(2015) Rafael Mayoral et al.   Molecular Metabolism

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Transcriptional Coregulators: Fine-Tuning Metabolism

(2014) Laurent Mouchiroud et al.   Cell Metabolism

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

(2014) Jang Hyun Choi et al.   GENES & DEVELOPMENT

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass

(2014) Vipula Kolli et al.   PLoS One

Role of forkhead box protein A3 in age-associated metabolic decline

(2014) Xinran Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

(2013) Claudio J. Villanueva et al.   Cell Metabolism

Fasting or caloric restriction for Healthy Aging

(2013) Stephen Anton et al.   EXPERIMENTAL GERONTOLOGY

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

(2013) Haruya Ohno et al.   NATURE

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

(2012) Nicole H. Rogers et al.   AGING CELL

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes

(2012) W. Zheng et al.   DIABETOLOGIA

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis

(2011) Sean M. Hartig et al.   JOURNAL OF CELL BIOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Aging alters PPARγ in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator-1

(2009) Stéphanie Miard et al.   AGING CELL

Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study

(2009) S.-M. Ruchat et al.   DIABETOLOGIA

PRDM16: the interconvertible adipo-myocyte switch

(2009) Gema Frühbeck et al.   TRENDS IN CELL BIOLOGY

Pparγ2 Is a Key Driver of Longevity in the Mouse

(2009) Carmen Argmann et al.   PLoS Genetics

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Molecular determinants of brown adipocyte formation and function

(2008) S. R. Farmer   GENES & DEVELOPMENT

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1 

(2008) A. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA