Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases

Carvone and its pharmacological activities: A systematic review

(2022) Lícia T.S. Pina et al.   PHYTOCHEMISTRY

Antioxidant Supplementation Hinders the Role of Exercise Training as a Natural Activator of SIRT1

(2022) Carmine Sellitto et al.   Nutrients

Longevity pharmacology comes of age

(2021) João Pedro de Magalhães   DRUG DISCOVERY TODAY

Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases

(2021) Sofia M. Lagoumtzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent Insights into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases

(2021) Feng Jiao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effect of genipin-1-β-d-gentiobioside on diabetic nephropathy in mice by activating AMP-activated protein kinase/silencing information regulator-related enzyme 1/ nuclear factor-κB pathway

(2021) Fengtao Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis

(2021) Na Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway

(2021) Bo Zou et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Health Benefits and Pharmacological Properties of Hinokitiol

(2021) Naoufal El Hachlafi et al.   Processes

Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line

(2021) Cátia Sousa et al.   Biomedicines

Iridoids: Research Advances in Their Phytochemistry, Biological Activities, and Pharmacokinetics

(2020) Congcong Wang et al.   MOLECULES

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

(2020) Jiahui Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity

(2020) Cátia Sousa et al.   Scientific Reports

Small molecule‐driven SIRT3‐autophagy mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes

(2020) Tian Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway

(2020) Fengtao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1 Activation by Natural Phytochemicals: An Overview

(2020) Concetta Iside et al.   Frontiers in Pharmacology

Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors

(2020) Milton Packer   Circulation-Heart Failure

Study on the inhibitive effect of Catalpol on diabetic nephropathy

(2020) Jing Chen et al.   LIFE SCIENCES

Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway

(2020) Wenshuai Ma et al.   Oxidative Medicine and Cellular Longevity

The long noncoding RNA MALAT1 suppresses miR‐211 to confer protection from ultraviolet‐mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1

(2020) H.D. Brahmbhatt et al.   BRITISH JOURNAL OF DERMATOLOGY

Impact of circadian disruption on health; SIRT1 and Telomeres

(2020) Meyrem Osum et al.   DNA REPAIR

The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception

(2020) Natalia Cappoli et al.   JOURNAL OF NEUROIMMUNOLOGY

Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways

(2020) Aimin Liu et al.   Bioengineered

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

(2020) Lorenzo Cuollo et al.   Biology-Basel

Evaluation of the immunomodulatory and anti-inflammatory activity of Bakuchiol using RAW 264.7 macrophage cell lines and in animal models stimulated by lipopolysaccharide (LPS)

(2020) Amit Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pterostilbene prevents hepatocyte EMT in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signaling

(2019) Lin Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells

(2019) Peng Kong et al.   NUCLEIC ACIDS RESEARCH

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

(2019) Rui Wang et al.   MOLECULES

Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

(2019) Yan-Xi Zhou et al.   Evidence-based Complementary and Alternative Medicine

Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia

(2019) Andrea Ticinesi et al.   Nutrients

Catalpol Alleviates Adriamycin‐Induced Nephropathy by Activating the SIRT1 Signalling Pathway In Vivo and In Vitro

(2019) Jiangnan Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of low-dose oleuropein diet supplementation on the oxidative status of skeletal muscles and plasma hormonal concentration of growing broiler chickens

(2019) R. Shimao et al.   BRITISH POULTRY SCIENCE

RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis

(2019) Se Kyu Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

(2019) Chiara Nediani et al.   Antioxidants

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

(2019) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

(2019) Subrat Kumar Bhattamisra et al.   Biomolecules

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

(2018) Yali Wang et al.   Oxidative Medicine and Cellular Longevity

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Protective effects of ex-527 on cerebral ischemia-reperfusion injury through necroptosis signaling pathway attenuation

(2018) Sara Nikseresht et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

(2018) Ning Li et al.   Frontiers in Pharmacology

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice

(2018) Hee-Kyung Hong et al.   GENES & DEVELOPMENT

Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis

(2018) Yunkai Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Paeoniflorin attenuates oxidized low‐density lipoprotein‐induced apoptosis and adhesion molecule expression by autophagy enhancement in human umbilical vein endothelial cells

(2018) Yi Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serum SIRT1 is Associated with Frailty and Adipokines in Older Adults

(2018) Lina Ma et al.   Journal of Nutrition Health & Aging

The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target

(2018) Lydia Brandl et al.   MEDICAL ONCOLOGY

Geniposide Protects against Obesity-Related Cardiac Injury through AMPKα- and Sirt1-Dependent Mechanisms

(2018) Zhen-Guo Ma et al.   Oxidative Medicine and Cellular Longevity

SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease

(2018) Yifei Zhong et al.   Frontiers in Endocrinology

The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia

(2017) Jing Huang et al.   Innate Immunity

Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice

(2017) Wenhao Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol

(2017) Ju-Hee Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death

(2017) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals

(2017) Niria Treviño-Saldaña et al.   Oxidative Medicine and Cellular Longevity

Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis

(2017) Yongjian Xiong et al.   PHARMACOLOGICAL RESEARCH

Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control

(2017) Jun-Kyu Shin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

(2017) So Youn Park et al.   Frontiers in Immunology

Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α

(2016) Motoi Kikusato et al.   ANIMAL SCIENCE JOURNAL

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

(2016) Michal Dudek et al.   ANNALS OF THE RHEUMATIC DISEASES

Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1

(2016) Jianyu Feng et al.   APOPTOSIS

Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

(2016) Wei Yang et al.   ENDOCRINOLOGY

Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways

(2016) Xiaolei Hu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study

(2016) Ilaria Luccarini et al.   JOURNAL OF ALZHEIMERS DISEASE

Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound

(2016) Shaoping Wu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mechanisms underlying the antiapoptotic and anti-inflammatory effects of monotropein in hydrogen peroxide-treated osteoblasts

(2016) Fang-Bing Zhu et al.   Molecular Medicine Reports

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

(2016) Rui-Hong Wang et al.   Scientific Reports

Disruption of Sirtuin 1–Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease

(2015) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Overview of the Pharmacological Properties and Potential Applications of Natural Monoterpenes

(2015) Agata Koziol et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway

(2015) B. Guo et al.   OSTEOARTHRITIS AND CARTILAGE

In vitro evidence for bakuchiol’s influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7

(2014) Y Xu et al.   African Health Sciences

SnapShot: Sirtuins, NAD, and Aging

(2014) Takashi Nakagawa et al.   Cell Metabolism

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

(2014) Marianne R. Smith et al.   HUMAN MOLECULAR GENETICS

Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: Involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway

(2014) QIUYAN WANG et al.   Molecular Medicine Reports

Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors

(2014) Nian Gong et al.   NEUROPHARMACOLOGY

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects

(2014) R. K. Chaudhuri et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Sirtuins in dermatology: applications for future research and therapeutics

(2013) Melissa Serravallo et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Citral Is Renoprotective for Focal Segmental Glomerulosclerosis by Inhibiting Oxidative Stress and Apoptosis and Activating Nrf2 Pathway in Mice

(2013) Shun-Min Yang et al.   PLoS One

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1

(2013) Marina M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage

(2013) Kyung-A Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Drugs that modulate aging: the promising yet difficult path ahead

(2013) Brian K. Kennedy et al.   Translational Research

Prospective Treatment of Age-Related Diseases by Slowing Down Aging

(2012) Mikhail V. Blagosklonny   AMERICAN JOURNAL OF PATHOLOGY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Core circadian protein CLOCK is a positive regulator of NF- B-mediated transcription

(2012) M. L. Spengler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol and life extension

(2011) Beamon Agarwal et al.   Annals of the New York Academy of Sciences

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Sirtuin 1 in immune regulation and autoimmunity

(2011) Sinyi Kong et al.   IMMUNOLOGY AND CELL BIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Sirtuin chemical mechanisms

(2010) Anthony A. Sauve   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study

(2010) D. G. Le Couteur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review

(2010) Maria Graça Miguel   MOLECULES

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Exercise Training Promotes SIRT1 Activity in Aged Rats

(2007) Nicola Ferrara et al.   REJUVENATION RESEARCH