The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia

Reappraisal to the study of 4E-BP1 as an mTOR substrate – A normative critique

(2017) Asiya Batool et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

Acute Lung Injury: A Clinical and Molecular Review

(2016) Yasmeen Butt et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

(2016) Yue Hu et al.   Autophagy

Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy

(2016) Adam Khader et al.   CRITICAL CARE MEDICINE

Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice

(2016) Xiaomin Wang et al.   EXPERIMENTAL CELL RESEARCH

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

(2016) Yujia Yuan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation

(2016) Shinji Toki et al.   THORAX

Tissue factor as a link between inflammation and coagulation

(2016) Marco Witkowski et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

(2016) Xiaolan Cui et al.   Cell Death & Disease

Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice

(2016) Zhao Yan et al.   Scientific Reports

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

(2016) Elizabeth E. Hull et al.   Biomed Research International

Myeloperoxidase Inhibitors as Potential Drugs

(2015) Tamara Lazarevic-Pasti et al.   CURRENT DRUG METABOLISM

Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

(2015) T. Zhao et al.   CURRENT MOLECULAR MEDICINE

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

(2015) SeungHye Han et al.   JOURNAL OF IMMUNOLOGY

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

(2015) Heyu Chen et al.   NEUROREPORT

Role of Tissue Factor in the Coagulation Network

(2015) Giovanni Cimmino et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression

(2015) Yuan Shen et al.   TRENDS IN PLANT SCIENCE

Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury

(2014) Yuping Jing et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

(2014) Sungki Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice

(2014) Andreas Rickenbacher et al.   JOURNAL OF HEPATOLOGY

Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis

(2014) Ting Zhao et al.   Journal of Trauma and Acute Care Surgery

mTOR and autophagy in regulation of acute lung injury: a review and perspective

(2014) Yue Hu et al.   MICROBES AND INFECTION

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

(2014) Nan Peng et al.   Scientific Reports

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

(2013) Xing Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling

(2013) Juan L. García-Rodríguez et al.   HEPATOLOGY

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma

(2012) TOMOMI ICHIKAWA et al.   RESPIROLOGY

The Biochemistry, Physiology and Pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo

(2012) Britt Van De Craen et al.   THROMBOSIS RESEARCH

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

(2011) Michel Bernier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice

(2010) Chong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease

(2009) So Ri Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Acetylation of MKP-1 and the Control of Inflammation

(2008) H. Chi et al.   Science Signaling

Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans

(2008) Elizabeth A. Sailhamer et al.   SURGERY