Health Benefits and Pharmacological Properties of Hinokitiol

Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration

(2021) Xueyang Jin et al.   Journal of Advanced Research

Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice

(2020) Takumi Hiyoshi et al.   ARCHIVES OF ORAL BIOLOGY

Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma

(2020) Chih-Chun Wang et al.   Taiwanese Journal of Obstetrics & Gynecology

Evaluation of Antibacterial Activity Expression of the Hinokitiol/Cyclodextrin Complex Against Bacteria

(2020) Yutaka Inoue et al.   ACS Omega

Chemical cross-linking on gelatin-hyaluronan loaded with hinokitiol for the preparation of guided tissue regeneration hydrogel membranes with antibacterial and biocompatible properties

(2020) Kai-Chi Chang et al.   Materials Science & Engineering C-Materials for Biological Applications

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

(2019) Guangya Zhang et al.   Cell Death & Disease

Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression

(2019) Kai-Che Wei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria predominant in the oral cavity and upper airways

(2019) Hisanori Domon et al.   MICROBIOLOGY AND IMMUNOLOGY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preparation, characterization, and study of the antimicrobial activity of a Hinokitiol-copper(II)/γ-cyclodextrin ternary complex

(2019) Rina Suzuki et al.   JOURNAL OF MOLECULAR STRUCTURE

Dynamic microstructural changes in alveolar bone in ligature‐induced experimental periodontitis

(2019) Ya-Hsin Wu et al.   Odontology

Natural Antibacterial Reagents (Centella, Propolis, and Hinokitiol) Loaded into Poly[(R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate] Composite Nanofibers for Biomedical Applications

(2019) Rina Afiani Rebia et al.   Nanomaterials

Characterization of genipin-crosslinked gelatin/hyaluronic acid-based hydrogel membranes and loaded with hinokitiol: In vitro evaluation of antibacterial activity and biocompatibility

(2019) Kai-Chi Chang et al.   Materials Science & Engineering C-Materials for Biological Applications

Antifungal effects of hinokitiol on development of Botrytis cinerea in vitro and in vivo

(2019) Ying Wang et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53

(2018) Jiun-Yi Li et al.   Archives of Medical Science

Hinokitiol Inhibits Migration of A549 Lung Cancer Cells via Suppression of MMPs and Induction of Antioxidant Enzymes and Apoptosis

(2018) Thanasekaran Jayakumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1

(2018) Y Chen et al.   POULTRY SCIENCE

New heterobimetallic ferrocenyl derivatives: Evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis

(2018) Feriannys Rivas et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New therapeutic strategy of hinokitiol in haemorrhagic shock‐induced liver injury

(2018) Wan‐Jung Lu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating mRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes

(2018) Krishnapriya Madhu Varier et al.   NEUROTOXICITY RESEARCH

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells

(2017) Xin Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Comparison of prolonged antibacterial activity and release profile of propolis-incorporated PVA nanofibrous mat, microfibrous mat, and film

(2017) Farideh Zeighampour et al.   JOURNAL OF APPLIED POLYMER SCIENCE

SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol

(2017) Ju-Hee Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells

(2017) Shih-Ming Chen et al.   Oncotarget

In Vitro and in Vivo Therapeutics of β-Thujaplicin on Lps-Induced Inflammation in Macrophages and Septic Shock in Mice

(2017) M-F. Shih et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The pharmacodynamics of antiplatelet compounds in thrombosis treatment

(2016) Thanasekaran Jayakumar et al.   Expert Opinion on Drug Metabolism & Toxicology

Physical characteristics, antimicrobial and odontogenesis potentials of calcium silicate cement containing hinokitiol

(2016) Ming-Hsien Huang et al.   Materials Science & Engineering C-Materials for Biological Applications

Hinokitiol inhibits vasculogenic mimicry activity of breast cancer stem/progenitor cells through proteasome-mediated degradation of epidermal growth factor receptor

(2016) DOM-GENE TU et al.   Oncology Letters

Hinokitiol-Loaded Mesoporous Calcium Silicate Nanoparticles Induce Apoptotic Cell Death through Regulation of the Function of MDR1 in Lung Adenocarcinoma Cells

(2016) Yu-Fang Shen et al.   Materials

Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1

(2016) Ji-Hong Moon et al.   Oncotarget

Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation

(2015) Chien-Hsun Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

(2015) J Ye et al.   EYE

Hinokitiol Exerts Anticancer Activity through Downregulation of MMPs 9/2 and Enhancement of Catalase and SOD Enzymes: In Vivo Augmentation of Lung Histoarchitecture

(2015) Chien-Hsun Huang et al.   MOLECULES

Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells

(2015) Po-Sheng Yang et al.   MOLECULES

Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments

(2015) Yun Chen et al.   VIRUS RESEARCH

Hinokitiol suppressed pan-histone expression and cell growth in oral squamous cell carcinoma cells

(2015) Yin-Hua Shih et al.   Journal of Functional Foods

Structure–activity relationships of the thujaplicins for inhibition of human tyrosinase

(2014) Atsushi Yoshimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hinokitiol induces autophagy in murine breast and colorectal cancer cells

(2014) Wei-Kuang Wang et al.   ENVIRONMENTAL TOXICOLOGY

Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo

(2014) Jin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antimalarial tropones and their Plasmodium falciparum glyoxalase I (pfGLOI) inhibitory activity

(2014) Aki Ishiyama et al.   JOURNAL OF ANTIBIOTICS

Application of hinokitiol potassium salt for wood preservative

(2014) Junyi Hu et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol In Vitro

(2014) Yin-Hua Shih et al.   PLoS One

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

(2013) Kuan H. Lin et al.   BIOCHEMICAL PHARMACOLOGY

Hinokitiol, a Natural Tropolone Derivative, Offers Neuroprotection from Thromboembolic StrokeIn Vivo

(2013) Thanasekaran Jayakumar et al.   Evidence-based Complementary and Alternative Medicine

In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines

(2013) Yin-Hua Shih et al.   MICROBIOLOGICAL RESEARCH

Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet

(2011) Junichiro ISHII et al.   ANIMAL SCIENCE JOURNAL

Cellular Mechanism of Zinc–Hinokitiol Complexes in Diabetes Mellitus

(2011) Yuki Naito et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Hinokitiol Inhibits Polyphenol Oxidase and Enzymatic Browning

(2011) Saya OKUMURA et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins

(2011) Shosuke Ito et al.   Pigment Cell & Melanoma Research

Effect of oral care gel on the quality of life for oral lichen planus in patients with chronic HCV infection

(2011) Yumiko Nagao et al.   Virology Journal

Time-Kill Assay Results for a Linalool-Hinokitiol-Based Eyelid Cleanser for Lid Hygiene

(2010) Jeffrey P Gilbard et al.   CORNEA

p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function

(2009) Shicheng Liu et al.   CANCER LETTERS

Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity

(2009) Maria Koufaki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antifungal Mechanism of Hinokitiol against Candida albicans

(2008) Nami Komaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

(2008) B. M. Krenn et al.   JOURNAL OF VIROLOGY

Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

(2008) Se Byeon et al.   PLANTA MEDICA