Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

(2018) Ching-Hou Ma et al.   Redox Biology

Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling

(2018) Shih-Hung Chan et al.   Redox Biology

Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis

(2017) Junjie Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

Homocysteine up-regulates endothelin type A receptor in vascular smooth muscle cells through Sirt1/ERK1/2 signaling pathway

(2017) Yulong Chen et al.   MICROVASCULAR RESEARCH

Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of Atherosclerosis

(2017) Junjie Zhao et al.   Journal of Stroke & Cerebrovascular Diseases

The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation

(2016) Mingcheng Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia

(2015) Ching-Hsia Hung et al.   CLINICAL SCIENCE

Picroside II Inhibits the MEK-ERK1/2-COX2 Signal Pathway to Prevent Cerebral Ischemic Injury in Rats

(2015) Tingting Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Picroside II protects rat kidney against ischemia/reperfusion-induced oxidative stress and inflammation by the TLR4/NF-κB pathway

(2015) LEI WANG et al.   Experimental and Therapeutic Medicine

Picroside II inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by ameliorating mitochondrial function through a mechanism involving a decrease in reactive oxygen species production

(2014) JIAN-ZHE LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging

(2013) María José Zarzuelo et al.   BIOCHEMICAL PHARMACOLOGY

Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia

(2013) Justine M. Abais et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

(2009) Koichi Sugimoto et al.   CARDIOVASCULAR RESEARCH

Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1

(2009) Jonathan Lu et al.   CIRCULATION RESEARCH

Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC

(2008) Miguel Romero et al.   ATHEROSCLEROSIS

Modulation of Angiotensin II–Mediated Hypertension and Cardiac Remodeling by Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Deletion

(2008) Changping Hu et al.   HYPERTENSION

New secoiridoid Glycosides from the Roots of Picrorhiza Scrophulariiflora

(2008) Lian-Chun Zou et al.   MOLECULES

Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression

(2007) Prajitha Thampi et al.   ATHEROSCLEROSIS