The c-MYC/NAMPT/SIRT1 feedback loop is activated in early classical and serrated route colorectal cancer and represents a therapeutic target

The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer

(2017) Martha L. Slattery et al.   GENES CHROMOSOMES & CANCER

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

(2017) Kaja C. G. Berg et al.   Molecular Cancer

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase

(2017) Li Q Zhang et al.   Cell Death & Disease

SIRT1 promotes epithelial–mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression

(2016) Feifei Cheng et al.   CANCER LETTERS

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

(2016) Catherine E. Bond et al.   Oncotarget

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

(2016) Anne-France Le Rolle et al.   Oncotarget

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

(2015) Deepak Sampath et al.   PHARMACOLOGY & THERAPEUTICS

c-MYC and SIRT1 locked in a vicious cycle

(2015)   Oncotarget

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer

(2015) Lydia Kriegl et al.   Oncotarget

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

(2014) D. Mouradov et al.   CANCER RESEARCH

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients

(2014) Xiaojing Chen et al.   Scientific Reports

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model

(2013) Vid Leko et al.   PLoS One

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

(2012) Z Wang et al.   ONCOGENE

Characteristics of Advanced- and Non Advanced Sporadic Polypoid Colorectal Adenomas: Correlation to KRAS Mutations

(2012) Enkh-Amar Yadamsuren et al.   PATHOLOGY & ONCOLOGY RESEARCH

Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool

(2011) Ying Feng et al.   GASTROENTEROLOGY

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

(2011) A. Menssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells

(2010) Ja-Eun Kim et al.   CELL CYCLE

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Sessile Serrated Adenoma (SSA) vs. Traditional Serrated Adenoma (TSA)

(2009) Emina Emilia Torlakovic et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Serrated Polyps and Colorectal Cancer: New Pathway to Malignancy

(2009) Amy E. Noffsinger   Annual Review of Pathology-Mechanisms of Disease

Cellular Regulation of SIRT1

(2009) Jo Milner   CURRENT PHARMACEUTICAL DESIGN

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer

(2009) Katsuhiko Nosho et al.   MODERN PATHOLOGY

Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/ -Catenin Pathway Activation

(2009) A. J. Finch et al.   MOLECULAR AND CELLULAR BIOLOGY

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE