Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of Amyotrophic lateral sclerosis

Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease

(2021) Manoj Govindarajulu et al.   NEUROCHEMISTRY INTERNATIONAL

Honokiol exerts protective effects on neural myelin sheaths after compressed spinal cord injury by inhibiting oligodendrocyte apoptosis through regulation of ER-mitochondrial interactions

(2021) Yong Tan et al.   JOURNAL OF SPINAL CORD MEDICINE

The diverse functionality of NQO1 and its roles in redox control

(2021) David Ross et al.   Redox Biology

Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer’s disease via inhibiting neuropathology and modulating gut microbiota

(2021) Chang Qu et al.   Journal of Advanced Research

Mitochondrial OMA1 and OPA1 as Gatekeepers of Organellar Structure/Function and Cellular Stress Response

(2021) Robert Gilkerson et al.   Frontiers in Cell and Developmental Biology

Role of Oxidative Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis: Antioxidant Metalloenzymes and Therapeutic Strategies

(2021) Pavlína Hemerková et al.   Biomolecules

The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS

(2021) Elena Obrador et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro

(2021) Yong Zhang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics

(2021) Shaoyong Zhuang et al.   PHARMACOLOGICAL RESEARCH

Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment

(2021) Francesca Pacifici et al.   Nutrients

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

(2021) Tanisha Singh et al.   Scientific Reports

Glutathione in the Nervous System as a Potential Therapeutic Target to Control the Development and Progression of Amyotrophic Lateral Sclerosis

(2021) Kiyoung Kim   Antioxidants

Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

(2021) Xiaoming Yang et al.   Antioxidants

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1 G93A mice

(2021) Silvia Scaricamazza et al.   BRITISH JOURNAL OF PHARMACOLOGY

Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

(2021) Mingyue Hou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis

(2021) Luyang Xiong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

(2021) Silvia Bono et al.   Molecular Neurodegeneration

Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System

(2021) Agnieszka Ścibior et al.   Oxidative Medicine and Cellular Longevity

Development of Nanosome-Encapsulated Honokiol for Intravenous Therapy Against Experimental Autoimmune Encephalomyelitis

(2020) Yai-Ping Hsiao et al.   International Journal of Nanomedicine

Heme-Oxygenase-1

(2020) María M. Facchinetti   ANTIOXIDANTS & REDOX SIGNALING

Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

(2020) Stéphanie Herkenne et al.   Cell Metabolism

Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein–Protein Interaction

(2020) Yong Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

(2020) Jin Wang et al.   Acta Pharmaceutica Sinica B

TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin β1 complex and regulating downstream FAK/RhoA signaling

(2020) Jingshu Tang et al.   Acta Pharmaceutica Sinica B

Effect of UVA radiation on the Nrf2 signalling pathway in human skin cells

(2020) Alena Ryšavá et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2020) John D. Lee et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment

(2020) Michele Longoni Calió et al.   Frontiers in Neuroscience

Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients

(2020) Ki Yoon Kim et al.   Translational Neurodegeneration

Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research

(2020) Beatriz Grisolia Araujo et al.   MOLECULAR NEUROBIOLOGY

Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

(2020) Elena Obrador et al.   Antioxidants

Honokiol Protects the Kidney from Renal Ischemia and Reperfusion Injury by Upregulating the Glutathione Biosynthetic Enzymes

(2020) Eun Jung Park et al.   Biomedicines

Molecular and Cellular Mechanisms Affected in ALS

(2020) Laura Le Gall et al.   Journal of Personalized Medicine

Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling

(2020) Yuqing Lin et al.   Frontiers in Immunology

Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts

(2020) Iraselia Garcia et al.   MITOCHONDRION

Honokiol Attenuates Sepsis-Associated Acute Kidney Injury via the Inhibition of Oxidative Stress and Inflammation

(2019) Shilin Xia et al.   INFLAMMATION

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

Epidemiology of amyotrophic lateral sclerosis

(2019) Elisa Longinetti et al.   CURRENT OPINION IN NEUROLOGY

Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal

(2019) Cristina Ribas Fürstenau et al.   NEUROTOXICITY RESEARCH

Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver

(2019) Feng-Ling Yu et al.   LIFE SCIENCES

Species‐specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1)

(2019) Alexandra C. E. Draper et al.   FASEB JOURNAL

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

(2019) Oliver H. Tam et al.   Cell Reports

Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

(2018) Yao Jin et al.   ACTA PHARMACOLOGICA SINICA

Neuroinflammation in Amyotrophic Lateral Sclerosis: Role of Redox (dys)Regulation

(2018) Nadia D'Ambrosi et al.   ANTIOXIDANTS & REDOX SIGNALING

The epidemiology and genetics of Amyotrophic lateral sclerosis in China

(2018) Xiaolu Liu et al.   BRAIN RESEARCH

Decreased glutathione levels cause overt motor neuron degeneration in hSOD1 WT over-expressing mice

(2018) Kelby M. Killoy et al.   EXPERIMENTAL NEUROLOGY

Protective and therapeutic activity of honokiol in reversing motor deficits and neuronal degeneration in the mouse model of Parkinson’s disease

(2018) Hwei-Hsien Chen et al.   Pharmacological Reports

Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation

(2018) Hwei-Hsien Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics

(2018) Jarosław Walczak et al.   FASEB JOURNAL

Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

(2018) Cristian Scatena et al.   Frontiers in Oncology

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2017) Aimee N. Winter et al.   NUTRITIONAL NEUROSCIENCE

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Comparison of human Nrf2 antibodies: A tale of two proteins

(2015) Zachary A. Kemmerer et al.   TOXICOLOGY LETTERS

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Comparative and Mechanistic Genotoxicity Assessment of Nanomaterials via a Quantitative Toxicogenomics Approach across Multiple Species

(2014) Jiaqi Lan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

(2014) N. Weiduschat et al.   NEUROSCIENCE LETTERS

Neuroprotective glucosides of magnolol and honokiol from microbial-specific glycosylation

(2014) Lin Yang et al.   TETRAHEDRON

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Defective Mitochondrial Dynamics Is an Early Event in Skeletal Muscle of an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Guo Luo et al.   PLoS One

Characterization of Wnt/β-catenin and BMP/Smad signaling pathways in an in vitro model of amyotrophic lateral sclerosis

(2013) Cristina Pinto et al.   Frontiers in Cellular Neuroscience

Neuro-Modulating Effects of Honokiol: A Review

(2013) Anna Woodbury et al.   Frontiers in Neurology

Impaired antioxydative Keap1/Nrf2 system and the downstream stress protein responses in the motor neuron of ALS model mice

(2012) Takafumi Mimoto et al.   BRAIN RESEARCH

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: A longitudinal MRI study

(2011) Stefania Marcuzzo et al.   EXPERIMENTAL NEUROLOGY

Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1G93A mice model

(2011) Marcelo R. Vargas et al.   NEUROBIOLOGY OF DISEASE

The Human G93A-Superoxide Dismutase-1 Mutation, Mitochondrial Glutathione and Apoptotic Cell Death

(2009) H. Muyderman et al.   NEUROCHEMICAL RESEARCH

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY