Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment
Authors
Keywords
-
Journal
Frontiers in Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-07-15
DOI
10.3389/fnins.2020.00679
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
- (2020) Nur Jury et al. Clinical Epigenetics
- TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis
- (2020) C. Appleby‐Mallinder et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective
- (2020) Manohar Kodavati et al. Cells
- The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS
- (2019) Ravinder Malik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development
- (2019) Xiaolong Chen et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model
- (2019) Elisabeth Rossaert et al. Acta Neuropathologica Communications
- Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring
- (2019) Mina Desai et al. NEUROSCIENCE
- Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice
- (2019) Claudia Figueroa-Romero et al. Disease Models & Mechanisms
- Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review
- (2019) Mariana Dutra Brito et al. Frontiers in Neurology
- Energy metabolism in ALS: an underappreciated opportunity?
- (2018) Tijs Vandoorne et al. ACTA NEUROPATHOLOGICA
- Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
- (2018) Hongbo Chen et al. CELL DEATH AND DIFFERENTIATION
- Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms
- (2018) Orietta Pansarasa et al. Disease Models & Mechanisms
- Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis
- (2018) Amit U Joshi et al. EMBO Molecular Medicine
- Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
- (2018) Nadee Nissanka et al. FEBS LETTERS
- Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair
- (2018) Elijah Koreman et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Characterization of the Mitochondrial Aerobic Metabolism in the Pre- and Perisynaptic Districts of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
- (2018) Silvia Ravera et al. MOLECULAR NEUROBIOLOGY
- TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
- (2018) Stephani A. Davis et al. NEUROSCIENCE LETTERS
- Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
- (2018) Souvarish Sarkar et al. NEUROTOXICOLOGY
- Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?
- (2018) Nathalie Bernard-Marissal et al. Cell Death & Disease
- Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning
- (2018) Eva Sidlauskaite et al. Redox Biology
- Parkin is a disease modifier in the mutant SOD1 mouse model of ALS
- (2018) Gloria M Palomo et al. EMBO Molecular Medicine
- Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis
- (2018) Annelies Nonneman et al. NEUROBIOLOGY OF DISEASE
- Evaluation of Chitotriosidase and CC-Chemokine Ligand 18 as Biomarkers of Microglia Activation in Amyotrophic Lateral Sclerosis
- (2018) Leyre Martinez-Merino et al. Neurodegenerative Diseases
- Epigenetic Changes Associated with the Expression of Amyotrophic Lateral Sclerosis (ALS) Causing Genes
- (2018) Alessandra Masala et al. NEUROSCIENCE
- FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models
- (2018) Jianwen Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations
- (2018) Andrea Stoccoro et al. Epigenomics
- Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
- (2018) Lorenzo Schiaffino et al. Scientific Reports
- Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS
- (2018) Noga Gershoni-Emek et al. Frontiers in Molecular Neuroscience
- Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
- (2018) Petra Frick et al. Acta Neuropathologica Communications
- Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease
- (2018) Seth A. Bennett et al. Translational Research
- Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis
- (2017) Hideyuki Sawada EXPERT OPINION ON PHARMACOTHERAPY
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Genetics insight into the amyotrophic lateral sclerosis/frontotemporal dementia spectrum
- (2017) Ai-Ling Ji et al. JOURNAL OF MEDICAL GENETICS
- Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor
- (2017) Chong Gao et al. MOLECULAR NEUROBIOLOGY
- The emerging field of epigenetics in neurodegeneration and neuroprotection
- (2017) Jee-Yeon Hwang et al. NATURE REVIEWS NEUROSCIENCE
- Mitochondrial quality control in amyotrophic lateral sclerosis: towards a common pathway?
- (2017) Bilal Khalil et al. Neural Regeneration Research
- Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support
- (2017) Samuel E. Marsh et al. NEUROCHEMISTRY INTERNATIONAL
- SIRT3 and mitochondrial metabolism in neurodegenerative diseases
- (2017) Illari Salvatori et al. NEUROCHEMISTRY INTERNATIONAL
- Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice
- (2017) Andrea Lapucci et al. NEUROSCIENCE LETTERS
- Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives
- (2017) F. Bozzo et al. NEUROSCIENCE LETTERS
- The role of mitochondria in amyotrophic lateral sclerosis
- (2017) Emma F. Smith et al. NEUROSCIENCE LETTERS
- The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring
- (2017) Zu-Hang Sheng TRENDS IN CELL BIOLOGY
- Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations
- (2017) Fabio Coppedè et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets
- (2017) et al. Genes
- Mitochondrial Dysfunction is a Converging Point of Multiple Pathological Pathways in Amyotrophic Lateral Sclerosis
- (2017) Ping Shi et al. JOURNAL OF ALZHEIMERS DISEASE
- Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis
- (2017) Paul E. Young et al. PLoS One
- Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
- (2017) Brianada Koentjoro et al. Scientific Reports
- ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain
- (2017) Boris I. Shneyer et al. Scientific Reports
- Pittsburgh compound B and other amyloid positron emission tomography tracers for the study of white matter and multiple sclerosis
- (2016) Jordi A. Matías-Guiu et al. ANNALS OF NEUROLOGY
- Metabolic reprogramming during neuronal differentiation
- (2016) M Agostini et al. CELL DEATH AND DIFFERENTIATION
- MicroRNA-125b regulates microglia activation and motor neuron death in ALS
- (2016) C Parisi et al. CELL DEATH AND DIFFERENTIATION
- CSPGs inhibit axon branching by impairing mitochondria-dependent regulation of actin dynamics and axonal translation
- (2016) Rajiv Sainath et al. Developmental Neurobiology
- Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
- (2016) Ting Yao et al. DIABETES
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion
- (2016) Brian Cunniff et al. MOLECULAR BIOLOGY OF THE CELL
- Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models
- (2016) Luana Naia et al. MOLECULAR NEUROBIOLOGY
- Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
- (2016) Wouter van Rheenen et al. NATURE GENETICS
- The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
- (2016) Wenzhang Wang et al. NATURE MEDICINE
- Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
- (2016) Rodrigo Lopez-Gonzalez et al. NEURON
- Mitochondria Localize to Injured Axons to Support Regeneration
- (2016) Sung Min Han et al. NEURON
- Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies
- (2016) Matthew Devall et al. NEUROSCIENCE LETTERS
- Methylation of C9orf72 expansion reduces RNA foci formation and dipeptide-repeat proteins expression in cells
- (2016) Peter O. Bauer NEUROSCIENCE LETTERS
- C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Demen
- (2016) Ruxandra Dafinca et al. STEM CELLS
- Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses
- (2016) Karpagam Srinivasan et al. Nature Communications
- Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders
- (2016) Erika G. Lin-Hendel et al. Cell Reports
- CHCHD10 is not a frequent causative gene in Chinese ALS patients
- (2016) Xiao Ling Li et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms
- (2016) Carolyn Hollands et al. Frontiers in Neuroscience
- Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts
- (2016) Elisa Onesto et al. Acta Neuropathologica Communications
- Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
- (2016) Junghee Lee et al. Experimental Neurobiology
- Mitochondrial DNA mutations in neurodegeneration
- (2015) Michael J. Keogh et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
- (2015) Senda Ajroud-Driss et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Therapeutic Development in Amyotrophic Lateral Sclerosis
- (2015) Monica Bucchia et al. CLINICAL THERAPEUTICS
- NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients
- (2015) Sonja Johann et al. GLIA
- The extracellular matrix compartment of neural stem and glial progenitor cells
- (2015) Andreas Faissner et al. GLIA
- The cognitive profile of ALS: a systematic review and meta-analysis update
- (2015) Emma Beeldman et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Epigenetic mechanisms in Parkinson's disease
- (2015) Ya Feng et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
- (2015) I Gijselinck et al. MOLECULAR PSYCHIATRY
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era
- (2015) Ximena Paez-Colasante et al. Nature Reviews Neurology
- Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex
- (2015) Eleonora Aronica et al. NEUROBIOLOGY OF DISEASE
- AMPK Signalling and Defective Energy Metabolism in Amyotrophic Lateral Sclerosis
- (2015) Nirma D. Perera et al. NEUROCHEMICAL RESEARCH
- SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis
- (2015) Francesco Tafuri et al. Frontiers in Cellular Neuroscience
- Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.
- (2015) Beate Winner et al. Cold Spring Harbor Perspectives in Biology
- Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis
- (2015) Sheng Chen et al. Neuroscience Bulletin
- Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells
- (2015) Fumito Endo et al. Cell Reports
- FUS Interacts with HSP60 to Promote Mitochondrial Damage
- (2015) Jianwen Deng et al. PLoS Genetics
- Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes
- (2014) Janet Cady et al. ANNALS OF NEUROLOGY
- Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression
- (2014) Jaclyn Nicole Le Grand et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Post-Translational Modifications of Histones That Influence Nucleosome Dynamics
- (2014) Gregory D. Bowman et al. CHEMICAL REVIEWS
- Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model
- (2014) Michele Longoni Calió et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1
- (2014) Michael Tibshirani et al. HUMAN MOLECULAR GENETICS
- Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts
- (2014) Luana Naia et al. MOLECULAR NEUROBIOLOGY
- The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes
- (2014) Hans-Georg König et al. NEUROBIOLOGY OF DISEASE
- Genetic Dys-regulation of Astrocytic Glutamate Transporter EAAT2 and its Implications in Neurological Disorders and Manganese Toxicity
- (2014) Pratap Karki et al. NEUROCHEMICAL RESEARCH
- Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
- (2014) Diane B. Re et al. NEURON
- Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G93A ALS mice: overlapping effects or limited therapeutic opportunity?
- (2014) Renzo Mancuso et al. Orphanet Journal of Rare Diseases
- Microglia centered pathogenesis in ALS: insights in cell interconnectivity
- (2014) Dora Brites et al. Frontiers in Cellular Neuroscience
- Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
- (2014) C Valle et al. Cell Death & Disease
- PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1
- (2014) Raquel Requejo-Aguilar et al. Nature Communications
- The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
- (2014) David B. Lovejoy et al. Frontiers in Aging Neuroscience
- Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1G93AMouse Model of Amyotrophic Lateral Sclerosis
- (2014) Lin Song et al. Biomed Research International
- Mitochondrial Translocation of p53 Modulates Neuronal Fate by Preventing Differentiation-Induced Mitochondrial Stress
- (2013) Joana M. Xavier et al. ANTIOXIDANTS & REDOX SIGNALING
- Neural stem cell survival factors
- (2013) Srinivas Ramasamy et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts
- (2013) Qiuli Liang et al. BIOCHEMICAL JOURNAL
- Mitochondrial genome changes and neurodegenerative diseases
- (2013) Milena Pinto et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression
- (2013) Gaëlle Bruneteau et al. BRAIN
- Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms
- (2013) Celine Perier et al. BRAIN
- Mitochondrial genetics
- (2013) P. F. Chinnery et al. BRITISH MEDICAL BULLETIN
- Sirtuins as therapeutic targets of ALS
- (2013) Giulio Maria Pasinetti et al. CELL RESEARCH
- Neuron-Specific Mitochondrial DNA Deletion Levels in Sporadic Alzheimer´s Disease
- (2013) Anne Gerschütz et al. Current Alzheimer Research
- Mitochondrial Fusion and Fission Proteins Expression Dynamically Change in a Murine Model of Amyotrophic Lateral Sclerosis
- (2013) Wentao Liu et al. CURRENT NEUROVASCULAR RESEARCH
- Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells
- (2013) Stefania Marcuzzo et al. EXPERIMENTAL NEUROLOGY
- Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
- (2013) Ines Taes et al. HUMAN MOLECULAR GENETICS
- Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
- (2013) Erica D. Koval et al. HUMAN MOLECULAR GENETICS
- The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
- (2013) Wenzhang Wang et al. HUMAN MOLECULAR GENETICS
- HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation
- (2013) Jozsef Gal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool
- (2013) Vito Iacobazzi et al. MOLECULAR GENETICS AND METABOLISM
- Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
- (2013) Shin H Kang et al. NATURE NEUROSCIENCE
- Pharmacological approaches to restore mitochondrial function
- (2013) Pénélope A. Andreux et al. NATURE REVIEWS DRUG DISCOVERY
- The epidemiology of ALS: a conspiracy of genes, environment and time
- (2013) Ammar Al-Chalabi et al. Nature Reviews Neurology
- Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats
- (2013) Maria Nikodemova et al. NEUROBIOLOGY OF DISEASE
- Neural Stem Cells: Generating and Regenerating the Brain
- (2013) Fred H. Gage et al. NEURON
- Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS
- (2013) Margaret Wong et al. Frontiers in Cellular Neuroscience
- Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
- (2013) C Parisi et al. Cell Death & Disease
- A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
- (2013) Isaac M. Chiu et al. Cell Reports
- Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset
- (2013) Lucio Tremolizzo et al. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- The genetics and neuropathology of amyotrophic lateral sclerosis
- (2012) Ammar Al-Chalabi et al. ACTA NEUROPATHOLOGICA
- SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
- (2012) Albert Giralt et al. BIOCHEMICAL JOURNAL
- Mitochondria: In Sickness and in Health
- (2012) Jodi Nunnari et al. CELL
- Mitochondrial Ca2+ and neurodegeneration
- (2012) Tito Calì et al. CELL CALCIUM
- Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
- (2012) Clifford D.L. Folmes et al. Cell Stem Cell
- Adult neurogenesis in Parkinson’s disease
- (2012) Franz Marxreiter et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Histone Deacetylation and Motor Neuron Degeneration
- (2012) S. Schmalbach et al. CNS & Neurological Disorders-Drug Targets
- Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench
- (2012) Tatiana R. Rosenstock et al. CURRENT DRUG TARGETS
- Amyotrophic lateral sclerosis
- (2012) Albert C. Ludolph et al. CURRENT OPINION IN NEUROLOGY
- Neural precursors (NPCs) from adult L967Q mice display early commitment to “in vitro” neuronal differentiation and hyperexcitability
- (2012) Francesca DiFebo et al. EXPERIMENTAL NEUROLOGY
- Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss inDrosophilaPTEN-induced Kinase 1 (PINK1) Null Mutant
- (2012) Hyongjong Koh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanistic insights into the regulation of metabolic enzymes by acetylation
- (2012) Yue Xiong et al. JOURNAL OF CELL BIOLOGY
- Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
- (2012) Oleg Butovsky et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons
- (2012) J. Magrane et al. JOURNAL OF NEUROSCIENCE
- Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
- (2012) Elisa Majounie et al. LANCET NEUROLOGY
- Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
- (2012) Zu-Hang Sheng et al. NATURE REVIEWS NEUROSCIENCE
- Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α
- (2012) Wenjun Song et al. NEUROBIOLOGY OF DISEASE
- Male-Specific Differences in Proliferation, Neurogenesis, and Sensitivity to Oxidative Stress in Neural Progenitor Cells Derived from a Rat Model of ALS
- (2012) Ruojia Li et al. PLoS One
- TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
- (2012) Y. Kawahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large Proportion of Amyotrophic Lateral Sclerosis Cases in Sardinia Due to a Single Founder Mutation of the TARDBP Gene
- (2011) Adriano Chiò ARCHIVES OF NEUROLOGY
- Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis
- (2011) Laura Ferraiuolo et al. BRAIN
- The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain
- (2011) Simone A. van den Berge et al. BRAIN
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis
- (2011) Jae Chul Lee et al. BRAIN RESEARCH
- G37R SOD1 mutant alters mitochondrial complex I activity, Ca2+ uptake and ATP production
- (2011) Evelyne Coussee et al. CELL CALCIUM
- Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis
- (2011) Young-Eun Yoo et al. EXPERIMENTAL NEUROLOGY
- Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
- (2011) Emily Foran et al. GLIA
- Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
- (2011) Miranda L. Tradewell et al. HUMAN MOLECULAR GENETICS
- Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration
- (2011) Oliver Trüe et al. IMMUNOLOGY AND CELL BIOLOGY
- Neurogenesis in Alzheimer’s disease
- (2011) José J. Rodríguez et al. JOURNAL OF ANATOMY
- Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation
- (2011) B. A. Chestnut et al. JOURNAL OF NEUROSCIENCE
- Nonmotor versus motor symptoms: How much do they matter to health status in Parkinson's disease?
- (2011) Claire Hinnell et al. MOVEMENT DISORDERS
- Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
- (2011) Amanda M Haidet-Phillips et al. NATURE BIOTECHNOLOGY
- Infection par le virus de l’immunodéficience humaine et diabète : vécu et qualité de vie des patients confrontés à deux maladies chroniques
- (2011) Caroline Henry et al. PRESSE MEDICALE
- Extraordinary neoteny of synaptic spines in the human prefrontal cortex
- (2011) Zdravko Petanjek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
- (2011) D. R. Green et al. SCIENCE
- Nonmotor manifestations of Parkinson's disease
- (2010) Tanya Simuni et al. ANNALS OF NEUROLOGY
- Mitochondrial Respiratory Chain Dysfunction in Muscle From Patients With Amyotrophic Lateral Sclerosis
- (2010) Veronica Crugnola et al. ARCHIVES OF NEUROLOGY
- Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
- (2010) Zacharias Kohl et al. BMC NEUROSCIENCE
- Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
- (2010) Koen Bossers et al. BRAIN
- Signaling in adult neurogenesis
- (2010) Yangling Mu et al. CURRENT OPINION IN NEUROBIOLOGY
- HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy
- (2010) Joo-Yong Lee et al. EMBO JOURNAL
- Glutamate-induced alterations in Ca2+ signaling are modulated by mitochondrial Ca2+ handling capacity in brain slices of R6/1 transgenic mice
- (2010) T. R. Rosenstock et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?
- (2010) A. Thompson et al. GENES BRAIN AND BEHAVIOR
- Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA
- (2010) Sang Hwa Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein homeostasis and aging in neurodegeneration
- (2010) Peter M. Douglas et al. JOURNAL OF CELL BIOLOGY
- Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis
- (2010) Claas Janssen et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Activity-Dependent Regulation of Mitochondrial Motility by Calcium and Na/K-ATPase at Nodes of Ranvier of Myelinated Nerves
- (2010) C. L. Zhang et al. JOURNAL OF NEUROSCIENCE
- Energy metabolism in amyotrophic lateral sclerosis
- (2010) Luc Dupuis et al. LANCET NEUROLOGY
- Mitochondrial dysfunction and intracellular calcium dysregulation in ALS
- (2010) Hibiki Kawamata et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Neuroglial Roots of Neurodegenerative Diseases?
- (2010) José Julio Rodríguez et al. MOLECULAR NEUROBIOLOGY
- Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
- (2010) Jessica M. Simpson et al. NEUROBIOLOGY OF DISEASE
- Neurocognitive signs in prodromal Huntington disease.
- (2010) Julie C. Stout et al. NEUROPSYCHOLOGY
- Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1
- (2010) V. Fedele et al. NEUROSCIENCE
- Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)
- (2010) Laura E. Cox et al. PLoS One
- Deficits in axonal transport precede ALS symptoms in vivo
- (2010) L. G. Bilsland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Energy metabolism in adult neural stem cell fate
- (2010) Victoria A. Rafalski et al. PROGRESS IN NEUROBIOLOGY
- Molecular Signals of Epigenetic States
- (2010) Roberto Bonasio et al. SCIENCE
- A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis
- (2009) Julia M. Morahan et al. Amyotrophic Lateral Sclerosis
- Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic Models of ALS
- (2009) Jose R. Sotelo-Silveira et al. ANTIOXIDANTS & REDOX SIGNALING
- Oligomerization of Mutant SOD1 in Mitochondria of Motoneuronal Cells Drives Mitochondrial Damage and Cell Toxicity
- (2009) Mauro Cozzolino et al. ANTIOXIDANTS & REDOX SIGNALING
- Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation
- (2009) D. M. Kirby et al. CELL PROLIFERATION
- Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
- (2009) Sai V. Seetharaman et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1
- (2009) Yongjie Yang et al. GLIA
- Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease
- (2009) Sebastian Mirochnic et al. HIPPOCAMPUS
- Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis
- (2009) M. Sabatelli et al. HUMAN MOLECULAR GENETICS
- Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
- (2009) J. Magrane et al. HUMAN MOLECULAR GENETICS
- Hyperactive Intracellular Calcium Signaling Associated with Localized Mitochondrial Defects in Skeletal Muscle of an Animal Model of Amyotrophic Lateral Sclerosis
- (2009) Jingsong Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
- (2009) Hristelina Ilieva et al. JOURNAL OF CELL BIOLOGY
- FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis
- (2009) I. P. Blair et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Dopaminergic Lesion Enhances Growth Factor-Induced Striatal Neuroblast Migration
- (2009) Beate Winner et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1
- (2009) Angel Herrero-Mendez et al. NATURE CELL BIOLOGY
- Epigenetic inheritance during the cell cycle
- (2009) Aline V. Probst et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice
- (2008) Steven J. Del Signore et al. Amyotrophic Lateral Sclerosis
- Epigenetics and the nervous system
- (2008) Mark F. Mehler ANNALS OF NEUROLOGY
- Inhibition of histone deacetylase1 induces autophagy
- (2008) Meeyeon Oh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Iron and calcium in the central nervous system: a close relationship in health and sickness
- (2008) Ilaria Pelizzoni et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Mechanisms and Functional Implications of Adult Neurogenesis
- (2008) Chunmei Zhao et al. CELL
- Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications
- (2008) L. Chin et al. CURRENT MEDICINAL CHEMISTRY
- Most mammalian mRNAs are conserved targets of microRNAs
- (2008) R. C. Friedman et al. GENOME RESEARCH
- Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
- (2008) Xuefei Wu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Expression of mutant SOD1G93Ain astrocytes induces functional deficits in motoneuron mitochondria
- (2008) Lynsey G. Bilsland et al. JOURNAL OF NEUROCHEMISTRY
- Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
- (2008) Xiangting Wang et al. NATURE
- Sirt1 contributes critically to the redox-dependent fate of neural progenitors
- (2008) Timour Prozorovski et al. NATURE CELL BIOLOGY
- Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
- (2008) Koji Yamanaka et al. NATURE NEUROSCIENCE
- Mitochondria in Neuroplasticity and Neurological Disorders
- (2008) Mark P. Mattson et al. NEURON
- Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation
- (2008) In Tag Yu et al. NEUROPHARMACOLOGY
- Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases
- (2008) N.Y. Calingasan et al. NEUROSCIENCE
- The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
- (2007) Qi Peng et al. EXPERIMENTAL NEUROLOGY
- Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
- (2007) Urs Rutishauser NATURE REVIEWS NEUROSCIENCE
- Adult neurogenesis is functionally associated with AD-like neurodegeneration
- (2007) Qian Chen et al. NEUROBIOLOGY OF DISEASE
- Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model
- (2007) Jose-Luis Gonzalez de Aguilar et al. PHYSIOLOGICAL GENOMICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started