Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Phiwayinkosi V. Dludla, Nireshni Chellan, Lawrence Mabasa, Jyoti R. Sharma, Rabia Johnson
Summary: The study found that DMSO concentrations lower than 0.5% can enhance respiratory control ratio and cellular viability in cardiomyoblasts, while exposure to 3.7% DMSO increases apoptosis in cardiomyoblasts due to mitochondrial dysfunction and oxidative stress. In cancer cells, DMSO at concentrations equal to or higher than 0.009 reduces maximal respiratory capacity and ATP-linked respiration, leading to increased ROS production and apoptosis. Surprisingly, 0.001% DMSO exposure resulted in increased proliferative activity in cancer cells. These findings suggest caution when using DMSO in cancer cells, while demonstrating no cytotoxic effects or therapeutic benefits at concentrations equal to or lower than 0.5% in cardiomyoblasts.
Article
Biochemistry & Molecular Biology
Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin
Summary: This study demonstrates rapid, specific and coordinated changes in cellular respiratory machinery, intermediary metabolism, and redox response in critically ill patients, with different trajectories in survivors and non-survivors. Differences in survival rates and metabolic activities were observed between survivors and non-survivors at 48 hours and day 7. Increases in oxidative stress and reductive drive were evident in critically ill patients, with non-survivors showing greater oxidative pressure and vascular inflammation compared to survivors.
Article
Biochemistry & Molecular Biology
Jonathan Hirschenson, Ryan J. Mailloux
Summary: The study demonstrates that glutathionylation can enhance ROS production by mitochondria, with different effects depending on the oxidizing sources and inhibitors used.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biology
Antoine Stier, Pat Monaghan, Neil B. Metcalfe
Summary: Variation in mitochondrial function among individuals may contribute to differences in individual performance and health state. It has been hypothesized that prenatal conditions could program postnatal mitochondrial function, with potential lasting effects. This study tested this hypothesis in birds by manipulating incubation temperature and stability, and found that high incubation temperature led to a consistent and long-lasting increase in mitochondrial aerobic metabolism. However, prenatal temperature conditions only explained a small proportion of the observed among-individual differences.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Sport Sciences
Erik D. Marchant, Nathan D. Marchant, Robert D. Hyldahl, Jayson R. Gifford, Michael W. Smith, Chad R. Hancock
Summary: This study aimed to investigate the effects of ultraendurance exercise on the bioenergetic status of muscle. The findings showed that completing a 100 km ultramarathon led to significant mitochondrial impairment in muscle, which rapidly recovered within two days. Blood markers also showed changes after the run but partially recovered within 48 hours.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Review
Cell Biology
Timothy Fabisiak, Manisha Patel
Summary: Neuroinflammation and oxidative stress play important roles in the pathophysiology of epilepsy. They have significant crosstalk and influence each other through various mechanisms, affecting epileptic processes and disease outcomes. Treatment strategies targeting oxidative stress and redox regulation may help control neuroinflammation and improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ravi A. Kumar, Trace Thome, Omar M. Sharaf, Terence E. Ryan, George J. Arnaoutakis, Eric Jeng, Leonardo F. Ferreira
Summary: Cardiomyocyte dysfunction in patients with end-stage heart failure with reduced ejection fraction is associated with mitochondrial dysfunction. Reversible thiol oxidation can modulate mitochondrial function, but other components of mitochondrial energy transfer are limiting factors in end-stage heart failure.
Article
Biochemistry & Molecular Biology
Vahid Ghanbarinejad, Mohammad M. Ommati, Zhipeng Jia, Omid Farshad, Akram Jamshidzadeh, Reza Heidari
Summary: The study investigated the impact of cholestasis on multiple organs, demonstrating impaired mitochondrial function in BDL animals. By evaluating mitochondrial glutathione redox state and tissue energy charge, the research revealed the underlying mechanisms of organ injury during cholestasis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Plant Sciences
Fernando Diego Kaziuk, Ana Luiza Dorigan de Matos Furlanetto, Andre Luis Wendt dos Santos, Eny Iochevet Senegal Floh, Lucelia Donatti, Maria Eliane Merlin Rocha, Fabiane Fortes, Glaucia Regina Martinez, Silvia Maria Suter Correia Cadena
Summary: This study evaluated the effects of temperature increase on the Araucaria angustifolia cell lines. Heat stress reduced cell viability and primarily affected mitochondria. Reactive oxygen species (ROS) levels increased in cells under heat stress, followed by a reduction after a certain time. Additionally, it was found that responsive cells were more efficient in modulating ROS levels.
FUNCTIONAL PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Neeru A. Vallabh, Jane Armstrong, Gabriela Czanner, Brian McDonagh, Anshoo Choudhary, David N. Criddle, Colin E. Willoughby
Summary: Glaucoma is a progressive optic neuropathy that leads to irreversible visual impairment and eventual blindness. The mitochondrial function of ocular fibroblasts in glaucoma patients is compromised, with elevated oxidative stress levels. Therapeutic interventions targeting oxidative stress or providing mitochondrial energetic support are important in managing glaucoma.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Saharnaz Sarlak, Claude Lalou, Ana Carolina B. Sant'Anna-Silva, Walid Mafhouf, Monica De Luise, Benoit Rousseau, Julien Izotte, Stephane Claverol, Didier Lacombe, Efterpi Nikitopoulou, Ming Yang, Marcus Oliveira, Christian Frezza, Giuseppe Gasparre, Hamid Reza Rezvani, Nivea Dias Amoedo, Rodrigue Rossignol
Summary: This study analyzes the effect of tobacco-specific nitrosamines on metabolic reprogramming in lung adenocarcinoma cells. The findings reveal that nicotine-derived nitrosamine ketone stimulates mitochondrial function, promoting lung tumor growth through a specific signaling pathway. Mitochondrial reactive oxygen species and Annexin A1 play key roles in tumor growth promotion.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Oncology
Marco Ponzetti, Argia Ucci, Chiara Puri, Luca Giacchi, Irene Flati, Daria Capece, Francesca Zazzeroni, Alfredo Cappariello, Nadia Rucci, Stefano Falone
Summary: This study investigated the effects of osteoblast-derived extracellular vesicles (OB-EVs) on the phenotype, energy metabolism, and oxidative status of osteosarcoma cells. The results showed that OB-EVs reduced the aggressiveness and viability of osteosarcoma cells through redox-dependent signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pamela A. Kakimoto, Julian David C. Serna, Vitor de Miranda Ramos, Antonio Zorzano, Alicia J. Kowaltowski
Summary: Exposure to toxic levels of fatty acids leads to cell damage and death, contributing to the pathogenesis of the metabolic syndrome. Lipotoxicity induces changes in mitochondrial morphology and increases glycolytic flux in cells, while oxidative phosphorylation remains unchanged.
Article
Biology
Linda Adzigbli, Eugene P. Sokolov, Siriluck Ponsuksili, Inna M. Sokolova
Summary: This study investigated the effects of hypoxia-reoxygenation (H/R) stress on oyster mitochondria and found that mitochondrial responses to stress varied depending on the substrate and mitochondrial activity state. Oysters exhibited metabolic adaptations to adjust to oxygen fluctuations and substrate availability during H/R, supporting rapid ATP resynthesis and mitigating oxidative stress.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Sport Sciences
Javier Gene-Morales, Andres Gene-Sampedro, Rosario Salvador-Palmer, Juan C. Colado
Summary: This study compared the acute adaptations of intraocular pressure, mean ocular perfusion pressure and central corneal thickness during squat exercise using elastic bands or weight plates. The results showed that both elastic bands and weight plates had significant effects on ocular and cardiovascular parameters, but had no significant effect on central corneal thickness. Elastic bands allowed for more repetitions compared to weight plates.
Article
Dentistry, Oral Surgery & Medicine
Omaya Amr-Rey, Purificacion Sanchez-Delgado, Rosario Salvador-Palmer, Rosa Cibrian, Vanessa Paredes-Gallardo
Summary: There is a significant association between dental malocclusion and speech disorders, as well as with oral habits and orofacial muscle activity. Malocclusions can cause imbalances in the functions of the stomatognathic system.
ANGLE ORTHODONTIST
(2022)
Article
Biology
Jose Ignacio Priego-Quesada, Ignacio Catala-Vilaplana, Jose Luis Bermejo-Ruiz, Alexis Gandia-Soriano, Maria Teresa Pellicer-Chenoll, Alberto Encarnacion-Martinez, Rosa Cibrian Ortiz de Anda, Rosario Salvador-Palmer
Summary: Skin temperature increases after a 10 km run at moderate intensity, peaking between 5 and 9 hours after exercise, but does not alter the thermal response to a cold stress test.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Elena Obrador, Rosario Salvador-Palmer, Blanca Pellicer, Rafael Lopez-Blanch, J. Antoni Sirerol, Juan I. Villaescusa, Alegria Montoro, Ryan W. Dellinger, Jose M. Estrela
Summary: The combination of natural polyphenols PT and SIL with radiomitigators NR and FSL1 can effectively protect animals from ionizing radiation.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Juan Villaescusa, Eduardo Gallego, Blanca Pellicer, Jose M. Estrela, Alegria Montoro
Summary: Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults, and the utilization of radiation exposure devices. Direct damage from radiation occurs through cellular interactions, while indirect effects result from reactive oxygen species generated by radiolysis of water molecules. Countermeasures for such crises should consider radiation type, affected individuals, dose range, and extent of exposure or contamination. Medical countermeasures, biodosimetry techniques, and response strategies are important in managing accidental radiation exposure.
Article
Oncology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Maria Oriol-Caballo, Paz Moreno-Murciano, Jose M. Estrela
Summary: Malignant melanoma, a cancer derived from melanocytes, can develop on skin, mucous membranes, and other locations. N-acetylcysteine (NAC), an antioxidant drug, may play a role in preventing cancer, but high doses could potentially cause metastatic spread of melanoma. Antioxidant properties of NAC and other promoters of glutathione synthesis should be used cautiously in cancer patients to avoid promoting metastatic growth.
Article
Biochemistry & Molecular Biology
Adrian Jorda, Martin Aldasoro, Ignacio Campo-Palacio, Jose M. Vila, Constanza Aldasoro, Juan Campos-Campos, Carlos Colmena, Sandeep Kumar Singh, Elena Obrador, Soraya L. Valles
Summary: Rn facilitates the effects of insulin on the p-AKT, p-eNOS, p-ERK, Mn-SOD, and PPAR-gamma signaling pathways, as well as on the anti-inflammatory and antioxidant effects of the hormone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Maria Oriol-Caballo, Paz Moreno-Murciano, Jose M. Estrela
Summary: Circulating glucocorticoids increase during stress and chronic stress leads to elevated levels of cortisol, which is associated with increased cancer risk and worse prognosis. Glucocorticoids can promote cancer growth and resistance to radiotherapy and chemotherapy. Knockdown of glucocorticoid receptors reduces antioxidant protection of melanoma cells and decreases their survival during interaction with the vascular endothelium.
Article
Biochemistry & Molecular Biology
Soraya L. Valles, Sandeep Kumar Singh, Juan Campos-Campos, Carlos Colmena, Ignacio Campo-Palacio, Kenia Alvarez-Gamez, Oscar Caballero, Adrian Jorda
Summary: In the central nervous system, glial cells outnumber neurons and possess a variety of functions. Astrocytes, radial glia, oligodendroglia, and microglia are different types of glial cells found in the CNS. Astrocytes play a crucial role, developing later than neurons and being involved in important functions such as memory and learning processes. They also contribute to CNS protection, communication between neurons, and maintenance of brain homeostasis. However, dysregulation of astrocyte function can lead to various neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Obrador, Alegria Montoro
Article
Oncology
Elena Obrador, Ali Jihad-Jebbar, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Maria Oriol-Caballo, Maria Paz Moreno-Murciano, Enrique A. Navarro, Rosa Cibrian, Jose M. Estrela
Summary: Moderate loco-regional hyperthermia can enhance the effects of chemotherapy and radiotherapy, as well as boost the immune response against cancer. However, higher temperatures can cause damage to healthy tissues and cancer cells show resistance to moderate hyperthermia. Combining hyperthermia with low-strength electromagnetic fields synergistically damages cancer cells and can be combined with other treatments for complete cancer eradication.