Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

(2021) Froukje Vanweert et al.   INTERNATIONAL JOURNAL OF OBESITY

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A

(2021) Jessica Cannavino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes

(2021) Valentina Pirro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

3-Hydroxyisobutyrate, a Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism

(2020) Mona S. Nilsen et al.   DIABETES

Branched-Chain Amino Acids and Branched-Chain Keto Acids in Hyperammonemic States: Metabolism and as Supplements

(2020) Milan Holeček   Metabolites

Exploring mechanistic links between extracellular BCAA & muscle insulin resistance: an in vitro approach

(2020) Hannah Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of low and high doses of fenofibrate on protein, amino acid, and energy metabolism in rat

(2020) Milan Holeček et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances

(2020) Froukje Vanweert et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

(2019) Qutuba G. Karwi et al.   Cardiovascular Diabetology

Role of branched-chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis

(2019) Dipsikha Biswas et al.   FASEB JOURNAL

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

(2019) Golam M. Uddin et al.   Cardiovascular Diabetology

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

(2019) Meiyi Zhou et al.   DIABETES

Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure

(2019) Mengping Chen et al.   Journal of the American Heart Association

Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

(2019) Yanislava Karusheva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

(2019) Steven Hamley et al.   DIABETOLOGIA

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats

(2019) Robert W. McGarrah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice

(2019) Kun Lian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gut microbiome and cardiometabolic risk

(2019) Ben Arpad Kappel et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose

(2018) Jordi Merino et al.   DIABETOLOGIA

Branched Chain Amino Acids: Beyond Nutrition Metabolism

(2018) Cunxi Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interaction between leucine and palmitate catabolism in 3T3-L1 adipocytes and primary adipocytes from control and obese rats

(2018) Daniela Salinas-Rubio et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism

(2018) Dawei Wang et al.   MEDICINE

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

Branched Chain Amino Acids in Metabolic Disease

(2018) Zoltan Arany et al.   Current Diabetes Reports

Branched Chain Amino Acids

(2018) Michael Neinast et al.   Annual Review of Physiology

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

FoxO Transcription Factors are Critical Regulators of Diabetes-Related Muscle Atrophy

(2018) Brian T. O’Neill et al.   DIABETES

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation

(2017) Olha Zhenyukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute effects of phenylbutyrate on glutamine, branched-chain amino acid and protein metabolism in skeletal muscles of rats

(2017) Milan Holecek et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Elevated α-Hydroxybutyrate and Branched-Chain Amino Acid Levels Predict Deterioration of Glycemic Control in Adolescents

(2017) Domenico Tricò et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

Branched-Chain Amino Acids and Brain Metabolism

(2017) Justin E. Sperringer et al.   NEUROCHEMICAL RESEARCH

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism

(2017) María Isabel Hernández-Alvarez et al.   Scientific Reports

Insulin does not stimulate muscle protein synthesis during increased plasma branched-chain amino acids alone but still decreases whole body proteolysis in humans

(2016) Sarah Everman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction

(2016) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program

(2016) Geoffrey A. Walford et al.   DIABETES

α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance

(2016) Jeff Cobb et al.   DIABETES CARE

Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: A twin study

(2016) Amy Jennings et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes

(2016) Yan Zheng et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A Cell-type-resolved Liver Proteome

(2016) Chen Ding et al.   MOLECULAR & CELLULAR PROTEOMICS

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance

(2016) M. J. A. Saad et al.   PHYSIOLOGY

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

(2016) Mee-Sup Yoon   Nutrients

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

(2016) Yoshinori Takeuchi et al.   Cell Reports

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

(2016) Luca A. Lotta et al.   PLOS MEDICINE

A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids

(2016) Nicole Landa Cavallaro et al.   Food & Nutrition Research

Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People

(2016) Maria Chondronikola et al.   Frontiers in Physiology

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

(2016) Carles Lerin et al.   Molecular Metabolism

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

(2015) Erin L. Glynn et al.   DIABETOLOGIA

Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis

(2015) Haitham Abdulla et al.   DIABETOLOGIA

Acylcarnitines: potential implications for skeletal muscle insulin resistance

(2015) Céline Aguer et al.   FASEB JOURNAL

Metabolomic Profile Associated With Insulin Resistance and Conversion to Diabetes in the Insulin Resistance Atherosclerosis Study

(2015) Nicholette D. Palmer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

The Impaired Function of Macrophages Induced by Strenuous Exercise Could Not Be Ameliorated by BCAA Supplementation

(2015) Weihua Xiao et al.   Nutrients

Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

(2015) Sulin Cheng et al.   PLoS One

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

(2014) April D. Lake et al.   AMINO ACIDS

Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits

(2014) Emma Watson et al.   CELL

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

(2014) Andrew C. Shin et al.   Cell Metabolism

4-Phenylbutyric Acid Increases GLUT4 Gene Expression through Suppression of HDAC5 but not Endoplasmic Reticulum Stress

(2014) Hailong Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice

(2014) Kun Lian et al.   DIABETES

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

(2014) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders

(2014) Lindsay C. Burrage et al.   MOLECULAR GENETICS AND METABOLISM

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Alloisoleucine differentiates the branched-chain aminoacidemia of Zucker and dietary obese rats

(2014) Kristine C. Olson et al.   Obesity

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity

(2014) In-Kyu Lee   Diabetes & Metabolism Journal

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

(2013) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

(2013) Anthony M. J. Sanchez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

(2013) Faidon Magkos et al.   DIABETES

Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial

(2013) Esther Phielix et al.   DIABETOLOGIA

Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics

(2013) Fengguo Xu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leucine and Protein Metabolism in Obese Zucker Rats

(2013) Pengxiang She et al.   PLoS One

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain  -ketoacid dehydrogenase kinase

(2013) S.-C. Tso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men

(2012) A. Stancakova et al.   DIABETES

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

(2012) A. Floegel et al.   DIABETES

Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance

(2012) E. Ferrannini et al.   DIABETES

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

A Novel Regulatory Defect in the Branched-Chain α-Keto Acid Dehydrogenase Complex Due to a Mutation in thePPM1KGene Causes a Mild Variant Phenotype of Maple Syrup Urine Disease

(2012) Alfonso Oyarzabal et al.   HUMAN MUTATION

Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing Endothelial Nitric Oxide Synthase in Healthy Normolipidemic Older Adults

(2012) Ashley E. Walker et al.   HYPERTENSION

Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)

(2012) Meiyi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State

(2012) Sean H. Adams   Advances in Nutrition

Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans

(2011) Martin O Weickert et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin resistance and the metabolism of branched-chain amino acids in humans

(2011) María M. Adeva et al.   AMINO ACIDS

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

(2011) Changting Xiao et al.   DIABETES

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Clofibrate-Induced Reduction of Plasma Branched-Chain Amino Acid Concentrations Impairs Glucose Tolerance in Rats

(2011) Yoshihiro Kadota et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Differential Metabolic Impact of Gastric Bypass Surgery Versus Dietary Intervention in Obese Diabetic Subjects Despite Identical Weight Loss

(2011) B. Laferrere et al.   Science Translational Medicine

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

(2010) Gene Hsiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of hepatic branched-chain α-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease

(2010) Masao Doisaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

(2010) E. S. Tai et al.   DIABETOLOGIA

Phenylbutyrate therapy for maple syrup urine disease

(2010) Nicola Brunetti-Pierri et al.   HUMAN MOLECULAR GENETICS

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

(2010) Mark A. Herman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response

(2010) Eva Klimčáková et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Isoleucine Prevents the Accumulation of Tissue Triglycerides and Upregulates the Expression of PPARα and Uncoupling Protein in Diet-Induced Obese Mice

(2010) Junko Nishimura et al.   JOURNAL OF NUTRITION

Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium

(2010) Jennifer Seminara et al.   MOLECULAR GENETICS AND METABOLISM

α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population

(2010) Walter E. Gall et al.   PLoS One

Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs

(2010) Tuija Leskinen et al.   PLoS One

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

(2010) Oliver Fiehn et al.   PLoS One

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

(2009) Y. Cheng et al.   DIABETES

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1 /Mitofusin-2 Regulatory Pathway in Response to Physical Activity

(2009) M. I. Hernandez-Alvarez et al.   DIABETES CARE

Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

(2009) K. M. Huffman et al.   DIABETES CARE

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

(2009) Gang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

(2009) Sean H. Adams et al.   JOURNAL OF NUTRITION

Decreased enzyme activity and contents of hepatic branched-chain α-keto acid dehydrogenase complex subunits in a rat model for type 2 diabetes mellitus

(2009) Gustavo Bajotto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Classical maple syrup urine disease and brain development: Principles of management and formula design

(2009) Kevin A. Strauss et al.   MOLECULAR GENETICS AND METABOLISM

Adverse effect of fenofibrate on branched-chain α-ketoacid dehydrogenase complex in rat's liver

(2009) Malgorzata Knapik-Czajka et al.   TOXICOLOGY

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

(2008) Kei Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

(2008) P. L. Greenhaff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus

(2008) Teiji Kuzuya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Cross-sectional multicenter study of patients with urea cycle disorders in the United States

(2008) Mendel Tuchman et al.   MOLECULAR GENETICS AND METABOLISM

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

(2007) Gijs H. Goossens   PHYSIOLOGY & BEHAVIOR