Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase

Branched-Chain Amino Acid Supplementation Reduces Oxidative Stress and Prolongs Survival in Rats with Advanced Liver Cirrhosis

(2013) Motoh Iwasa et al.   PLoS One

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain  -ketoacid dehydrogenase kinase

(2013) S.-C. Tso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Structural and Biochemical Characterization of Human Mitochondrial Branched-chain α-Ketoacid Dehydrogenase Phosphatase

(2012) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific and Nutrient Regulation of the Branched-chain α-Keto Acid Dehydrogenase Phosphatase, Protein Phosphatase 2Cm (PP2Cm)

(2012) Meiyi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

(2012) Anders Friberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds

(2012) Changguang Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors through Rational Design

(2011) Petr Čapek et al.   ACS Chemical Neuroscience

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase

(2011) Tanushree Banerjee et al.   IUBMB LIFE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Differential Metabolic Impact of Gastric Bypass Surgery Versus Dietary Intervention in Obese Diabetic Subjects Despite Identical Weight Loss

(2011) B. Laferrere et al.   Science Translational Medicine

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

(2010) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Phenylbutyrate therapy for maple syrup urine disease

(2010) Nicola Brunetti-Pierri et al.   HUMAN MOLECULAR GENETICS

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

(2009) K. M. Huffman et al.   DIABETES CARE

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

(2009) Gang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease

(2009) Kristen J Skvorak et al.   MOLECULAR THERAPY

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

(2008) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY