Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism

(2018) Tariq R. Altamimi et al.   BIOCHEMICAL JOURNAL

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking

(2018) E. Ramírez et al.   Cardiovascular Diabetology

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

(2018) Jeremy Pettus et al.   DIABETES OBESITY & METABOLISM

A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice

(2018) Annie Hasib et al.   PEPTIDES

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

(2018) Ankit X. Sharma et al.   Cell Reports

Cardiac Branched-Chain Amino Acid Oxidation is Reduced During Insulin Resistance in the Heart

(2018) Natasha Fillmore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Branched Chain Amino Acids in Metabolic Disease

(2018) Zoltan Arany et al.   Current Diabetes Reports

Empagliflozin lowers myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized 13 C magnetic resonance spectroscopy study

(2018) Desiree Abdurrachim et al.   DIABETES OBESITY & METABOLISM

Cardiac resynchronization therapy with a defibrillator (CRTd) in failing heart patients with type 2 diabetes mellitus and treated by glucagon-like peptide 1 receptor agonists (GLP-1 RA) therapy vs. conventional hypoglycemic drugs: arrhythmic burden, hospitalizations for heart failure, and CRTd responders rate

(2018) Celestino Sardu et al.   Cardiovascular Diabetology

Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction

(2016) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders

(2016) Gary D. Lopaschuk   ANNALS OF NUTRITION AND METABOLISM

Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure

(2016) Arata Fukushima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

(2016) Ele Ferrannini et al.   DIABETES CARE

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137

(2016) Qutuba G. Karwi et al.   PHARMACOLOGICAL RESEARCH

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

(2015) Erin L. Glynn et al.   DIABETOLOGIA

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

(2015) Safina Ali et al.   Molecular Metabolism

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart

(2014) Ling Lai et al.   Circulation-Heart Failure

Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts

(2014) Brian E. Sansbury et al.   Circulation-Heart Failure

Lowering Body Weight in Obese Mice With Diastolic Heart Failure Improves Cardiac Insulin Sensitivity and Function: Implications for the Obesity Paradox

(2014) Sowndramalingam Sankaralingam et al.   DIABETES

Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism

(2014) Domenick A. Prosdocimo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4

(2013) Jun Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

(2013) Waleed G.T. Masoud et al.   CARDIOVASCULAR RESEARCH

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

(2013) Wang Wang et al.   Journal of the American Heart Association

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

(2012) John R. Ussher et al.   CARDIOVASCULAR RESEARCH

Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload

(2012) Pavel Zhabyeyev et al.   CARDIOVASCULAR RESEARCH

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation

(2012) Jun Mori et al.   Circulation-Heart Failure

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Regulation of Cardiac Gene Expression by KLF15, a Repressor of Myocardin Activity

(2010) Joost J. Leenders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abdominal Subcutaneous and Visceral Adipose Tissue and Insulin Resistance in the Framingham Heart Study

(2010) Sarah R. Preis et al.   Obesity

Klf15 Deficiency Is a Molecular Link Between Heart Failure and Aortic Aneurysm Formation

(2010) S. M. Haldar et al.   Science Translational Medicine

Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion

(2009) John R. Ussher et al.   BASIC RESEARCH IN CARDIOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys

(2009) H. Yan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Body Mass Index and Vigorous Physical Activity and the Risk of Heart Failure Among Men

(2008) Satish Kenchaiah et al.   CIRCULATION

AMP-activated protein kinase control of energy metabolism in the ischemic heart

(2008) G D Lopaschuk   INTERNATIONAL JOURNAL OF OBESITY