Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

(2022) Joana Nogueira-Rodrigues et al.   DEVELOPMENTAL CELL

Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion

(2022) Ilyas M. Kabdesh et al.   Frontiers in Cellular Neuroscience

Endocrine Therapy for the Functional Recovery of Spinal Cord Injury

(2021) Hui Wang et al.   Frontiers in Neuroscience

Prosaposin mediates inflammation in atherosclerosis

(2021) Mandy M. T. van Leent et al.   Science Translational Medicine

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

(2021) Shamik Mascharak et al.   SCIENCE

Emerging Role of PD-1 in the Central Nervous System and Brain Diseases

(2021) Junli Zhao et al.   Neuroscience Bulletin

Fibroblasts: Origins, definitions, and functions in health and disease

(2021) Maksim V. Plikus et al.   CELL

A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord

(2021) Leonardo Cavone et al.   DEVELOPMENTAL CELL

Overexpression of bone morphogenetic protein 7 reduces oligodendrocytes loss and promotes functional recovery after spinal cord injury

(2021) Shuxin Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord

(2021) Lindsay M. Milich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploring tissue architecture using spatial transcriptomics

(2021) Anjali Rao et al.   NATURE

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Diet-regulated production of PDGFcc by macrophages controls energy storage

(2021) Nehemiah Cox et al.   SCIENCE

JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models

(2021) Michelle F. Griffin et al.   Science Translational Medicine

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

(2021) David O. Dias et al.   Nature Communications

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

(2021) Jie Wang et al.   CELL

EASI-FISH for thick tissue defines lateral hypothalamus spatio-molecular organization

(2021) Yuhan Wang et al.   CELL

Exercise plasma boosts memory and dampens brain inflammation via clusterin

(2021) Zurine De Miguel et al.   NATURE

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

(2021) Zijian Xu et al.   NATURE

Locomotor recovery after spinal cord injury: intimate dependence between axonal regeneration and re-connection

(2021) HectorRamiro Quinta   Neural Regeneration Research

Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury

(2021) Anissa Elahi et al.   Cells

Biodegradable Materials and the Tissue Engineering of Nerves

(2021) Xiaosong Gu   Engineering

Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury

(2020) Fan-Qi Kong et al.   Journal of Neuroinflammation

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

(2020) Xiang Zhou et al.   NATURE NEUROSCIENCE

Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates

(2020) Susan L. Lindsay et al.   Nature Reviews Neurology

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation

(2020) Dezun Ma et al.   BIOMATERIALS

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

(2020) Tuo Yang et al.   Frontiers in Cellular Neuroscience

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

(2020) Mar Puigdellívol et al.   Frontiers in Cellular Neuroscience

Molecular atlas of the adult mouse brain

(2020) Cantin Ortiz et al.   Science Advances

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

(2020) Anam Anjum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia-organized scar-free spinal cord repair in neonatal mice

(2020) Yi Li et al.   NATURE

Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia

(2020) Jing Wang et al.   NEURON

Exploring the Role of CLU in the Pathogenesis of Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   NEUROTOXICITY RESEARCH

A latent lineage potential in resident neural stem cells enables spinal cord repair

(2020) Enric Llorens-Bobadilla et al.   SCIENCE

Reversion of Injured Adult Neurons to an Embryonic State by Grafts of Neural Progenitor Cells After Spinal Cord Injury

(2020) Liying Cao et al.   Neuroscience Bulletin

Treatment of spinal cord injury with mesenchymal stem cells

(2020) Ling Ling Liau et al.   Cell and Bioscience

Association of CLU gene polymorphism with Parkinson's disease in the Chinese Han population

(2020) Yuwan Lin et al.   JOURNAL OF GENE MEDICINE

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury

(2020) Yaming Yang et al.   BIOMATERIALS

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

(2019) Arsalan Alizadeh et al.   Frontiers in Neurology

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Involvement of SAPK/JNK Signaling Pathway in Copper Enhanced Zinc-Induced Neuronal Cell Death

(2019) Ken-Ichiro Tanaka et al.   TOXICOLOGICAL SCIENCES

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

(2019) Chee-Huat Linus Eng et al.   NATURE

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord

(2019) Jia‐Sheng Rao et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Spinal cord repair: advances in biology and technology

(2019) Grégoire Courtine et al.   NATURE MEDICINE

Probabilistic cell typing enables fine mapping of closely related cell types in situ

(2019) Xiaoyan Qian et al.   NATURE METHODS

The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats

(2019) Bin Yu et al.   Frontiers in Molecular Neuroscience

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

(2019) Michaela Asp et al.   CELL

The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse

(2018) Katyayani Singh et al.   BRAIN RESEARCH BULLETIN

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations

(2018) Bo Chen et al.   CELL

Galectin-3: mediator of microglia responses in injured brain

(2018) Reza Rahimian et al.   DRUG DISCOVERY TODAY

Inhibition of CD36 reduces visceral fat accumulation and improves insulin resistance in diet-induced obese BDNFVal66Metmice

(2018) Jiwon Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffusion tensor imaging of spinal cord parenchyma lesion in rat with chronic spinal cord injury

(2018) Can Zhao et al.   MAGNETIC RESONANCE IMAGING

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

(2018) Magdolna Djurec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury

(2018) Jia-Sheng Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

(2018) Xiao Wang et al.   SCIENCE

Gene expression profiling of periodontitis-affected gingival tissue by spatial transcriptomics

(2018) Anna Lundmark et al.   Scientific Reports

Chemical conversion of human and mouse fibroblasts into motor neurons

(2018) Hua Qin et al.   Science China-Life Sciences

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections

(2018) Fredrik Salmén et al.   Nature Protocols

Preparation of plant tissue to enable Spatial Transcriptomics profiling using barcoded microarrays

(2018) Stefania Giacomello et al.   Nature Protocols

Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes

(2018) Eleftherios I. Paschalis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

(2018) Yan Zhang et al.   BRAIN RESEARCH

Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair

(2017) Hal X. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex

(2017) Paolo Bazzigaluppi et al.   NEUROBIOLOGY OF DISEASE

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Thrombospondin-1 modified bone marrow mesenchymal stem cells (BMSCs) promote neurite outgrowth and functional recovery in rats with spinal cord injury

(2017) Yujie Pu et al.   Oncotarget

Spatial detection of fetal marker genes expressed at low level in adult human heart tissue

(2017) Michaela Asp et al.   Scientific Reports

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

(2017) Yilong Ren et al.   Scientific Reports

Serum protein changes in a rat model of chronic pain show a correlation between animal and humans

(2017) Elisa Bellei et al.   Scientific Reports

The biological function and significance of CD74 in immune diseases

(2016) Huiting Su et al.   INFLAMMATION RESEARCH

Protective effects of BMP-7 against tumor necrosis factor α-induced oligodendrocyte apoptosis

(2016) Xin Wang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury

(2016) Arsalan Alizadeh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension

(2016) HAN WU et al.   Molecular Medicine Reports

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

(2016) Danyang He et al.   NATURE NEUROSCIENCE

The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis

(2016) Song Wang et al.   NEUROCHEMICAL RESEARCH

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

(2016) Takao Omura et al.   NEURON

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method

(2016) Thomas Liebmann et al.   Cell Reports

Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells

(2015) Prasanth Puthanveetil et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin

(2015) Kaia Achim et al.   NATURE BIOTECHNOLOGY

Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

(2015) Xin Duan et al.   NEURON

Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice

(2015) Marc A. DePaul et al.   PLoS One

The protective role of prosaposin and its receptors in the nervous system

(2014) Rebecca C. Meyer et al.   BRAIN RESEARCH

CD36 deletion improves recovery from spinal cord injury

(2014) Scott A. Myers et al.   EXPERIMENTAL NEUROLOGY

Ephrin-A3 reverse signaling regulates hippocampal neuronal damage and astrocytic glutamate transport after transient global ischemia

(2014) Jinshan Yang et al.   JOURNAL OF NEUROCHEMISTRY

Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration

(2014) M. C. Wright et al.   JOURNAL OF NEUROSCIENCE

Astroglial-Derived Periostin Promotes Axonal Regeneration after Spinal Cord Injury

(2014) C.-H. Shih et al.   JOURNAL OF NEUROSCIENCE

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

(2014) Florian Kahles et al.   Molecular Metabolism

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

(2013) C. Soderblom et al.   JOURNAL OF NEUROSCIENCE

In situ sequencing for RNA analysis in preserved tissue and cells

(2013) Rongqin Ke et al.   NATURE METHODS

Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner

(2012) Yi Bao et al.   ATHEROSCLEROSIS

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

(2012) R. van den Brand et al.   SCIENCE

Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts

(2011) Lucia Micutkova et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells

(2010) Mansoor Ahmed et al.   Molecular Cancer

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

(2009) Stefania Ceruti et al.   BRAIN

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Osteopontin: Role in immune regulation and stress responses

(2008) Kathryn X. Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Transcriptomic Screening of Microvascular Endothelial Cells Implicates Novel Molecular Regulators of Vascular Dysfunction after Spinal Cord Injury

(2008) Richard L Benton et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

(2008) Davide Lecca et al.   PLoS One