JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

(2021) Shamik Mascharak et al.   SCIENCE

Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36

(2021) Ingrid Lua et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A

(2020) Kazumi Shimamoto et al.   CARCINOGENESIS

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

(2020) Lu Cui et al.   Nature Communications

Elucidating the fundamental fibrotic processes driving abdominal adhesion formation

(2020) Deshka S. Foster et al.   Nature Communications

Characterization of Diabetic and Non-Diabetic Foot Ulcers Using Single-Cell RNA-Sequencing

(2020) Michael Januszyk et al.   Micromachines

CD47 prevents the elimination of diseased fibroblasts in scleroderma

(2020) Tristan Lerbs et al.   JCI Insight

Salvianolic Acids: Potential Source of Natural Drugs for the Treatment of Fibrosis Disease and Cancer

(2019) Lunkun Ma et al.   Frontiers in Pharmacology

Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells

(2019) Evan J. Morrison et al.   Nutrients

Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK

(2019) Jiaqi Liu et al.   CELL AND TISSUE RESEARCH

c-Jun overexpression in CAR T cells induces exhaustion resistance

(2019) Rachel C. Lynn et al.   NATURE

Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts

(2018) Yanni Wang et al.   EXPERIMENTAL CELL RESEARCH

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts

(2018) Jan-Niklas Schulz et al.   MATRIX BIOLOGY

Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets

(2018) Jacqueline Larouche et al.   Advances in Wound Care

Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease

(2018) Shruti Naik et al.   CELL

Increased expression of latent TGF-β-binding protein 4 affects the fibrotic process in scleroderma by TGF-β/SMAD signaling

(2017) Jiaying Lu et al.   LABORATORY INVESTIGATION

Unifying mechanism for different fibrotic diseases

(2017) Gerlinde Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AP-1 Is a Key Regulator of Proinflammatory Cytokine TNFα-mediated Triple-negative Breast Cancer Progression

(2016) Yichun Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

irCLIP platform for efficient characterization of protein–RNA interactions

(2016) Brian J Zarnegar et al.   NATURE METHODS

Salvianolic Acid B Attenuates Experimental Pulmonary Fibrosis through Inhibition of the TGF-β Signaling Pathway

(2016) Qingmei Liu et al.   Scientific Reports

Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation

(2015) Fujun Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Soy Isoflavone Glycitin (4'-Hydroxy-6-Methoxyisoflavone-7-D-Glucoside) Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β Signaling

(2015) Young Mee Kim et al.   PHYTOTHERAPY RESEARCH

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration

(2015) Guodong Li et al.   Acta Pharmaceutica Sinica B

Salvianolic Acid B Inhibited PPARγ Expression and Attenuated Weight Gain in Mice with High-Fat Diet-Induced Obesity

(2014) Peijian Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

(2014) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Tracking the Elusive Fibrocyte: Identification and Characterization of Collagen-Producing Hematopoietic Lineage Cells During Murine Wound Healing

(2014) Hirotaka Suga et al.   STEM CELLS

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner

(2012) Yi Bao et al.   ATHEROSCLEROSIS

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis

(2011) Jérôme Avouac et al.   ARTHRITIS AND RHEUMATISM

Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro

(2010) Qing-Lan Wang et al.   BMC CELL BIOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Scarless Fetal Wound Healing: A Basic Science Review

(2010) Barrett J. Larson et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

(2009) R. R. Driskell et al.   DEVELOPMENT

CD36 Regulates Oxidative Stress and Inflammation in Hypercholesterolemic CKD

(2009) D. M. Okamura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nuclear Factor I-C Links Platelet-Derived Growth Factor and Transforming Growth Factor  1 Signaling to Skin Wound Healing Progression

(2009) G. Plasari et al.   MOLECULAR AND CELLULAR BIOLOGY

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Scar Treatments: Preclinical and Clinical Studies

(2008) Richard G. Reish et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH