Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury

Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

(2015) Sonja Rittchen et al.   BIOMATERIALS

Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination

(2015) Yongjie Zhang et al.   EXPERIMENTAL NEUROLOGY

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

(2015) Scott M. Dyck et al.   EXPERIMENTAL NEUROLOGY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury

(2015) Yonggang Li et al.   Journal of Neuroinflammation

Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination

(2015) A. Doring et al.   JOURNAL OF NEUROSCIENCE

SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease

(2015) Ernest S. Smith et al.   NEUROBIOLOGY OF DISEASE

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway

(2015) Scott M. Dyck et al.   STEM CELLS

Myelin damage and repair in pathologic CNS: challenges and prospects

(2015) Arsalan Alizadeh et al.   Frontiers in Molecular Neuroscience

Oligodendrocyte Birth and Death following Traumatic Brain Injury in Adult Mice

(2015) Krista A. Dent et al.   PLoS One

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Long-Term Maintenance of Na+ Channels at Nodes of Ranvier Depends on Glial Contact Mediated by Gliomedin and NrCAM

(2014) V. Amor et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Remyelination after spinal cord injury: Is it a target for repair?

(2014) Jason R. Plemel et al.   PROGRESS IN NEUROBIOLOGY

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Dysregulation of the neuregulin-1-ErbB network modulates endogenous oligodendrocyte differentiation and preservation after spinal cord injury

(2013) Marie-Krystel Gauthier et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ

(2013) James C. Pendleton et al.   EXPERIMENTAL NEUROLOGY

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

(2013) Jason R. Plemel et al.   GLIA

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain

(2013) Victoria A. Rafalski et al.   NATURE CELL BIOLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Neural progenitor cell apoptosis and differentiation were affected by activated microglia in spinal cord slice culture

(2013) Xuqing Liu et al.   NEUROLOGICAL SCIENCES

Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice

(2013) H. Sabelstrom et al.   SCIENCE

Differential regulation of proliferation and neuronal differentiation in adult rat spinal cord neural stem/progenitors by ERK1/2, Akt, and PLCγ

(2013) Wai Si Chan et al.   Frontiers in Molecular Neuroscience

Proposed evolutionary changes in the role of myelin

(2013) Klaus M. Stiefel et al.   Frontiers in Neuroscience

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development

(2012) M. Cristina Ortega et al.   EXPERIMENTAL NEUROLOGY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Axonal Thinning and Extensive Remyelination without Chronic Demyelination in Spinal Injured Rats

(2012) B. E. Powers et al.   JOURNAL OF NEUROSCIENCE

ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination

(2012) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

(2012) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

(2012) Zaal Kokaia et al.   NATURE NEUROSCIENCE

Remyelination Therapy for Multiple Sclerosis

(2012) Michael B. Keough et al.   Neurotherapeutics

Chondroitinase and Growth Factors Enhance Activation and Oligodendrocyte Differentiation of Endogenous Neural Precursor Cells after Spinal Cord Injury

(2012) Soheila Karimi-Abdolrezaee et al.   PLoS One

Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain

(2012) Feng Tao et al.   STEM CELLS

Communication between pathogenic T cells and myeloid cells in neuroinflammatory disease

(2012) Laura Codarri et al.   TRENDS IN IMMUNOLOGY

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6

(2011) Wenda Gao et al.   CELL CYCLE

Neuregulin-1β Prevents Ca2+ Overloading and Apoptosis Through PI3K/Akt Activation in Cultured Dorsal Root Ganglion Neurons with Excitotoxicity Induced by Glutamate

(2011) Zhen Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

GGF2 (Nrg1-β3) treatment enhances NG2+ cell response and improves functional recovery after spinal cord injury

(2011) Matthew T. Whittaker et al.   GLIA

Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Brain Ischemia through Akt Signal Transduction

(2011) Derrick D. Rowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

(2011) Justin R. Siebert et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

(2011) Y. A. Syed et al.   JOURNAL OF NEUROSCIENCE

Axonally Derived Neuregulin-1 Is Required for Remyelination and Regeneration after Nerve Injury in Adulthood

(2011) F. R. Fricker et al.   JOURNAL OF NEUROSCIENCE

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

(2011) H. B. F. Pohl et al.   JOURNAL OF NEUROSCIENCE

Astrocytes from the Contused Spinal Cord Inhibit Oligodendrocyte Differentiation of Adult Oligodendrocyte Precursor Cells by Increasing the Expression of Bone Morphogenetic Proteins

(2011) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing of Oligodendrocyte Differentiation

(2011) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier

(2011) N. Ohno et al.   JOURNAL OF NEUROSCIENCE

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrocytes Inhibit the Survival and Differentiation of Oligodendrocyte Precursor Cells by Secreted TNF-α

(2011) Zhida Su et al.   JOURNAL OF NEUROTRAUMA

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Brain-Derived Neurotrophic Factor Promotes Central Nervous System Myelination via a Direct Effect upon Oligodendrocytes

(2011) Junhua Xiao et al.   NEUROSIGNALS

Oligodendrocyte Fate after Spinal Cord Injury

(2011) Akshata Almad et al.   Neurotherapeutics

A Recombinant Human Neuregulin-1 Peptide Improves Preservation of the Rodent Heart After Prolonged Hypothermic Storage

(2011) Andrew Jabbour et al.   TRANSPLANTATION

Neuregulin-1 regulates the expression of Akt, Bcl-2, and Bad signaling after focal cerebral ischemia in ratsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

(2010) Wen-Ping Guo et al.   Biochemistry and Cell Biology

Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury

(2010) Elizabeth J. Bradbury et al.   BRAIN RESEARCH BULLETIN

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

(2010) Fanie Barnabé-Heider et al.   Cell Stem Cell

Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination

(2010) N. Syed et al.   JOURNAL OF NEUROSCIENCE

Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord

(2010) S. Karimi-Abdolrezaee et al.   JOURNAL OF NEUROSCIENCE

Inflammation in Neurological Disorders: A Help or a Hindrance?

(2010) V. Wee Yong   NEUROSCIENTIST

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Toxic effect of blood components on perinatal rat subventricular zone cells and oligodendrocyte precursor cell proliferation, differentiation and migration in culture

(2009) Packiasamy A. R. Juliet et al.   JOURNAL OF NEUROCHEMISTRY

Endothelin-1 Regulates Oligodendrocyte Development

(2009) A. Gadea et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Neuregulin-1 modulates the differentiation of neural stem cells in vitro trough an interaction with the Swi/Snf complex

(2009) D. Pirotte et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Upregulation of chemokine receptor expression by IL-10/IL-4 in adult neural stem cells

(2008) Yangtai Guan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Endothelin-1 Regulates Astrocyte Proliferation and Reactive Gliosis via a JNK/c-Jun Signaling Pathway

(2008) A. Gadea et al.   JOURNAL OF NEUROSCIENCE

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway

(2008) Ashlee Van't Veer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death

(2008) Haruo Kanno et al.   NEUROBIOLOGY OF DISEASE

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

(2008) Bastian G. Brinkmann et al.   NEURON

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

(2008) Asya Rolls et al.   PLOS MEDICINE

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Platelet-derived growth factor-AA mediates oligodendrocyte lineage differentiation through activation of extracellular signal-regulated kinase signaling pathway

(2007) J.-G. Hu et al.   NEUROSCIENCE