Spinal cord repair: advances in biology and technology

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

(2019) Thomas H. Hutson et al.   Science Translational Medicine

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations

(2018) Bo Chen et al.   CELL

An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury

(2018) Aaron A. Phillips et al.   JOURNAL OF NEUROTRAUMA

Dissecting spinal cord regeneration

(2018) Michael V. Sofroniew   NATURE

Restorative effects of human neural stem cell grafts on the primate spinal cord

(2018) Ephron S Rosenzweig et al.   NATURE MEDICINE

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

(2018) Leonie Asboth et al.   NATURE NEUROSCIENCE

Connecting neuronal circuits for movement

(2018) Silvia Arber et al.   SCIENCE

Rehabilitative Training in Animal Models of Spinal Cord Injury

(2018) Abel Torres-Espín et al.   JOURNAL OF NEUROTRAUMA

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

(2018) Megan L. Gill et al.   NATURE MEDICINE

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

(2018) Marco Bonizzato et al.   Nature Communications

Targeted neurotechnology restores walking in humans with spinal cord injury

(2018) Fabien B. Wagner et al.   NATURE

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

(2018) Emanuele Formento et al.   NATURE NEUROSCIENCE

Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats

(2017) Kinon Chen et al.   EXPERIMENTAL NEUROLOGY

Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury

(2017) N. Zareen et al.   EXPERIMENTAL NEUROLOGY

Cell biology of spinal cord injury and repair

(2017) Timothy M. O’Shea et al.   JOURNAL OF CLINICAL INVESTIGATION

Reticulospinal Contributions to Gross Hand Function after Human Spinal Cord Injury

(2017) Stuart N. Baker et al.   JOURNAL OF NEUROSCIENCE

Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure

(2017) Marie-Pascale Côté et al.   JOURNAL OF NEUROTRAUMA

Repetitive Intermittent Hypoxia and Locomotor Training Enhances Walking Function in Incomplete Spinal Cord Injury Subjects: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

(2017) Angela Navarrete-Opazo et al.   JOURNAL OF NEUROTRAUMA

Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury

(2017) Kim D. Anderson et al.   JOURNAL OF NEUROTRAUMA

Paired motor cortex and cervical epidural electrical stimulation timed to converge in the spinal cord promotes lasting increases in motor responses

(2017) Asht M. Mishra et al.   JOURNAL OF PHYSIOLOGY-LONDON

Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration

(2017) A Bolu Ajiboye et al.   LANCET

Electrical Neuromodulation of the Respiratory System After Spinal Cord Injury

(2017) Jan T. Hachmann et al.   MAYO CLINIC PROCEEDINGS

Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

(2017) Peter J. Grahn et al.   MAYO CLINIC PROCEEDINGS

Cell transplantation therapy for spinal cord injury

(2017) Peggy Assinck et al.   NATURE NEUROSCIENCE

Ca2+ activity signatures of myelin sheath formation and growth in vivo

(2017) Marion Baraban et al.   NATURE NEUROSCIENCE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic

(2017) Enrico Rejc et al.   Scientific Reports

Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration

(2016) Carla C. Winter et al.   Acta Biomaterialia

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Intraspinal microstimulation produces over-ground walking in anesthetized cats

(2016) B J Holinski et al.   Journal of Neural Engineering

Proteoglycans and axon guidance: a new relationship between old partners

(2016) Masayuki Masu   JOURNAL OF NEUROCHEMISTRY

Paired associative transspinal and transcortical stimulation produces plasticity in human cortical and spinal neuronal circuits

(2016) Luke Dixon et al.   JOURNAL OF NEUROPHYSIOLOGY

Re-Establishment of Cortical Motor Output Maps and Spontaneous Functional Recovery via Spared Dorsolaterally Projecting Corticospinal Neurons after Dorsal Column Spinal Cord Injury in Adult Mice

(2016) B. J. Hilton et al.   JOURNAL OF NEUROSCIENCE

Competition with Primary Sensory Afferents Drives Remodeling of Corticospinal Axons in Mature Spinal Motor Circuits

(2016) Y.-Q. Jiang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

(2016) Marco Capogrosso et al.   NATURE

Restoring cortical control of functional movement in a human with quadriplegia

(2016) Chad E. Bouton et al.   NATURE

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

(2016) Ken Kadoya et al.   NATURE MEDICINE

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

(2016) Nikolaus Wenger et al.   NATURE MEDICINE

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

(2016) Edmund R Hollis et al.   NATURE NEUROSCIENCE

Inside Out: Core Network of Transcription Factors Drives Axon Regeneration

(2016) Choya Yoon et al.   NEURON

Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury

(2016) Eduardo Martin Moraud et al.   NEURON

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

Long-Distance Descending Spinal Neurons Ensure Quadrupedal Locomotor Stability

(2016) Ludwig Ruder et al.   NEURON

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Targeting Lumbar Spinal Neural Circuitry by Epidural Stimulation to Restore Motor Function After Spinal Cord Injury

(2016) Karen Minassian et al.   Neurotherapeutics

Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish

(2016) M. H. Mokalled et al.   SCIENCE

Intracortical microstimulation of human somatosensory cortex

(2016) S. N. Flesher et al.   Science Translational Medicine

Materials and technologies for soft implantable neuroprostheses

(2016) Stéphanie P. Lacour et al.   Nature Reviews Materials

Long-Term Training with a Brain-Machine Interface-Based Gait Protocol Induces Partial Neurological Recovery in Paraplegic Patients

(2016) Ana R. C. Donati et al.   Scientific Reports

Effects of Repetitive Transcranial Magnetic Stimulation on Recovery of Function After Spinal Cord Injury

(2015) Toshiki Tazoe et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Design and Synthesis of Nonionic Copolypeptide Hydrogels with Reversible Thermoresponsive and Tunable Physical Properties

(2015) Shanshan Zhang et al.   BIOMACROMOLECULES

Human spinal locomotor control is based on flexibly organized burst generators

(2015) Simon M. Danner et al.   BRAIN

Permissive Schwann Cell Graft/Spinal Cord Interfaces for Axon Regeneration

(2015) Ryan R. Williams et al.   CELL TRANSPLANTATION

Noninvasive Reactivation of Motor Descending Control after Paralysis

(2015) Yury P. Gerasimenko et al.   JOURNAL OF NEUROTRAUMA

Clinical translation of a high-performance neural prosthesis

(2015) Vikash Gilja et al.   NATURE MEDICINE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury

(2015) Y. Zhu et al.   NEUROBIOLOGY OF DISEASE

Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury

(2015) Víctor M. López-Álvarez et al.   PAIN

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration

(2015) Katherine T. Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted, activity-dependent spinal stimulation produces long-lasting motor recovery in chronic cervical spinal cord injury

(2015) Jacob G. McPherson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electronic dura mater for long-term multimodal neural interfaces

(2015) I. R. Minev et al.   SCIENCE

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

(2015) Lucia Friedli et al.   Science Translational Medicine

Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface

(2015) Beata Jarosiewicz et al.   Science Translational Medicine

Reply: No dawn yet of a new age in spinal cord rehabilitation

(2015) Claudia Angeli et al.   BRAIN

The role of neuronal versus astrocyte-derived heparan sulfate proteoglycans in brain development and injury: Table 1

(2014) Isabella Farhy Tselnicker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans

(2014) Claudia A. Angeli et al.   BRAIN

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

(2014) Aya Takeoka et al.   CELL

Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin

(2014) Chiara Pivetta et al.   CELL

Nogo limits neural plasticity and recovery from injury

(2014) Martin E Schwab et al.   CURRENT OPINION IN NEUROBIOLOGY

Axon guidance and injury—lessons from Wnts and Wnt signaling

(2014) Keisuke Onishi et al.   CURRENT OPINION IN NEUROBIOLOGY

Contrasting the Glial Response to Axon Injury in the Central and Peripheral Nervous Systems

(2014) Amanda Brosius Lutz et al.   DEVELOPMENTAL CELL

Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system

(2014) Irja Elliott Donaghue et al.   JOURNAL OF CONTROLLED RELEASE

Astroglial-Derived Periostin Promotes Axonal Regeneration after Spinal Cord Injury

(2014) C.-H. Shih et al.   JOURNAL OF NEUROSCIENCE

Identification of a cellular node for motor control pathways

(2014) Ariel J Levine et al.   NATURE NEUROSCIENCE

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

(2014) N. Wenger et al.   Science Translational Medicine

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration

(2014) Tyson J. Edwards et al.   Cell Reports

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

(2013) Janine Beauparlant et al.   BRAIN

Therapeutic intraspinal microstimulation improves forelimb function after cervical contusion injury

(2013) M R Kasten et al.   Journal of Neural Engineering

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

(2013) K. Zukor et al.   JOURNAL OF NEUROSCIENCE

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

(2013) M. Capogrosso et al.   JOURNAL OF NEUROSCIENCE

MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study

(2013) Patrick Freund et al.   LANCET NEUROLOGY

Spike-Timing-Dependent Plasticity in Primate Corticospinal Connections Induced during Free Behavior

(2013) Yukio Nishimura et al.   NEURON

Plasticity in the Injured Brain

(2013) Justine J. Overman et al.   NEUROSCIENTIST

Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats

(2013) L. C. Bachmann et al.   Science Translational Medicine

Personalized Neuroprosthetics

(2013) D. Borton et al.   Science Translational Medicine

Where no synapses go: gatekeepers of circuit remodeling and synaptic strength

(2013) Yevgeniya A. Mironova et al.   TRENDS IN NEUROSCIENCES

Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury

(2013) Yukio Nishimura et al.   Frontiers in Neural Circuits

Long-Term Viral Brain-Derived Neurotrophic Factor Delivery Promotes Spasticity in Rats with a Cervical Spinal Cord Hemisection

(2013) Karim Fouad et al.   Frontiers in Neurology

Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection

(2012) Mingyong Gao et al.   BIOMATERIALS

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

(2012) Paul Lu et al.   CELL

The perineuronal net and the control of CNS plasticity

(2012) Difei Wang et al.   CELL AND TISSUE RESEARCH

Repetitive Intermittent Hypoxia Induces Respiratory and Somatic Motor Recovery after Chronic Cervical Spinal Injury

(2012) M. R. Lovett-Barr et al.   JOURNAL OF NEUROSCIENCE

Corticospinal reorganization after spinal cord injury

(2012) Martin Oudega et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-performance neuroprosthetic control by an individual with tetraplegia

(2012) Jennifer L Collinger et al.   LANCET

Restoration of grasp following paralysis through brain-controlled stimulation of muscles

(2012) C. Ethier et al.   NATURE

Genetic dissection of the circuit for hand dexterity in primates

(2012) Masaharu Kinoshita et al.   NATURE

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

(2012) Nicola J. Allen et al.   NATURE

Reach and grasp by people with tetraplegia using a neurally controlled robotic arm

(2012) Leigh R. Hochberg et al.   NATURE

Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

(2012) Nadia Dominici et al.   NATURE MEDICINE

Concepts and Methods for the Study of Axonal Regeneration in the CNS

(2012) Mark H. Tuszynski et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors

(2012) S. de Lima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

(2012) R. van den Brand et al.   SCIENCE

Reanimating the arm and hand with intraspinal microstimulation

(2011) Jonas B Zimmermann et al.   Journal of Neural Engineering

Grafted Neural Progenitors Integrate and Restore Synaptic Connectivity across the Injured Spinal Cord

(2011) J. F. Bonner et al.   JOURNAL OF NEUROSCIENCE

Motor antagonism exposed by spatial segregation and timing of neurogenesis

(2011) Marco Tripodi et al.   NATURE

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Lamina-specific restoration of serotonergic projections after Nogo-A antibody treatment of spinal cord injury in rats

(2010) Angela Müllner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury

(2010) Masahiko Abematsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors

(2010) Katherine C Murray et al.   NATURE MEDICINE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury

(2010) Ephron S Rosenzweig et al.   NATURE NEUROSCIENCE

Behavior of spinal neurons deprived of supraspinal input

(2010) Volker Dietz   Nature Reviews Neurology

Cellular Strategies of Axonal Pathfinding

(2010) J. Raper et al.   Cold Spring Harbor Perspectives in Biology

Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury

(2009) Irin C. Maier et al.   BRAIN

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

(2009) Guillermo García-Alías et al.   NATURE NEUROSCIENCE

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

(2009) Grégoire Courtine et al.   NATURE NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions

(2008) K. P. Horn et al.   JOURNAL OF NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro

(2008) Stefan Plantman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Direct control of paralysed muscles by cortical neurons

(2008) Chet T. Moritz et al.   NATURE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Plasticity of interneuronal networks of the functionally isolated human spinal cord

(2007) Susan J. Harkema   BRAIN RESEARCH REVIEWS

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

(2007) Gregoire Courtine et al.   NATURE MEDICINE