Exploring the Role of CLU in the Pathogenesis of Alzheimer’s Disease

Biological signatures of Alzheimer Disease

(2020) Poornima Sharma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease

(2020) Md. Sahab Uddin et al.   CURRENT PHARMACEUTICAL DESIGN

Neuron‐Glia interaction: Molecular basis of Alzheimer’s Disease and Applications of Neuroproteomics

(2020) Abdallah Mohammad Ibrahim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease

(2020) Md. Sahab Uddin et al.   IUBMB LIFE

TV 3326 for Alzheimer’s dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer’s‐like neuropathology

(2020) Md. Sahab Uddin et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   NEUROTOXICITY RESEARCH

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   Oxidative Medicine and Cellular Longevity

Exploring the Potential of Neuroproteomics in Alzheimer's Disease

(2020) Md. Sahab Uddin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   NEUROTOXICITY RESEARCH

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease

(2020) Md. Sahab Uddin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease

(2019) Md. Sahab Uddin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells

(2018) Martina Zandl-Lang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

(2018) Liv Tybjærg Nordestgaard et al.   BMC Medicine

Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's Disease

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

(2018) Jacqueline P. Robbins et al.   Frontiers in Neuroscience

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

Metallo-pathways to Alzheimer's disease: lessons from genetic disorders of copper trafficking

(2016) M. A. Greenough et al.   Metallomics

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses

(2016) P Cunin et al.   Cell Death & Disease

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microgliain vitro

(2014) Sandra D. Mulder et al.   GLIA

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains

(2013) Roberta Cascella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid  -Mediated Synaptic Loss

(2012) S. A. Purro et al.   JOURNAL OF NEUROSCIENCE

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy

(2012) Jin-Tai Yu et al.   MOLECULAR NEUROBIOLOGY

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

(2012) R Killick et al.   MOLECULAR PSYCHIATRY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease

(2012) Rosanna Squitti et al.   REJUVENATION RESEARCH

Plasma Clusterin and the Risk of Alzheimer Disease

(2011) Elisabeth M. C. Schrijvers   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clusterin (Apolipoprotein J), a Molecular Chaperone That Facilitates Degradation of the Copper-ATPases ATP7A and ATP7B

(2011) Stephanie Materia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

(2010) David A Elliott et al.   Clinical Lipidology

Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins

(2010) Henrietta M. Nielsen et al.   GLIA

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Clusterin: A forgotten player in Alzheimer's disease

(2009) Tapio Nuutinen et al.   BRAIN RESEARCH REVIEWS

Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake

(2009) Justin J. Yerbury et al.   CELL STRESS & CHAPERONES

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

Identification of Clusterin Domain Involved in NF-κB Pathway Regulation

(2009) Abdellatif Essabbani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

(2009) Nicholas H. Varvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Structural and Quantitative Comparison of Cerebrospinal Fluid Glycoproteins in Alzheimer’s Disease Patients and Healthy Individuals

(2008) Carina Sihlbom et al.   NEUROCHEMICAL RESEARCH

Clusterin, a novel modulator of TGF-β signaling, is involved in Smad2/3 stability

(2007) Kwan-Bok Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of NF-κB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis

(2007) O. Takase et al.   KIDNEY INTERNATIONAL