Protein lactylation induced by neural excitation

Lung Myofibroblast Promote Macrophage Pro-fibrotic Activity Through Lactate-induced Histone Lactylation

(2020) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Histone H1 Post-Translational Modifications: Update and Future Perspectives

(2020) Marta Andrés et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence for altered energy metabolism, increased lactate, and decreased pH in schizophrenia brain: A focused review and meta-analysis of human postmortem and magnetic resonance spectroscopy studies

(2020) Brandon S. Pruett et al.   SCHIZOPHRENIA RESEARCH

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

(2020) Ricardo A. Irizarry-Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin

(2019) Minami Tanaka et al.   GENES TO CELLS

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases

(2019) Nabil Karnib et al.   NEUROPSYCHOPHARMACOLOGY

Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production

(2019) Jean Pierre Oses et al.   EPILEPSY RESEARCH

Chronic Ethanol Exposure Disrupts Lactate and Glucose Homeostasis and Induces Dysfunction of the Astrocyte–Neuron Lactate Shuttle in the Brain

(2019) Daniel Lindberg et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Increased depression-related behavior during the postpartum period in inbred BALB/c and C57BL/6 strains

(2019) Hirotaka Shoji et al.   Molecular Brain

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies

(2018) Asli Ercan Dogan et al.   NEUROPSYCHOPHARMACOLOGY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

(2017) Hideo Hagihara et al.   NEUROPSYCHOPHARMACOLOGY

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment

(2017) Yuki Imoto et al.   Molecular Brain

Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder

(2016) J Ernst et al.   MOLECULAR PSYCHIATRY

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

(2016) Bangkun Yang et al.   PSYCHOPHARMACOLOGY

Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model

(2016) Hideo Hagihara et al.   Cell Reports

Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders

(2016) Ignacio Negrón-Oyarzo et al.   NEURAL PLASTICITY

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

(2016) Min Ma et al.   Scientific Reports

Mitochondrial pyruvate import and its effects on homeostasis

(2015) Benoît Vanderperre et al.   CURRENT OPINION IN CELL BIOLOGY

Neurometabolic coupling between neural activity, glucose, and lactate in activated visual cortex

(2015) Baowang Li et al.   JOURNAL OF NEUROCHEMISTRY

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Subchronic and mild social defeat stress accelerates food intake and body weight gain with polydipsia-like features in mice

(2014) Tatsuhiko Goto et al.   BEHAVIOURAL BRAIN RESEARCH

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

(2014) João M.N. Duarte et al.   NEUROBIOLOGY OF AGING

Fueling and Imaging Brain Activation

(2012) Gerald A Dienel   ASN Neuro

A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation

(2012) K. Kamieniarz et al.   GENES & DEVELOPMENT

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The Use of Animal Models in Psychiatric Research and Treatment

(2008) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH