Is L-Lactate a Novel Signaling Molecule in the Brain?

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

(2016) Bjørn Quistorff et al.   Aging-US

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

Small is fast: astrocytic glucose and lactate metabolism at cellular resolution

(2013) L. F. Barros et al.   Frontiers in Cellular Neuroscience

Fueling and Imaging Brain Activation

(2012) Gerald A Dienel   ASN Neuro

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels

(2011) Anne Venner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain glycogen supercompensation following exhaustive exercise

(2011) Takashi Matsui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio

(2011) B. Quistorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogenolysis in Astrocytes Supports Blood-Borne Glucose Channeling Not Glycogen-Derived Lactate Shuttling to Neurons: Evidence from Mathematical Modeling

(2010) Mauro DiNuzzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal

(2010) M. P. Parsons et al.   JOURNAL OF NEUROSCIENCE

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

(2010) F. Boumezbeur et al.   JOURNAL OF NEUROSCIENCE

Increased plasma d-lactic acid associated with impaired memory in rats

(2010) T.L. Hanstock et al.   PHYSIOLOGY & BEHAVIOR

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Brain Glycogen Metabolism During and After Hypoglycemia

(2009) G. Oz et al.   DIABETES

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

(2009) Gautam K. Gandhi et al.   JOURNAL OF NEUROCHEMISTRY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of astrocytic energy metabolism by d-lactate exposure impairs memory

(2007) Marie E. Gibbs et al.   NEUROCHEMISTRY INTERNATIONAL