The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

(2015) Giorgio Santoni et al.   Journal of Neuroinflammation

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Lactate: Brain Fuel in Human Traumatic Brain Injury: A Comparison with Normal Healthy Control Subjects

(2015) Thomas C. Glenn et al.   JOURNAL OF NEUROTRAUMA

Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway

(2014) Ahmad Farooq et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing

(2014) Taku Sakurai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions

(2014) S. Lucken-Ardjomande Hasler et al.   JOURNAL OF CELL SCIENCE

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate Shuttling and Lactate use as Fuel after Traumatic Brain Injury: Metabolic Considerations

(2014) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemic tolerance in an in vivo model of glutamate preconditioning

(2014) Yomna Badawi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contributions of glycogen to astrocytic energetics during brain activation

(2014) Gerald A. Dienel et al.   METABOLIC BRAIN DISEASE

Intratumoral heterogeneity and intraclonal plasticity: from warburg to oxygen and back again

(2014) C. A. Conrad et al.   NEURO-ONCOLOGY

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors

(2013) Stefan Offermanns   Annual Review of Pharmacology and Toxicology

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

A large-scale neural network model of the influence of neuromodulatory levels on working memory and behavior

(2013) Michael C. Avery et al.   Frontiers in Computational Neuroscience

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Ischemic preconditioning and clinical scenarios

(2012) Srinivasan V. Narayanan et al.   CURRENT OPINION IN NEUROLOGY

Oxygen Consumption and Blood Flow Coupling in Human Motor Cortex during Intense Finger Tapping: Implication for a Role of Lactate

(2012) Manouchehr S Vafaee et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Beta2-Adrenergic Receptor and Astrocyte Glucose Metabolism

(2012) Jun-hong Dong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance

(2012) John O’Donnell et al.   NEUROCHEMICAL RESEARCH

Extracellular Levels of Lactate, but Not Oxygen, Reflect Sleep Homeostasis in the Rat Cerebral Cortex

(2012) Michael B. Dash et al.   SLEEP

Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

(2012) Curt A. Dvorak et al.   ACS Medicinal Chemistry Letters

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Prefrontal Cortical Organization and Function: Implications for Externalizing Disorders

(2011) Amy F.T. Arnsten et al.   BIOLOGICAL PSYCHIATRY

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia

(2011) Amy F.T. Arnsten   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

(2011) S. Offermanns et al.   PHARMACOLOGICAL REVIEWS

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

The ketogenic diet changes metabolite levels in hippocampal extracellular fluid

(2010) Ramakrishna Samala et al.   NEUROCHEMISTRY INTERNATIONAL

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cancer-Related Fatigue: Central or Peripheral?

(2009) Tugba Yavuzsen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

The discovery of central monoamine neurons gave volume transmission to the wired brain

(2009) Kjell Fuxe et al.   PROGRESS IN NEUROBIOLOGY

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of signaling and functional activities of an orphan GPCR, GPR81

(2008) Hongfei Ge et al.   JOURNAL OF LIPID RESEARCH

Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellumin vivo

(2008) Kirsten Caesar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE