Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System

The Molecular Mechanisms of Excessive Hippocampal Endoplasmic Reticulum Stress Depressing Cognition-related Proteins Expression and the Regulatory Effects of Nrf2

(2020) Ming Cai et al.   NEUROSCIENCE

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

The lactate receptor HCAR1 modulates neuronal network activity through the activation of Gα and Gβɣ subunits

(2019) Haíssa de Castro Abrantes et al.   JOURNAL OF NEUROSCIENCE

Exercise as a prescription for patients with various diseases

(2019) Xin Luan et al.   Journal of Sport and Health Science

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating mitochondrial dynamics

(2019) Baixia Li et al.   BEHAVIOURAL BRAIN RESEARCH

mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

(2019) Yaling Hu et al.   GLIA

Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling

(2019) Claire J. Scavuzzo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Mitochondrial quality control pathways: PINK1 acts as a gatekeeper

(2018) Elvira P. Leites et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial cAMP-PKA signaling: What do we really know?

(2018) Yasmine Ould Amer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes

(2018) Ciarán E. Fealy et al.   EXPERIMENTAL PHYSIOLOGY

Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men

(2018) Takeshi Hashimoto et al.   FASEB JOURNAL

Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1

(2018) Gabriel Herrera-López et al.   HIPPOCAMPUS

The inhibitory effect of LPS on the expression of GPR81 lactate receptor in blood-brain barrier model in vitro

(2018) Elizaveta B. Boitsova et al.   Journal of Neuroinflammation

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Impact of high intensity interval exercise on executive function and brain derived neurotrophic factor in healthy college aged males

(2018) Aaron L. Slusher et al.   PHYSIOLOGY & BEHAVIOR

High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats

(2018) Daniel A. Freitas et al.   PHYSIOLOGY & BEHAVIOR

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

(2018) Nina Vardjan et al.   Frontiers in Molecular Neuroscience

Perceptual and prefrontal cortex haemodynamic responses to high-intensity interval exercise with decreasing and increasing work-intensity in adolescents

(2018) Adam A. Malik et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

High-Intensity Interval Training Is Associated With Alterations in Blood Biomarkers Related to Brain Injury

(2018) Alex P. Di Battista et al.   Frontiers in Physiology

Acute high-intensity interval exercise induces greater levels of serum brain-derived neurotrophic factor in obese individuals

(2018) Alexandra L Rodriguez et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Exercise intensity affects acute neurotrophic and neurophysiologic responses post-stroke

(2018) Pierce Boyne et al.   JOURNAL OF APPLIED PHYSIOLOGY

L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis

(2018) Michael B. Margineanu et al.   Frontiers in Molecular Neuroscience

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dynamics in neuronal injury, development and plasticity

(2017) Kyle H. Flippo et al.   JOURNAL OF CELL SCIENCE

Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults

(2017) Matthew M Robinson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels

(2017) James P. Coxon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lysosomal Proteolysis Is Associated With Exercise-Induced Improvement of Mitochondrial Quality Control in Aged Hippocampus

(2017) Li Luo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

The feasibility of an acute high-intensity exercise bout to promote locomotor learning after stroke

(2017) Charalambos C. Charalambous et al.   Topics in Stroke Rehabilitation

‘SNO’-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders

(2017) Tomohiro Nakamura et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Functional High-Intensity Circuit Training Improves Body Composition, Peak Oxygen Uptake, Strength, and Alters Certain Dimensions of Quality of Life in Overweight Women

(2017) Billy Sperlich et al.   Frontiers in Physiology

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

(2017) Susana Rovira-Llopis et al.   Redox Biology

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease

(2016) T.C. Bernardo et al.   BRAIN PATHOLOGY

Mitochondrial cAMP signaling

(2016) Fan Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained

(2016) Miriam S. Nokia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males

(2016) Hayato Tsukamoto et al.   PHYSIOLOGY & BEHAVIOR

Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise

(2016) Hayato Tsukamoto et al.   PHYSIOLOGY & BEHAVIOR

Alterations in Mitochondrial Quality Control in Alzheimer’s Disease

(2016) Qian Cai et al.   Frontiers in Cellular Neuroscience

The critical roles of mitophagy in cerebral ischemia

(2016) Yan-Cheng Tang et al.   Protein & Cell

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

Glycolysis-mediated control of blood-brain barrier development and function

(2015) Alla B. Salmina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

BDNF, IGF-I, Glucose and Insulin during Continuous and Interval Exercise in Type 1 Diabetes

(2015) C. Tonoli et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Is L-Lactate a Novel Signaling Molecule in the Brain?

(2015) Valentina Mosienko et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain

(2015) Mohammad Esmaiel Afzalpour et al.   PHYSIOLOGY & BEHAVIOR

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lactate Transport and Signaling in the Brain: Potential Therapeutic Targets and Roles in Body—Brain Interaction

(2014) Linda Hildegard Bergersen   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

(2014) Lezi E et al.   NEUROBIOLOGY OF AGING

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Low-Volume High-Intensity Interval Training (HIT) on Fitness in Adults: A Meta-Analysis of Controlled and Non-Controlled Trials

(2014) Matthew Weston et al.   SPORTS MEDICINE

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Lactate administration reproduces specific brain and liver exercise-related changes

(2013) Lezi E et al.   JOURNAL OF NEUROCHEMISTRY

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression

(2013) Deep Raj Sharma et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Physiological adaptations to low-volume, high-intensity interval training in health and disease

(2012) Martin J. Gibala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans

(2011) Peter Rasmussen et al.   FASEB JOURNAL

Mitochondrial Dynamics in Diabetes

(2010) Yisang Yoon et al.   ANTIOXIDANTS & REDOX SIGNALING

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Lactate infusion at rest increases BDNF blood concentration in humans

(2010) Thorsten Schiffer et al.   NEUROSCIENCE LETTERS

Mitochondrial biogenesis in exercise and in ageing☆

(2009) Jose Viña et al.   ADVANCED DRUG DELIVERY REVIEWS

Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease

(2009) Baiyang Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination

(2009) Wen Guo et al.   MITOCHONDRION

Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity

(2008) P. M. Haram et al.   CARDIOVASCULAR RESEARCH

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Brain foods: the effects of nutrients on brain function

(2008) Fernando Gómez-Pinilla   NATURE REVIEWS NEUROSCIENCE