Role of oxidative stress in the pathogenesis of COPD

Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment—From Mice to Men

(2022) Andreas von Knethen et al.   Biomedicines

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

(2021) Andrew W. Caliri et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

(2021) Goutam Mukherjee et al.   Communications Biology

Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway

(2021) Meng-Yu Zhang et al.   LIFE SCIENCES

Asthma-COPD overlap: current understanding and the utility of experimental models

(2021) Xiaofan Tu et al.   European Respiratory Review

Gasping for sulfide: A critical appraisal of hydrogen sulfide in lung disease and accelerated aging

(2021) Dario Pacitti et al.   ANTIOXIDANTS & REDOX SIGNALING

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

(2021) Sebastian T Lugg et al.   THORAX

The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication

(2021) Yulia Kargapolova et al.   Antioxidants

Effects of Inhaled Corticosteroid/long-acting beta-2 Agonist Combination on the Airway Microbiome of Patients with COPD: A Randomized Controlled Trial (DISARM)

(2021) Fernando Sergio Leitao Filho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammatory and oxidative biomarkers as determinants of functional capacity in patients with COPD assessed by 6-min walk test-derived outcomes

(2021) Camila D.C. Neves et al.   EXPERIMENTAL GERONTOLOGY

Enzymatic lysine oxidation as a posttranslational modification

(2021) Gemma Serra‐Bardenys et al.   FEBS Journal

Mitochondrial dysfunctions associated with chronic respiratory diseases and their targeted therapies: an update

(2021) Dinesh Kumar Chellappan et al.   Future Medicinal Chemistry

Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond

(2021) Samantha Minh Thy Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cigarette smoke-induced toxicity consequences of intracellular iron dysregulation and ferroptosis

(2021) Mohammad Reza Sepand et al.   LIFE SCIENCES

Corticosteroid resistance in asthma: Cellular and molecular mechanisms

(2021) Gaetano Caramori et al.   MOLECULAR ASPECTS OF MEDICINE

Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID-19—Mechanisms and Therapeutic Targets

(2021) Adriana Fodor et al.   Oxidative Medicine and Cellular Longevity

Therapeutic targets in lung tissue remodelling and fibrosis

(2021) Gang Liu et al.   PHARMACOLOGY & THERAPEUTICS

Diallyl disulfide prevents cigarette smoke-induced emphysema in mice

(2021) Aline de Oliveira Pontes Cardoso et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

(2021) David A. Skerrett‐Byrne et al.   RESPIROLOGY

Ferroptosis Meets Cell–Cell Contacts

(2021) Cornelia Dietrich et al.   Cells

A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

(2021) Richard Y. Kim et al.   Science Translational Medicine

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade

(2021) Davies Adeloye et al.   Journal of Global Health

Role of the mucins in pathogenesis of COPD: implications for therapy

(2020) Federica Lo Bello et al.   Expert Review of Respiratory Medicine

Knockout Mouse Models for Peroxiredoxins

(2020) Young Jae Lee   Antioxidants

Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis

(2020) Shuyun Wang et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Redox regulation by SOD2 modulates colorectal cancer tumorigenesis through AMPK‐mediated energy metabolism

(2020) Chen Zhou et al.   MOLECULAR CARCINOGENESIS

Emerging therapeutic targets and preclinical models for severe asthma

(2020) Izabela Galvão et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NOVEL antioxidant and oxidant biomarkers related to sarcopenia in COPD.

(2020) Walter Sepúlveda-Loyola et al.   HEART & LUNG

Oxidative stress-based therapeutics in COPD

(2020) Peter J. Barnes   Redox Biology

Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of Copd

(2020) Francesco Nucera et al.   CURRENT MEDICINAL CHEMISTRY

Dexamethasone and losartan combination treatment protected cigarette smoke-induced COPD in rats

(2020) Samia S Sokar et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract

(2020) Eun Suk Son et al.   TOXICOLOGY IN VITRO

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

(2020) You Xu et al.   JOURNAL OF NANOBIOTECHNOLOGY

Reactive oxygen and nitrogen species and innate immune response

(2020) Saad S. Al-Shehri   BIOCHIMIE

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust

(2019) Xiaomin Hou et al.   Scientific Reports

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

ROS-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in COPD

(2019) Jing Zhu et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Molecular links between COPD and lung cancer: new targets for drug discovery?

(2019) Gaetano Caramori et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transcription inhibitors and inflammatory cell activity

(2019) Gaetano Caramori et al.   CURRENT OPINION IN PHARMACOLOGY

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

(2019) Kylie B. R. Belchamber et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

(2019) Yusuf Aydemir et al.   HEART & LUNG

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

Role of Diet in Chronic Obstructive Pulmonary Disease Prevention and Treatment

(2019) Egeria Scoditti et al.   Nutrients

The relationship between acrolein and oxidative stress in COPD: in systemic plasma and in local lung tissue

(2019) Masanori Yasuo et al.   International Journal of Chronic Obstructive Pulmonary Disease

Mechanisms of SOD1 regulation by post-translational modifications

(2019) C.J. Banks et al.   Redox Biology

Effect of doxycyline in chronic obstructive pulmonary disease - An exploratory study

(2019) Brajesh Singh et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effect of Erdosteine on COPD Exacerbations in COPD Patients with Moderate Airflow Limitation

(2019) Peter MA Calverley et al.   International Journal of Chronic Obstructive Pulmonary Disease

PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice

(2018) Vivek Dharwal et al.   BIOCHEMICAL PHARMACOLOGY

Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats

(2018) Luiz Philippe S. Sergio et al.   EXPERIMENTAL LUNG RESEARCH

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

(2018) Orrette R Wauchope et al.   NUCLEIC ACIDS RESEARCH

Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease

(2018) Samia Boukhenouna et al.   Oxidative Medicine and Cellular Longevity

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

(2018) Ulrike Topf et al.   Nature Communications

Breathomics for Assessing the Effects of Treatment and Withdrawal With Inhaled Beclomethasone/Formoterol in Patients With COPD

(2018) Paolo Montuschi et al.   Frontiers in Pharmacology

The DNA Repair Transcriptome in Severe COPD

(2018) Maor Sauler et al.   EUROPEAN RESPIRATORY JOURNAL

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

Oxidative stress and macrophages: driving forces behind exacerbations of asthma and COPD?

(2018) Linsey Elisabeth Susan de Groot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Breaking news: DNA damage and repair pathways in COPD and implications for pathogenesis and treatment

(2018) Ian M. Adcock et al.   EUROPEAN RESPIRATORY JOURNAL

Adipose oxidative stress and protein carbonylation

(2018) Amy K Hauck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of xanthine oxidase (XO) on hemolytic diseases

(2018) Heidi M. Schmidt et al.   Redox Biology

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

(2018) Kamal Dua et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study

(2017) Roberto W. Dal Negro et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

(2017) Philip M. Hansbro et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Doxycycline as an anti-inflammatory agent: updates in dermatology

(2017) M. Henehan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

(2017) Ilaria Marrocco et al.   Oxidative Medicine and Cellular Longevity

Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

(2017) Anna Salazar-Degracia et al.   PeerJ

Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms

(2017) Adam McGuinness et al.   Journal of Clinical Medicine

Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells

(2017) Ryan D. Huff et al.   PLoS One

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria

(2016) Anurag Agrawal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of reactive oxygen species in mast cell degranulation

(2016) M. A. Chelombitko et al.   BIOCHEMISTRY-MOSCOW

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

(2016) Joseph Footitt et al.   CHEST

Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology

(2016) Hazel M Girvan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Co-spray dried resveratrol and budesonide inhalation formulation for reducing inflammation and oxidative stress in rat alveolar macrophages

(2016) Valentina Trotta et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring

(2016) Wojciech Łuczaj et al.   FREE RADICAL RESEARCH

Extracellular Superoxide Dismutase Enhances Recruitment of Immature Neutrophils to the Liver

(2016) Timothy J. Break et al.   INFECTION AND IMMUNITY

Overview on Peroxiredoxin

(2016)   MOLECULES AND CELLS

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

(2016) Nathaniel Teng et al.   REDOX REPORT

COPD is characterized by increased detection ofHaemophilus influenzae,Streptococcus pneumoniaeand a deficiency ofBacillusspecies

(2016) Jodie L. Simpson et al.   RESPIROLOGY

COPD immunopathology

(2016) Gaetano Caramori et al.   Seminars in Immunopathology

Clinical Relevance of Biomarkers of Oxidative Stress

(2015) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory effects of targeted lung denervation in patients with COPD

(2015) Loes E.M. Kistemaker et al.   EUROPEAN RESPIRATORY JOURNAL

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice

(2015) Mathieu C. Morissette et al.   EUROPEAN RESPIRATORY JOURNAL

Ultrasensitive UPLC–MS/MS method for analysis of etheno-DNA adducts in human white blood cells

(2015) H. Li et al.   FREE RADICAL RESEARCH

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

(2015) Coen H. Wiegman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The relationship between COPD and lung cancer

(2015) A.L. Durham et al.   LUNG CANCER

Effect of Ambroxol and Beclomethasone on Lipopolysaccharide-Induced Nitrosative Stress in Bronchial Epithelial Cells

(2015) Fabio L.M. Ricciardolo et al.   RESPIRATION

Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats

(2015) Zhihai Chen et al.   Environmental Health and Preventive Medicine

Tiotropium effects on airway inflammatory events in the cat as an animal model for acute cigarette smoke-induced lung inflammation

(2014) Saeed Kolahian et al.   EXPERIMENTAL LUNG RESEARCH

Reduced myotube diameter, atrophic signalling and elevated oxidative stress in cultured satellite cells from COPD patients

(2014) Pascal Pomiès et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effect of Clarithromycin on Lung Inflammation and Alveolar Macrophage Function inKlebsiella pneumoniaeB5055-Induced Acute Lung Infection in BALB/c mice

(2014) V. Kumar et al.   JOURNAL OF CHEMOTHERAPY

Protein Redox Modification as a Cellular Defense Mechanism against Tissue Ischemic Injury

(2014) Liang-Jun Yan   Oxidative Medicine and Cellular Longevity

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial

(2014) Jodie L. Simpson et al.   PLoS One

Feasibility of 8-OHdG formation and hOGG1 induction in PBMCs for assessing oxidative DNA damage in the lung of COPD patients

(2014) Shifang Yang et al.   RESPIROLOGY

Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial

(2014) Jin-Ping Zheng et al.   Lancet Respiratory Medicine

Relationship between exhaled nitric oxide and the frequency of severe acute exacerbation of COPD: 3-year follow-up

(2013) Balázs Antus et al.   ACTA PHYSIOLOGICA HUNGARICA

High-Dose N-Acetylcysteine in Stable COPD

(2013) Hoi Nam Tse et al.   CHEST

Antioxidants and Mucolytics in COPD Management: When (if ever) and in Whom?

(2013) Georgios Hillas et al.   CURRENT DRUG TARGETS

Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD

(2013) Esther Barreiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Species in Peripheral Blood and Sputum Neutrophils During Bacterial and Nonbacterial Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Mindaugas Vaitkus et al.   INFLAMMATION

Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD

(2013) Jodie L. Simpson et al.   MEDIATORS OF INFLAMMATION

P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence

(2013) Hongwei Yao et al.   PLoS One

Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice

(2013) Craig M Patterson et al.   RESPIRATORY RESEARCH

Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde

(2013) Balazs Antus et al.   RESPIROLOGY

Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts

(2012) Hisatoshi Sugiura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lung Oxidative Damage by Hypoxia

(2012) O. F. Araneda et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress in COPD Patients, Smokers and Non-Smokers Subjects

(2012) Heidar Tavilani et al.   Respiratory Care

Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation

(2012) Flávia Castro Ribas Souza et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain

(2011) Jennifer L. Meitzler et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

(2011) Michael Seimetz et al.   CELL

Plasma Antioxidants Are Associated with Impaired Lung Function and COPD Exacerbations in Smokers

(2011) Michael E. Nicks et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study

(2011) A. H. Agler et al.   THORAX

Is coenzyme Q a key factor in aging?

(2010) Guillermo López-Lluch et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nitric Oxide Synthase Isoenzyme Expression and Activity in Peripheral Lung Tissue of Patients with Chronic Obstructive Pulmonary Disease

(2009) Caterina Brindicci et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bronchial nitric oxide is related to symptom relief during fluticasone treatment in COPD

(2009) L. Lehtimaki et al.   EUROPEAN RESPIRATORY JOURNAL

Fluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitis

(2009) Tjard Schermer et al.   RESPIRATORY MEDICINE

Anti-Inflammatory Effects of Combined Budesonide/Formoterol in COPD Exacerbations

(2008) Erik Bathoorn et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

(2008) Jin-Ping Zheng et al.   LANCET

Azithromycin reduces airway inflammation in a murine model of lung ischaemia reperfusion injury

(2008) Nele Geudens et al.   TRANSPLANT INTERNATIONAL

Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: A prospective study

(2008) Ken M. Kunisaki et al.   Therapeutic Advances in Respiratory Disease