COPD immunopathology

Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema

(2016) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways

(2016) Simon C Rowan et al.   Lancet Respiratory Medicine

Role of B Cell–Activating Factor in Chronic Obstructive Pulmonary Disease

(2015) Leen J. M. Seys et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke–induced Lymphoid Neogenesis

(2015) Abraham B. Roos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

B Cell–Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease

(2015) Francesca Polverino et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disruption of Th17/Treg Balance in the Sputum of Patients With Chronic Obstructive Pulmonary Disease

(2015) Haijun Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Managing the safety of inhaled corticosteroids in COPD and the risk of pneumonia

(2015) Adamantia Liapikou et al.   Expert Opinion On Drug Safety

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

(2015) Coen H. Wiegman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COPD: balancing oxidants and antioxidants

(2015) Bernard Fischer et al.   International Journal of Chronic Obstructive Pulmonary Disease

The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma

(2015) Richard Hewitt et al.   Therapeutic Advances in Respiratory Disease

T-Regulatory Cells and Programmed Death 1+T Cells Contribute to Effector T-Cell Dysfunction in Patients with Chronic Obstructive Pulmonary Disease

(2014) Suresh Gopi Kalathil et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Integrative genomics of chronic obstructive pulmonary disease

(2014) Brian D. Hobbs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute COPD Exacerbations

(2014) Jadwiga A. Wedzicha et al.   CLINICS IN CHEST MEDICINE

COPD in nonsmokers: the biomass hypothesis - to be or not to be?

(2014) L. Gnatiuc et al.   EUROPEAN RESPIRATORY JOURNAL

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients

(2014) Mirella Profita et al.   IMMUNOBIOLOGY

Overexpression of CD163, CD204 and CD206 on Alveolar Macrophages in the Lungs of Patients with Severe Chronic Obstructive Pulmonary Disease

(2014) Yoichiro Kaku et al.   PLoS One

Decreased Maturation of Dendritic Cells in the Central Airways of COPD Patients Is Associated with VEGF, TGF-� and Vascularity

(2014) Andrea Zanini et al.   RESPIRATION

Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD

(2014) Paul Stoll et al.   RESPIRATORY RESEARCH

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

(2014) Antonino Di Stefano et al.   THORAX

Chemosensory Functions for Pulmonary Neuroendocrine Cells

(2013) Xiaoling Gu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease

(2013) Thérèse S. Lapperre   ANNALS OF INTERNAL MEDICINE

T Helper 17 Cells in Airway Diseases

(2013) Rabih Halwani et al.   CHEST

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Asthma and Chronic Obstructive Pulmonary Disease

(2013) Dirkje S. Postma et al.   CLINICS IN CHEST MEDICINE

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Chemokines and Chemokine Receptors Blockers as New Drugs for the Treatment of Chronic Obstructive Pulmonary Disease

(2013) G. Caramori et al.   CURRENT MEDICINAL CHEMISTRY

Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease

(2013) Kirandeep K. Chana et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial

(2013) Marek Lommatzsch et al.   RESPIRATORY RESEARCH

Imbalance between subpopulations of regulatory T cells in COPD

(2013) Jia Hou et al.   THORAX

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

(2012) Craig J Galbán et al.   NATURE MEDICINE

Distribution of γδ and other T-lymphocyte subsets in patients with chronic obstructive pulmonary disease and asthma

(2012) Daiva Urboniene et al.   RESPIRATORY MEDICINE

Decreased indoleamine 2,3-dioxygenase activity and IL-10/IL-17A ratio in patients with COPD

(2012) Kittipong Maneechotesuwan et al.   THORAX

Oxidative Stress–induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease

(2011) Paul A. Kirkham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of IL-17 in chronic inflammation in the human lung

(2011) Carol Pridgeon et al.   CLINICAL SCIENCE

Mechanisms of Altered Cell Immunity and Cytotoxicity in COPD

(2011) M. Tsoumakidou et al.   CURRENT DRUG TARGETS

Pulmonary Hypertension in COPD: Pathophysiology and Therapeutic Targets

(2011) E. Zakynthinos et al.   CURRENT DRUG TARGETS

Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study

(2011) Andrea S Gershon et al.   LANCET

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Convergent Sets of Data from In Vivo and In Vitro Methods Point to an Active Role of Hsp60 in Chronic Obstructive Pulmonary Disease Pathogenesis

(2011) Francesco Cappello et al.   PLoS One

High-Resolution Computed Tomography Quantitation of Emphysema Is Correlated with Selected Lung Function Values in Stable COPD

(2011) Silvestro Ennio D’Anna et al.   RESPIRATION

Reduced apoptosis of CD8+ T-Lymphocytes in the airways of smokers with mild/moderate COPD

(2011) Liboria Siena et al.   RESPIRATORY MEDICINE

A Novel Insight into Adaptive Immunity in Chronic Obstructive Pulmonary Disease

(2010) Francesca Polverino et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate and Adaptive Interleukin-17–producing Lymphocytes in Chronic Inflammatory Lung Disorders

(2010) Bart M. Vanaudenaerde et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Cells Expressing IL-17A and IL-17F in the Lungs of Patients With COPD

(2010) Amanda Eustace et al.   CHEST

Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients

(2010) J. Olloquequi et al.   EUROPEAN RESPIRATORY JOURNAL

Differential lymphocyte infiltration in small airways and lung parenchyma in COPD patients

(2010) Jordi Olloquequi et al.   RESPIRATORY MEDICINE

Decreased Small Airway and Alveolar CD83+ Dendritic Cells in COPD

(2009) Maria Tsoumakidou et al.   CHEST

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

(2009) A. Di Stefano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary Disease

(2009) Joan Albert Barberà et al.   DRUGS

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

(2009) G. G. Brusselle et al.   EUROPEAN RESPIRATORY JOURNAL

T-regulatory cells in COPD or tumour environment

(2009) J. Domagala-Kulawik et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic manifestations and comorbidities of COPD

(2009) P. J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients

(2009) Gaetano Caramori et al.   HISTOPATHOLOGY

Decreased Sputum Mature Dendritic Cells in Healthy Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2009) Maria Tsoumakidou et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

CD57+ T lymphocytes and functional immune deficiency

(2009) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

MUC5B Is the Major Mucin in the Gel Phase of Sputum in Chronic Obstructive Pulmonary Disease

(2008) Sara Kirkham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Pathology of Chronic Obstructive Pulmonary Disease

(2008) James C. Hogg et al.   Annual Review of Pathology-Mechanisms of Disease

Tc2 Response at the Onset of COPD Exacerbations

(2008) Demosthenes Makris et al.   CHEST

Decreased FOXP3 expression in small airways of smokers with COPD

(2008) S. Isajevs et al.   EUROPEAN RESPIRATORY JOURNAL

Decreased Airway Expression of Vascular Endothelial Growth Factor in Cigarette Smoke-Induced Emphysema in Mice and COPD Patients

(2008) Masaru Suzuki et al.   INHALATION TOXICOLOGY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking

(2007) B. Barcelo et al.   EUROPEAN RESPIRATORY JOURNAL