The Enzymatic and Non-Enzymatic Function of Myeloperoxidase (MPO) in Inflammatory Communication

The role of myeloperoxidase (MPO) in biomolecule modification, chronic inflammation and disease.

(2020) Michael Davies Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification

(2020) Huan Cai et al.   Scientific Reports

Untangling “NETosis” from NETs

(2019) Shida Yousefi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis

(2019) David Cheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

(2019) Huan Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction

(2019) Ziwen Li et al.   EUROPEAN HEART JOURNAL

Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment

(2019) Richard A. Maki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

(2018) Belal Chami et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge

(2018) Kashish Manchanda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An update on the role of epigenetics in systemic vasculitis

(2018) Patrick Coit et al.   CURRENT OPINION IN RHEUMATOLOGY

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk: A meta-analysis with 7420 cases and 9132 controls

(2018) Xin Pan et al.   Journal of Cancer Research and Therapeutics

Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease

(2018) Guisong Wang et al.   PLoS One

Chlorination and oxidation of human plasma fibronectin by myeloperoxidase-derived oxidants, and its consequences for smooth muscle cell function

(2018) Tina Nybo et al.   Redox Biology

Ensembl 2019

(2018) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells

(2017) Gouri Yogalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation

(2017) Irina Grishkovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis

(2017) Maurício Domingues-Ferreira et al.   Revista da Sociedade Brasileira de Medicina Tropical

Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage

(2017) Nura Schürmann et al.   Nature Microbiology

Myeloperoxidase genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children

(2016) Ken-Pen Weng et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Role of Myeloperoxidase in Patients with Chronic Kidney Disease

(2016) Bojana Kisic et al.   Oxidative Medicine and Cellular Longevity

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture

(2016) Nathaniel Teng et al.   REDOX REPORT

Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons

(2016) Thomas M. Jeitner et al.   TOXICOLOGICAL SCIENCES

Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

(2016) Jiajin Yang et al.   Clinical Epigenetics

Primary immune deficiencies with defects in neutrophil function

(2016) M. C. Dinauer   Hematology-American Society of Hematology Education Program

T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys319 in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

(2016) Richard P. Laura et al.   PLoS One

Myeloperoxidase Propagates Damage and is a Potential Therapeutic Target for Subacute Stroke

(2015) Reza Forghani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography—The LURIC study

(2014) Hubert Scharnagl et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Myeloperoxidase is Critically Linked to the Development of Diastolic Heart Failure Following Pressure Overload

(2014) F.G. Deuschl et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Red blood cells serve as intravascular carriers of myeloperoxidase

(2014) Matti Adam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B

(2014) H Itonaga et al.   LEUKEMIA

Eosinophilic Granulomatosis with Polyangiitis: An Overview

(2014) Andrea Gioffredi et al.   Frontiers in Immunology

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function

(2013) D. Odobasic et al.   BLOOD

Myeloperoxidase induces the priming of platelets

(2013) H. Kolarova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Common Genetic Variants in the Myeloperoxidase and Paraoxonase Genes and the Related Cancer Risk: A Review

(2013) ARSENIY E. YUZHALIN et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo

(2013) Andreas Üllen et al.   PLoS One

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Association of myeloperoxidase with ovarian cancer

(2013) Dan Cacsire Castillo-Tong et al.   TUMOR BIOLOGY

Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps

(2013) Heather Parker et al.   Frontiers in Immunology

Myeloperoxidase: A Leukocyte-Derived Protagonist of Inflammation and Cardiovascular Disease

(2012) Claudia Nussbaum et al.   ANTIOXIDANTS & REDOX SIGNALING

Proconvertase proteolytic processing of an enzymatically active myeloperoxidase precursor

(2012) Sally McCormick et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

(2012) H. Guo et al.   BLOOD

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Activation of PAD4 in NET formation

(2012) Amanda S. Rohrbach et al.   Frontiers in Immunology

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

(2011) Eike-Christin von Leitner et al.   CIRCULATION

Myeloperoxidase deficiency preserves vasomotor function in humans

(2011) Tanja K. Rudolph et al.   EUROPEAN HEART JOURNAL

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Depletion Reduces Blood-Brain Barrier Breakdown, Axon Injury, and Inflammation After Intracerebral Hemorrhage

(2011) Iska Moxon-Emre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Myeloperoxidase: An Oxidative Pathway for Generating Dysfunctional High-Density Lipoprotein

(2010) Baohai Shao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Use of Myeloperoxidase for Risk Stratification in Acute Heart Failure

(2010) T. Reichlin et al.   CLINICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation

(2010) Volker Rudolph et al.   NATURE MEDICINE

Neutrophil Extracellular Traps: How to Generate and Visualize Them

(2010) Volker Brinkmann et al.   Jove-Journal of Visualized Experiments

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

(2009) Betty S. van der Veen et al.   ANTIOXIDANTS & REDOX SIGNALING

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

(2008) Michael J. Davies et al.   ANTIOXIDANTS & REDOX SIGNALING

Aberrant Expression of Myeloperoxidase in Astrocytes Promotes Phospholipid Oxidation and Memory Deficits in a Mouse Model of Alzheimer Disease

(2008) Richard A. Maki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Activity and Microglial Expression of Myeloperoxidase in Demyelinated Cerebral Cortex in Multiple Sclerosis

(2007) Elizabeth Gray et al.   BRAIN PATHOLOGY

RETRACTED: Activation and silencing of matrix metalloproteinases

(2007) X FU et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY