Emerging pathogenic links between microbiota and the gut–lung axis

Characterisation of the gastrointestinal mucosa-associated microbiota: a novel technique to prevent cross-contamination during endoscopic procedures

(2016) E. R. Shanahan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

The Microbiome in Cystic Fibrosis

(2016) Yvonne J. Huang et al.   CLINICS IN CHEST MEDICINE

Control of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5 1A

(2016) Angélica T. Vieira et al.   MICROBES AND INFECTION

Modulating the human microbiome with live biotherapeutic products: intellectual property landscape

(2016) Xiaowei Sun et al.   NATURE REVIEWS DRUG DISCOVERY

Allergic Patients with Long-Term Asthma Display Low Levels of Bifidobacterium adolescentis

(2016) Arancha Hevia et al.   PLoS One

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells

(2016) Khiyam Hussain et al.   Frontiers in Immunology

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals

(2016) Kate L. Ormerod et al.   Microbiome

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

(2016) Robert P. Dickson et al.   Nature Microbiology

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

(2016) Leopoldo N. Segal et al.   Nature Microbiology

Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project

(2016) Xing Hua et al.   EBioMedicine

Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

(2015) Lillian Jespersen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of cigarette smoke condensate on the production and characterization of exopolysaccharides by Bifidobacterium

(2015) Jinqiang Hu et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6

(2015) L. Orivuori et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut

(2015) Liesbeth Allais et al.   ENVIRONMENTAL MICROBIOLOGY

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

The Altered Schaedler Flora: Continued Applications of a Defined Murine Microbial Community

(2015) Meghan Wymore Brand et al.   ILAR JOURNAL

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Chronic obstructive pulmonary disease and asthma-associated Proteobacteria, but not commensalPrevotellaspp., promote Toll-like receptor 2-independent lung inflammation and pathology

(2015) Jeppe M. Larsen et al.   IMMUNOLOGY

Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

(2015) Stefanie Gauguet et al.   INFECTION AND IMMUNITY

Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases

(2015) Shannon L. Russell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

(2015) Katrin N. Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Use of Germ-Free Animal Models in Microbiota-Related Research

(2015) Maha Al-Asmakh et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Consecutive oral administration ofBifidobacterium longumMM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model

(2015) Tomohiro Kawahara et al.   MICROBIOLOGY AND IMMUNOLOGY

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Anti-Inflammatory Effects of Lactobacillus Rahmnosus and Bifidobacterium Breve on Cigarette Smoke Activated Human Macrophages

(2015) Esmaeil Mortaz et al.   PLoS One

Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression

(2015) Fei Huang et al.   PLoS One

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

(2015) Christine M. Bassis et al.   mBio

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice

(2015) Koichi Tomoda et al.   BMC Pulmonary Medicine

Helicobacter pylori neutrophil-activating protein: a potential Treg modulator suppressing allergic asthma?

(2015) Anjna Sehrawat et al.   Frontiers in Microbiology

Regulation of lung immunity and host defense by the intestinal microbiota

(2015) Derrick R. Samuelson et al.   Frontiers in Microbiology

Association ofHelicobacter pyloriinfection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies

(2015) Feng Wang et al.   Infectious Diseases

The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey

(2014) Hatice Kubra Akay et al.   ANAEROBE

Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1, HWP1 and SAP2 gene expression

(2014) Abdelhabib Semlali et al.   BMC MICROBIOLOGY

Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis

(2014) Sarah King et al.   BRITISH JOURNAL OF NUTRITION

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Helminths in the hygiene hypothesis: sooner or later?

(2014) R. M. Maizels et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation

(2014) J. L. Johnson et al.   GLYCOBIOLOGY

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Early Innate Immunity to Bacterial Infection in the Lung Is Regulated Systemically by the Commensal Microbiota via Nod-Like Receptor Ligands

(2014) Thomas B. Clarke   INFECTION AND IMMUNITY

Smoking Cessation Alters Intestinal Microbiota

(2014) Luc Biedermann et al.   INFLAMMATORY BOWEL DISEASES

Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

(2014) Clarissa Schwab et al.   ISME Journal

Cigarette smoking is associated with intestinal barrier dysfunction in the small intestine but not in the large intestine of mice

(2014) Lugen Zuo et al.   Journal of Crohns & Colitis

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary Pectin–Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance ofPseudomonas aeruginosaLung Infection in Mice by Modulating Intestinal Microbiota and Immunity

(2014) Henry Bernard et al.   JOURNAL OF INFECTIOUS DISEASES

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10

(2014) D. B. Engler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From lifetime to evolution: timescales of human gut microbiota adaptation

(2014) Sara Quercia et al.   Frontiers in Microbiology

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disturbed Intestinal Integrity in Patients With COPD

(2013) Erica P.A. Rutten et al.   CHEST

Low gut microbiota diversity in early infancy precedes asthma at school age

(2013) T. R. Abrahamsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals

(2013) Nicholas P. West et al.   CLINICAL NUTRITION

Microbiota Regulates the TLR7 Signaling Pathway Against Respiratory Tract Influenza A Virus Infection

(2013) Sha Wu et al.   CURRENT MICROBIOLOGY

Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial

(2013) Raakel Luoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

(2013) Brian D. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome

(2013) Lisa Kish et al.   PLoS One

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

(2013) K. E. Fujimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation

(2013) Leopoldo N Segal et al.   Microbiome

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice

(2012) Ya-nan Li et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Cigarette Smoke Increases Staphylococcus aureus Biofilm Formation via Oxidative Stress

(2012) Ritwij Kulkarni et al.   INFECTION AND IMMUNITY

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

(2012) A. N. Thorburn et al.   JOURNAL OF IMMUNOLOGY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

(2012) Alexa A. Pragman et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

The function of our microbiota: who is out there and what do they do?

(2012) Noora Ottman et al.   Frontiers in Cellular and Infection Microbiology

Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers

(2011) Marcella Reale et al.   BRITISH JOURNAL OF NUTRITION

Treatment with specific prebiotics or probiotics prevents the development of lung emphysema in a mouse model of COPD

(2011) K.A.T. Verheijden⁎ et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Smokers with active Crohnʼs disease have a clinically relevant dysbiosis of the gastrointestinal microbiota*

(2011) Jane L. Benjamin et al.   INFLAMMATORY BOWEL DISEASES

Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy

(2011) Frederika A. van Nimwegen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient TLR Activation Restores Inflammatory Response and Ability To Control Pulmonary Bacterial Infection in Germfree Mice

(2011) C. T. Fagundes et al.   JOURNAL OF IMMUNOLOGY

Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats

(2011) Koichi Tomoda et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

(2011) Stephanie Verschuere et al.   LABORATORY INVESTIGATION

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

(2011) S Keely et al.   Mucosal Immunology

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of Succinivibrionaceae Implicated in Low Methane Emissions from Tammar Wallabies

(2011) P. B. Pope et al.   SCIENCE

Commensal Microflora Contribute to Host Defense Against Escherichia Coli Pneumonia Through Toll-Like Receptors

(2011) Lee-Wei Chen et al.   SHOCK

Harnessing Regulatory T cells to Suppress Asthma

(2010) Alison N. Thorburn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells

(2010) J. A. Preston et al.   EUROPEAN RESPIRATORY JOURNAL

Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

(2010) Yoshiyasu Ueda et al.   INTERNATIONAL IMMUNOLOGY

Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon

(2010) Daniel Aguirre de Cárcer et al.   ISME Journal

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Human Pathogens Abundant in the Bacterial Metagenome of Cigarettes

(2009) Amy R. Sapkota et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Dysregulation of gastric H,K-ATPase by cigarette smoke extract

(2009) Muna Hammadi   WORLD JOURNAL OF GASTROENTEROLOGY

Chronic LPS Inhalation Causes Emphysema-Like Changes in Mouse Lung that Are Associated with Apoptosis

(2008) David M. Brass et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability

(2008) Takuya Suzuki et al.   BRITISH JOURNAL OF NUTRITION

Assessing the diagnostic importance of nonviable bacterial cells in respiratory infections

(2008) Geraint B. Rogers et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Helicobacter pyloriColonization Is Inversely Associated with Childhood Asthma

(2008) Yu Chen et al.   JOURNAL OF INFECTIOUS DISEASES

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Temporal trends in the incidence of multiple sclerosis: A systematic review

(2008) A. Alonso et al.   NEUROLOGY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

Asthma Is Inversely Associated with Helicobacter pylori Status in an Urban Population

(2008) Joan Reibman et al.   PLoS One

Early intestinal Bacteroides fragilis colonisation and development of asthma

(2008) Carl Vael et al.   BMC Pulmonary Medicine