A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

Functional effects of the microbiota in chronic respiratory disease

(2019) Kurtis F Budden et al.   Lancet Respiratory Medicine

Interplay of microRNA-21 and Satb1 in epidermal keratinocytes during skin aging

(2019) Mohammed I. Ahmed et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Novel, Five-Marker Alternative to CD16–CD14 Gating to Identify the Three Human Monocyte Subsets

(2019) Siew-Min Ong et al.   Frontiers in Immunology

Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease

(2018) Chantal Donovan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

(2017) Philip M. Hansbro et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

(2017) Lukasz Kedzierski et al.   eLife

Changes in the number of CD31−CD45−Sca-1+ cells and Shh signaling pathway involvement in the lungs of mice with emphysema and relevant effects of acute adenovirus infection

(2017) Minhua Deng et al.   International Journal of Chronic Obstructive Pulmonary Disease

Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium

(2016) Alan C.-Y. Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model

(2016) A G Jarnicki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Animal models of COPD: What do they tell us?

(2016) Bernadette Jones et al.   RESPIROLOGY

MicroRNAs as therapeutics for future drug delivery systems in treatment of lung diseases

(2016) Kamal Dua et al.   Drug Delivery and Translational Research

Role of B Cell–Activating Factor in Chronic Obstructive Pulmonary Disease

(2015) Leen J. M. Seys et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease

(2015) Alan Chen-Yu Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis

(2015) R F Schelbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients

(2015) S. D. Pouwels et al.   EUROPEAN RESPIRATORY JOURNAL

Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats

(2015) Jiayi He et al.   FEBS LETTERS

A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease

(2015) T J Haw et al.   Mucosal Immunology

Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

(2015) Ama-Tawiah Essilfie et al.   THORAX

Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung

(2015) Hock L. Tay et al.   PLoS Pathogens

Overexpression of miR-21-5p as a predictive marker for complete tumor regression to neoadjuvant chemoradiotherapy in rectal cancer patients

(2014) Camila Miranda Lopes-Ramos et al.   BMC Medical Genomics

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Animal models of chronic obstructive pulmonary disease

(2014) Michael Fricker et al.   Expert Opinion on Drug Discovery

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

(2014) Philip M. Hansbro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers

(2014) Lihua Xie et al.   Molecular BioSystems

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic Fibrosis

(2014) Juan Zhao et al.   PLoS One

Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach

(2014) Antoine Obry et al.   PLoS One

Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma

(2013) Tae-Hyeong Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Calprotectin — A Marker of Mortality in COPD? Results from a Prospective Cohort Study

(2013) Dennis B. Holmgaard et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Murine models of infectious exacerbations of airway inflammation

(2013) Malcolm Ronald Starkey et al.   CURRENT OPINION IN PHARMACOLOGY

The emerging role of microRNAs in regulating immune and inflammatory responses in the lung

(2013) Paul S. Foster et al.   IMMUNOLOGICAL REVIEWS

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development

(2013) Zhengping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cigarette Smoke Induces Distinct Histone Modifications in Lung Cells: Implications for the Pathogenesis of COPD and Lung Cancer

(2013) Isaac K. Sundar et al.   JOURNAL OF PROTEOME RESEARCH

S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease

(2013) Alexandru Schiopu et al.   MEDIATORS OF INFLAMMATION

miR-21 Promotes Fibrogenic Epithelial-to-Mesenchymal Transition of Epicardial Mesothelial Cells Involving Programmed Cell Death 4 and Sprouty-1

(2013) Hasse Brønnum et al.   PLoS One

Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD

(2013) Katherine J Baines et al.   RESPIRATORY RESEARCH

Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation

(2013) William R. Swindell et al.   Scientific Reports

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling

(2012) Shanzhong Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent

(2012) Matteo Riva et al.   IMMUNOLOGY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease

(2012) M R Starkey et al.   Mucosal Immunology

p63 regulatesSatb1to control tissue-specific chromatin remodeling during development of the epidermis

(2011) Michael Y. Fessing et al.   JOURNAL OF CELL BIOLOGY

Satb1 Ablation Alters Temporal Expression of Immediate Early Genes and Reduces Dendritic Spine Density during Postnatal Brain Development

(2011) M. A. Balamotis et al.   MOLECULAR AND CELLULAR BIOLOGY

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

(2011) S Keely et al.   Mucosal Immunology

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

(2011) Marc Beyer et al.   NATURE IMMUNOLOGY

Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

(2010) Jay C. Horvat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

(2010) J. C. Horvat et al.   JOURNAL OF IMMUNOLOGY

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells

(2010) Rui Zhou et al.   NUCLEIC ACIDS RESEARCH

miR-21as a key regulator of oncogenic processes

(2009) S. Duygu Selcuklu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis

(2009) Julia Németh et al.   HEPATOLOGY

MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

(2009) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases

(2008) Eva Lorenz et al.   RESPIRATORY MEDICINE

Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial

(2007) David A. Morrow et al.   AMERICAN HEART JOURNAL