P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

(2013) David Dolan et al.   PLoS One

Increased DNA Damage in Progression Of COPD: A Response By Poly(ADP-Ribose) Polymerase-1

(2013) Ingrid Oit-Wiscombe et al.   PLoS One

Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair

(2013) M. Robu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD

(2012) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema

(2012) Ying Shi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Cyclin-dependent kinase inhibitor p21Waf1: Contemporary view on its role in senescence and oncogenesis

(2012) V. S. Romanov et al.   BIOCHEMISTRY-MOSCOW

Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death

(2012) Katalin Kovács et al.   FREE RADICAL BIOLOGY AND MEDICINE

DNA Damage Due to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD)

(2012) Eirini Neofytou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

p21 promotes error-free replication-coupled DNA double-strand break repair

(2012) Maurizio Mauro et al.   NUCLEIC ACIDS RESEARCH

Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation

(2011) Manabu Koike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis

(2011) Angela Rico de Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

Poly(ADP-ribose) Polymerase-1 Is a Nuclear Epigenetic Regulator of Mitochondrial DNA Repair and Transcription

(2011) A. Lapucci et al.   MOLECULAR PHARMACOLOGY

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

(2011) G. Caramori et al.   THORAX

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

(2010) Jae-woong Hwang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity

(2010) Samuel Caito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors

(2010) E. V. Efimova et al.   CANCER RESEARCH

p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1

(2010) Ornella Cazzalini et al.   DNA REPAIR

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response

(2010) Ornella Cazzalini et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

PARP1 suppresses homologous recombination events in mice in vivo

(2010) A. Claybon et al.   NUCLEIC ACIDS RESEARCH

Nuclear translocation of p21WAF1/CIP1 protein prior to its cytosolic degradation by UV enhances DNA repair and survival

(2009) Ji Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative Damage to Nucleic Acids in Severe Emphysema

(2009) Gaetan Deslee et al.   CHEST

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Poly ADP-ribose polymerase-1: An international molecule of mystery

(2008) Bethany C. Woodhouse et al.   DNA REPAIR

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C

(2008) Shuvojit Banerjee et al.   Journal of Inflammation-London

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

(2003) Utz Herbig et al.   AGING CELL