Extracellular Vesicles in Myeloid Neoplasms

Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11

(2022) Duanfeng Jiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles

(2022) Yuna Nakagawa et al.   BIOCONJUGATE CHEMISTRY

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

(2022) Bahnisikha Barman et al.   DEVELOPMENTAL CELL

ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles

(2022) Beatriz Cardeñes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells

(2022) Ana C. Viñado et al.   LEUKEMIA

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis

(2022) Yasutaka Hayashi et al.   Cell Reports

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo

(2022) Killian O’Brien et al.   Cell Reports

Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation

(2022) Xin Zhou et al.   Journal of Extracellular Vesicles

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

(2022) Simone M. Crivelli et al.   Journal of Extracellular Vesicles

Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis

(2021) Jing Wang et al.   Journal of Extracellular Vesicles

Sex-Related Differences in Chronic Myeloid Neoplasms: From the Clinical Observation to the Underlying Biology

(2021) Theodoros Karantanos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease

(2021) Dorian Forte et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance

(2021) Daniel Xin Zhang et al.   SEMINARS IN CANCER BIOLOGY

Acute myeloid leukemia: current progress and future directions

(2021) Hagop Kantarjian et al.   Blood Cancer Journal

ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells

(2021) Takahide Matsui et al.   EMBO REPORTS

Biology and clinical management of hypoplastic MDS: MDS as a bone marrow failure syndrome

(2021) Theodoros Karantanos et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

How I Treat Chronic Phase Chronic Myelogenous Leukemia

(2021) Ellin Berman   BLOOD

Updates on targeted therapies for acute myeloid leukaemia

(2021) Sabine Kayser et al.   BRITISH JOURNAL OF HAEMATOLOGY

Gender‐related differences in the outcomes and genomic landscape of patients with myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes

(2021) Theodoros Karantanos et al.   BRITISH JOURNAL OF HAEMATOLOGY

Polycythemia vera: historical oversights, diagnostic details, and therapeutic views

(2021) Ayalew Tefferi et al.   LEUKEMIA

Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

(2021) Daniel Arthur Corpuz Fisher et al.   Frontiers in Immunology

The Power of Extracellular Vesicles in Myeloproliferative Neoplasms: “Crafting” a Microenvironment That Matters

(2021) Lucia Catani et al.   Cells

Extracellular vesicles and immunogenic stress in cancer

(2021) Qi Wu et al.   Cell Death & Disease

GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

(2021) Ghulam Hassan Dar et al.   Nature Communications

An Abnormal Host/Microbiomes Signature of Plasma-Derived Extracellular Vesicles Is Associated to Polycythemia Vera

(2021) Monica Barone et al.   Frontiers in Oncology

High TSPAN8 expression in epithelial cancer cell‐derived small extracellular vesicles promote confined diffusion and pronounced uptake

(2021) Teng Wang et al.   Journal of Extracellular Vesicles

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles

(2021) Xuefeng Fei et al.   Journal of Extracellular Vesicles

Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications

(2021) Asako Shimoda et al.   Small Methods

Extracellular vesicles from myelodysplastic mesenchymal stromal cells induce DNA damage and mutagenesis of hematopoietic stem cells through miRNA transfer

(2020) Mathieu Meunier et al.   LEUKEMIA

Downregulation of extracellular vesicle microRNA‑101 derived from bone marrow mesenchymal stromal cells in myelodysplastic syndrome with disease progression

(2020) Yuu Saitoh et al.   Oncology Letters

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring

(2020) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Myelofibrosis biology and contemporary management

(2020) Naseema Gangat et al.   BRITISH JOURNAL OF HAEMATOLOGY

Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia

(2020) Rahul Kumar et al.   LEUKEMIA

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

(2020) Bong Hwan Sung et al.   Nature Communications

Circulating Small Noncoding RNAs Have Specific Expression Patterns in Plasma and Extracellular Vesicles in Myelodysplastic Syndromes and Are Predictive of Patient Outcome

(2020) Andrea Hrustincova et al.   Cells

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN

(2020) Helene Gleitz et al.   BLOOD

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

(2020) Ayuko Hoshino et al.   CELL

Targeting the Microenvironment in MDS: The Final Frontier

(2020) Patric Teodorescu et al.   Frontiers in Pharmacology

Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes

(2020) Heike Weidner et al.   JCI Insight

Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden

(2020) Theodoros Karantanos et al.   Blood Advances

RAB31 marks and controls an ESCRT-independent exosome pathway

(2020) Denghui Wei et al.   CELL RESEARCH

Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors

(2020) Claudia Cavallari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myelodysplastic Syndromes

(2020) Mario Cazzola   NEW ENGLAND JOURNAL OF MEDICINE

Primary myelofibrosis: 2021 update on diagnosis, risk‐stratification and management

(2020) Ayalew Tefferi   AMERICAN JOURNAL OF HEMATOLOGY

Clinical Insights into the Origins of Thrombosis in Myeloproliferative Neoplasms

(2020) Alison R. Moliterno et al.   BLOOD

Differential expression of circular RNAs in bone marrow‐derived exosomes from essential thrombocythemia patients

(2020) Qiang Wang et al.   CELL BIOLOGY INTERNATIONAL

Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications

(2020) Reza Jafari et al.   Journal of Translational Medicine

Vitamin K-antagonism impairs the bone marrow microenvironment and hematopoiesis

(2019) Divij Verma et al.   BLOOD

Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges

(2019) Rory M. Shallis et al.   BLOOD REVIEWS

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

(2019) Nathalie Javidi-Sharifi et al.   eLife

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

(2019) Sherif Abdelhamed et al.   EMBO REPORTS

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

The roles of JAK2 in DNA damage and repair in the myeloproliferative neoplasms: Opportunities for targeted therapy

(2018) Theodoros Karantanos et al.   BLOOD REVIEWS

Targeting the bone marrow microenvironment in acute leukemia

(2018) Christina Karantanou et al.   LEUKEMIA & LYMPHOMA

Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation

(2018) Ping Cui et al.   LEUKEMIA RESEARCH

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

Transmissible ER stress reconfigures the AML bone marrow compartment

(2018) Ben Doron et al.   LEUKEMIA

Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice

(2018) Patrice N. Wagner et al.   BLOOD

Circulating megakaryocyte and platelet microvesicles correlate with response to ruxolitinib and distinct disease severity in patients with myelofibrosis

(2018) Martina Barone et al.   BRITISH JOURNAL OF HAEMATOLOGY

Alteration of cellular and immune-related properties of bone marrow mesenchymal stem cells and macrophages by K562 chronic myeloid leukemia cell derived exosomes

(2018) Nazli Jafarzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Phosphoproteins in extracellular vesicles as candidate markers for breast cancer

(2017) I-Hsuan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

(2017) Kinsley C. French et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Observational retrospective study of vascular modulator changes during treatment in essential thrombocythemia

(2017) Andrea Piccin et al.   Translational Research

Clinical significance of circulating microparticles in Ph− myeloproliferative neoplasms

(2017) Wenjuan Zhang et al.   Oncology Letters

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

(2017) T Avril et al.   Oncogenesis

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients

(2016) Nicola Polverelli et al.   AMERICAN JOURNAL OF HEMATOLOGY

Myeloid malignancies and the microenvironment

(2016) Claudia Korn et al.   BLOOD

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

(2016) Anuradha Tarafdar et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor

(2016) Chiara Corrado et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

(2016) Noah I. Hornick et al.   Science Signaling

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

(2016) Noah I. Hornick et al.   Science Signaling

A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy

(2016) James McKiernan et al.   JAMA Oncology

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

(2016) Hong-Sheng Zhou et al.   Cancer Biology & Medicine

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients

(2016) Sandra Muntión et al.   PLoS One

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

(2015) C. Schinke et al.   BLOOD

Information transfer by exosomes: A new frontier in hematologic malignancies

(2015) Michael Boyiadzis et al.   BLOOD REVIEWS

Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

(2015) Stefania Raimondo et al.   Cell Communication and Signaling

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

(2015) J Huan et al.   LEUKEMIA

Do endothelial cells belong to the primitive stem leukemic clone in CML? Role of extracellular vesicles

(2015) Teresa L. Ramos et al.   LEUKEMIA RESEARCH

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

(2015) Antonella Caivano et al.   TUMOR BIOLOGY

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Extracellular vesicles: emerging targets for cancer therapy

(2014) Pieter Vader et al.   TRENDS IN MOLECULAR MEDICINE

Phospholipid-dependent procoagulant activity is highly expressed by circulating microparticles in patients with essential thrombocythemia

(2013) Marina Marchetti et al.   AMERICAN JOURNAL OF HEMATOLOGY

The biology and clinical impact of genetic lesions in myeloid malignancies

(2013) R. C. Lindsley et al.   BLOOD

JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes

(2013) E. Rumi et al.   BLOOD

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Anti-transforming growth factor-β therapy in patients with myelofibrosis

(2013) John Mascarenhas et al.   LEUKEMIA & LYMPHOMA

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow cytometry demonstrates differences in platelet reactivity and microparticle formation in subjects with thrombocytopenia or thrombocytosis due to primary haematological disorders

(2013) David E. Connor et al.   THROMBOSIS RESEARCH

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

(2012) J. Huan et al.   CANCER RESEARCH

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

(2011) Marco Mineo et al.   ANGIOGENESIS

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia

(2009) M. C. Trappenburg et al.   HAEMATOLOGICA

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells

(2008) L. Jin et al.   MOLECULAR CANCER THERAPEUTICS