MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

(2021) Aimy Sebastian et al.   Cells

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

(2021) Peter Geon Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo

(2021) Johann-Christoph Jann et al.   Nature Communications

Identification of potential specific biomarkers and key signaling pathways between osteogenic and adipogenic differentiation of hBMSCs for osteoporosis therapy

(2020) Jianjun Wu et al.   Journal of Orthopaedic Surgery and Research

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mesenchymal niche in MDS

(2019) Eline Pronk et al.   BLOOD

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

(2019) Fumio Nakahara et al.   NATURE CELL BIOLOGY

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

(2018) Masanari Seike et al.   GENES & DEVELOPMENT

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation

(2018) Reina Nagase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The microenvironment in myelodysplastic syndromes: Niche-mediated disease initiation and progression

(2017) Allison J. Li et al.   EXPERIMENTAL HEMATOLOGY

High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis

(2017) K C Kawabata et al.   LEUKEMIA

Myelodysplastic syndromes and bone loss in mice and men

(2017) H Weidner et al.   LEUKEMIA

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Extracellular vesicle-mediated cell–cell communication in haematological neoplasms

(2017) Junko H. Ohyashiki et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

(2016) Hiroto Horiguchi et al.   HAEMATOLOGICA

Versatile roles of extracellular vesicles in cancer

(2016) Nobuyoshi Kosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

The emerging roles of exosomes in leukemogeneis

(2016) Jianbiao Zhou et al.   Oncotarget

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

(2016) Hiroto Horiguchi et al.   HAEMATOLOGICA

Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome

(2015) S. R. Balderman et al.   BLOOD

The parathyroid hormone-regulated transcriptome in osteocytes: Parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function

(2015) Hillary C. St. John et al.   BONE

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

(2015) Ioannis S. Vlachos et al.   NUCLEIC ACIDS RESEARCH

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Impaired Proliferative Potential of Bone Marrow Mesenchymal Stromal Cells in Patients with Myelodysplastic Syndromes Is Associated with Abnormal WNT Signaling Pathway

(2014) Konstantia Pavlaki et al.   STEM CELLS AND DEVELOPMENT

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

(2014) Goro Sashida et al.   Nature Communications

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells

(2013) S Geyh et al.   LEUKEMIA

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

LNGFR+THY-1+VCAM-1hi+ Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells

(2013) Yo Mabuchi et al.   Stem Cell Reports

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

(2012) Bin Zhang et al.   CANCER CELL

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

(2012) J. Huan et al.   CANCER RESEARCH

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Bone and the hematopoietic niche: a tale of two stem cells

(2011) P. Bianco   BLOOD

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

(2011) Zhi-Gang Zhao et al.   CANCER LETTERS

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs

(2011) Robert Jan Lebbink et al.   PLoS One

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

(2010) Y. Nakamura et al.   BLOOD

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Optimization of a microRNA expression vector for function analysis of microRNA

(2010) Norihisa Furukawa et al.   JOURNAL OF CONTROLLED RELEASE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

BMP4 regulates the hematopoietic stem cell niche

(2009) D. C. Goldman et al.   BLOOD

Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells

(2009) F. Philipp Seib et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Reserves, Functional, Immunoregulatory, and Cytogenetic Properties of Bone Marrow Mesenchymal Stem Cells in Patients with Myelodysplastic Syndromes

(2009) Mirjam Klaus et al.   STEM CELLS AND DEVELOPMENT

Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression

(2008) Christoph Bergmann et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells and unwitting host to molecular parasites

(2008) Y Shiozawa et al.   LEUKEMIA

Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells

(2008) Eugenia Flores-Figueroa et al.   LEUKEMIA RESEARCH

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE