Targeting the bone marrow microenvironment in acute leukemia

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

(2017) Zhihong Zeng et al.   HAEMATOLOGICA

The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression

(2017) M Abraham et al.   LEUKEMIA

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Mimicking the Acute Myeloid Leukemia Niche for Molecular Study and Drug Screening

(2017) Mohammad Houshmand et al.   TISSUE ENGINEERING PART C-METHODS

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

(2017) Zhihong Zeng et al.   HAEMATOLOGICA

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

(2016) Jeevisha Bajaj et al.   CANCER CELL

Chemosensitizing AML cells by targeting bone marrow endothelial cells

(2016) Raphael C. Bosse et al.   EXPERIMENTAL HEMATOLOGY

Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3

(2016) Y Wang et al.   LEUKEMIA

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

(2016) Edwin D. Hawkins et al.   NATURE

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

(2016) Genevra Pillinger et al.   Oncotarget

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

(2015) R. Polak et al.   BLOOD

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

(2015) J. Benito et al.   CLINICAL CANCER RESEARCH

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

(2015) D. S. Krause et al.   HAEMATOLOGICA

Galectin-3 mediates bone marrow microenvironment-induced drug resistance in acute leukemia cells via Wnt/β-catenin signaling pathway

(2015) Kaimin Hu et al.   Journal of Hematology & Oncology

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

(2015) C E Forristal et al.   LEUKEMIA

Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death

(2015) Elin Naderi et al.   Molecular Cancer

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

(2015) Fei Fei et al.   Oncotarget

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

(2015) D. S. Krause et al.   HAEMATOLOGICA

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition

(2015) Edward Allan R. Sison et al.   Oncotarget

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

(2015) Lyubov Zaitseva et al.   Oncotarget

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning

(2014) B. Saez et al.   BLOOD

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells

(2014) Ulrike Erb et al.   Journal of Hematology & Oncology

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

(2013) I. Ben-Batalla et al.   BLOOD

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

(2013) Y.-T. Hsieh et al.   BLOOD

In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

(2013) Peter G. Miller et al.   CANCER CELL

Cooperativity of CD44 and CD49d in Leukemia Cell Homing, Migration, and Survival Offers a Means for Therapeutic Attack

(2013) V. Singh et al.   JOURNAL OF IMMUNOLOGY

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients

(2012) R. Liersch et al.   BLOOD

Myelopoiesis is regulated by osteocytes through Gs -dependent signaling

(2012) K. Fulzele et al.   BLOOD

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

(2012) M He et al.   CELL DEATH AND DIFFERENTIATION

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

The secrets of the bone marrow niche: Metabolic priming for AML

(2012) Rushdia Z Yusuf et al.   NATURE MEDICINE

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event

(2010) R Quéré et al.   LEUKEMIA

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo

(2009) A. B. Salter et al.   BLOOD

Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia

(2008) P. S. Becker et al.   BLOOD

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD