VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

(2021) Mikin R. Patel et al.   Cell Reports

Small RNAs are modified with N-glycans and displayed on the surface of living cells

(2021) Ryan A. Flynn et al.   CELL

The Interactome of the VAP Family of Proteins: An Overview

(2021) Christina James et al.   Cells

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles

(2020) Jason E. Lee et al.   SCIENCE

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells

(2020) Rocco Lucero et al.   Cell Reports

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A lipidome atlas in MS-DIAL 4

(2020) Hiroshi Tsugawa et al.   NATURE BIOTECHNOLOGY

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation

(2020) Vincent Mercier et al.   NATURE CELL BIOLOGY

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

(2020) Ann L. Wozniak et al.   JOURNAL OF CELL BIOLOGY

ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sorting

(2020) Lucas Albacete-Albacete et al.   JOURNAL OF CELL BIOLOGY

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

(2020) Sourish Ghosh et al.   CELL

Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides

(2019) Franklin Wang-Ngai Chow et al.   NUCLEIC ACIDS RESEARCH

Chemotherapy-induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2

(2019) Meng Shen et al.   CANCER RESEARCH

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli

(2019) Heedoo Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An ARF6–Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles

(2019) James W. Clancy et al.   NATURE CELL BIOLOGY

Exosomes derived from miR‐375‐overexpressing human adipose mesenchymal stem cells promote bone regeneration

(2019) Si Chen et al.   CELL PROLIFERATION

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells

(2019) Xuan Deng et al.   INTERNATIONAL JOURNAL OF CANCER

YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT

(2019) Fengxia Lin et al.   Stem Cell Research & Therapy

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

(2019) Morayma M Temoche-Diaz et al.   eLife

Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis

(2019) Michael Kirmiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486

(2019) Farah Ghamloush et al.   Scientific Reports

Immune stimuli shape the small non-coding transcriptome of extracellular vesicles released by dendritic cells

(2018) Tom A. P. Driedonks et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites

(2018) Thomas Di Mattia et al.   EMBO REPORTS

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

StAR-related lipid transfer domain 11 (STARD11)–mediated ceramide transport mediates extracellular vesicle biogenesis

(2018) Masanori Fukushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

(2018) Mohashin Pathan et al.   NUCLEIC ACIDS RESEARCH

Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

(2018) Scott A. Hinger et al.   Cell Reports

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

(2018) Ni-Ting Chiou et al.   Cell Reports

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting

(2017) Pin Lu et al.   PLoS One

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

(2017) Matthew J. Shurtleff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Exosome secretion promotes chemotaxis of cancer cells

(2017) Bong Hwan Sung et al.   Cell Adhesion & Migration

Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment

(2017) Emma Bell et al.   Computational and Structural Biotechnology Journal

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90

(2017) Feng Hong et al.   PLoS One

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

Reversible HuR‐microRNA binding controls extracellular export of miR‐122 and augments stress response

(2016) Kamalika Mukherjee et al.   EMBO REPORTS

Extracellular RNAs: A Secret Arm of Immune System Regulation

(2016) Paola de Candia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Spatiotemporal Uncoupling of MicroRNA-Mediated Translational Repression and Target RNA Degradation Controls MicroRNP Recycling in Mammalian Cells

(2016) Mainak Bose et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing

(2016) Cecilia Lässer et al.   RNA Biology

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

(2016) Inés Romero-Brey et al.   Viruses-Basel

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

(2016) Pierre-Yves Mantel et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment

(2015) Liang Ge et al.   Autophagy

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity

(2015) Marion Weber-Boyvat et al.   EXPERIMENTAL CELL RESEARCH

mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells

(2015) Bahnisikha Barman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling by exosomal microRNAs in cancer

(2015) Germana Falcone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Tenascin-C and integrins in cancer

(2015) Toshimichi Yoshida et al.   Cell Adhesion & Migration

KRAS-dependent sorting of miRNA to exosomes

(2015) Diana J Cha et al.   eLife

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment

(2014) Liang Ge et al.   eLife

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

(2013) Lukas Stalder et al.   EMBO JOURNAL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data

(2012) Chong-Jian Chen et al.   BIOINFORMATICS

Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS

(2012) Michelle Demory Beckler et al.   MOLECULAR & CELLULAR PROTEOMICS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

(2010) Han-Jou Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane contacts between endosomes and ER provide sites for PTP1B–epidermal growth factor receptor interaction

(2010) Emily R. Eden et al.   NATURE CELL BIOLOGY

Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells

(2010) Maurice Jansen et al.   TRAFFIC

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments

(2009) Alexandre J.C. Quaresma et al.   EXPERIMENTAL CELL RESEARCH

Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5

(2009) Catherine Sem Wegener et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE