Cortactin promotes exosome secretion by controlling branched actin dynamics

PI(3,5)P2controls endosomal branched actin dynamics by regulating cortactin–actin interactions

(2015) Nan Hyung Hong et al.   JOURNAL OF CELL BIOLOGY

Annexin A2–dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis

(2015) Marion Gabel et al.   JOURNAL OF CELL BIOLOGY

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

ActivatingPIK3CAMutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

(2015) Christian D. Young et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

BMP-regulated exosomes fromDrosophilamale reproductive glands reprogram female behavior

(2014) Laura Corrigan et al.   JOURNAL OF CELL BIOLOGY

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Signaling inputs to invadopodia and podosomes

(2013) D. Hoshino et al.   JOURNAL OF CELL SCIENCE

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Multiple roles for the actin cytoskeleton during regulated exocytosis

(2012) Natalie Porat-Shliom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology

(2012) Kellye C. Kirkbride et al.   Cytoskeleton

Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration

(2012) P. D. Allaire et al.   JOURNAL OF CELL SCIENCE

Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones

(2012) Melissa N. Martinez et al.   JOURNAL OF LIPID RESEARCH

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Dynamin, a membrane-remodelling GTPase

(2012) Shawn M. Ferguson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

(2012) Joel R. Ho et al.   PLoS One

Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

(2012) Wei-Wei Dong   WORLD JOURNAL OF GASTROENTEROLOGY

Cortactin Controls Cell Motility and Lamellipodial Dynamics by Regulating ECM Secretion

(2011) Bong Hwan Sung et al.   CURRENT BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Cortactin

(2011) Kellye C. Kirkbride et al.   Cell Adhesion & Migration

Actin assembly controlled by GDP-Rab27a is essential for endocytosis of the insulin secretory membrane

(2010) Toshihide Kimura et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ZF21 Protein Regulates Cell Adhesion and Motility

(2010) Makoto Nagano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab27a Negatively Regulates Phagocytosis by Prolongation of the Actin-coating Stage around Phagosomes

(2010) Kunio Yokoyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia

(2010) M. Oser et al.   JOURNAL OF CELL SCIENCE

Comparative Shotgun Proteomics Using Spectral Count Data and Quasi-Likelihood Modeling

(2010) Ming Li et al.   JOURNAL OF PROTEOME RESEARCH

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis

(2010) An Hendrix et al.   JNCI-Journal of the National Cancer Institute

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering

(2009) Ze-Qiang Ma et al.   JOURNAL OF PROTEOME RESEARCH

Neuronal IP3 3-Kinase is an F-actin–bundling Protein: Role in Dendritic Targeting and Regulation of Spine Morphology

(2009) Hong W. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

(2008) G. Menasche et al.   BLOOD

Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in Lamellipodia

(2008) Liang Cai et al.   CELL

Invadopodia

(2008) Alissa M. Weaver   CURRENT BIOLOGY

A new role for cortactin in invadopodia: Regulation of protease secretion

(2008) E CLARK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Distinctive clinicopathological associations of amplification of thecortactingene at 11q13 in head and neck squamous cell carcinomas

(2008) JP Rodrigo et al.   JOURNAL OF PATHOLOGY

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon

(2008) E S Clark et al.   ONCOGENE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE