High TSPAN8 expression in epithelial cancer cell‐derived small extracellular vesicles promote confined diffusion and pronounced uptake

Emerging role of tumor microenvironment derived exosomes in therapeutic resistance and metastasis through epithelial-to-mesenchymal transition

(2021) Sekaran Balaji et al.   LIFE SCIENCES

Integrin α5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib‑resistant non‑small cell lung cancer cells

(2021) Yang Yang et al.   Oncology Letters

A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs

(2021) Xue Gong et al.   Nature Communications

Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630

(2021) Yulan Cui et al.   Frontiers in Cell and Developmental Biology

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

(2020) Bong Hwan Sung et al.   Nature Communications

Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non–small cell lung cancer after concurrent chemoradiation

(2020) Yang Liu et al.   Science Advances

Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

(2020) Manale El Kharbili et al.   Cancers

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

(2019) Milad Riazifar et al.   ACS Nano

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

(2019) Shiqi Hu et al.   ACS Nano

Cell Membrane-Coated Porphyrin Metal–Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy

(2019) Di Zhang et al.   ACS Applied Materials & Interfaces

TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner

(2019) Hong-Sheng Zhang et al.   LIFE SCIENCES

Distorted leukocyte migration, angiogenesis, wound repair and metastasis in Tspan8 and Tspan8/CD151 double knockout mice indicate complementary activities of Tspan8 and CD51

(2018) Kun Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells

(2018) Dongsic Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosomes in cancer: Small transporters with big functions

(2018) Xi Li et al.   CANCER LETTERS

Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment

(2017) Jun Lu et al.   Oncotarget

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Catching filopodia: Exosomes surf on fast highways to enter cells

(2016) Anja Schneider et al.   JOURNAL OF CELL BIOLOGY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic targeting of tetraspanin8 in epithelial ovarian cancer invasion and metastasis

(2016) C S Park et al.   ONCOGENE

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions

(2015) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding

(2015) Shijing Yue et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma

(2014) R. Koch et al.   BLOOD

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Tspan8 and CD151 promote metastasis by distinct mechanisms

(2013) Shijing Yue et al.   EUROPEAN JOURNAL OF CANCER

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unsynchronized Translational and Rotational Diffusion of Nanocargo on a Living Cell Membrane

(2012) Lehui Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

(2011) Sanyukta Rana et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

(2011) Francisco M. Vega et al.   JOURNAL OF CELL BIOLOGY

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151

(2008) Andries Zijlstra et al.   CANCER CELL