Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites

(2022) Bahnisikha Barman et al.   DEVELOPMENTAL CELL

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

(2021) Simone M. Crivelli et al.   Alzheimers Research & Therapy

Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains

(2021) Jung-Hwa Tao-Cheng et al.   Molecular Brain

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity

(2020) Ahmed Elsherbini et al.   Acta Neuropathologica Communications

Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

(2020) Tânia Soares Martins et al.   JOURNAL OF NEUROCHEMISTRY

An exosome pathway without an ESCRT

(2020) Candia M. Kenific et al.   CELL RESEARCH

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles

(2020) Andrea Dichlberger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A large scale high throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha

(2019) Nivedita Sengupta et al.   JOURNAL OF LIPID RESEARCH

Structure, functions and regulation of CERT, a lipid‐transfer protein for the delivery of ceramide at the ER–Golgi membrane contact sites

(2019) Keigo Kumagai et al.   FEBS LETTERS

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

(2019) Xue Jiang et al.   Frontiers in Cell and Developmental Biology

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

(2018) Cécile L. Bandet et al.   DIABETES

StAR-related lipid transfer domain 11 (STARD11)–mediated ceramide transport mediates extracellular vesicle biogenesis

(2018) Masanori Fukushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

(2017) Simone M. Crivelli et al.   JOURNAL OF ALZHEIMERS DISEASE

Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors

(2016) Dušan Berkeš et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

(2016) Florentine U. Rutaganira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes

(2016) Yuji Henmi et al.   MOLECULAR BIOLOGY OF THE CELL

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers

(2015) Cécile Santos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors

(2014) Cécile Santos et al.   CHEMBIOCHEM

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

(2014) Raghavendra Pralhada Rao et al.   PLoS One

Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs

(2014) Toshiyuki Yamaji et al.   PLoS One

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Phosphatidylinositol-4-phosphate: The Golgi and beyond

(2013) Maria A. De Matteis et al.   BIOESSAYS

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding

(2013) Jennifer Prashek et al.   PLoS One

Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques

(2012) Chiara Mencarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)

(2012) Toshihiko Sugiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ceramide transporter and the Goodpasture antigen binding protein: one protein - one function?

(2010) Chiara Mencarelli et al.   JOURNAL OF NEUROCHEMISTRY

Exosomes: The Trojan horses of neurodegeneration

(2008) Roberta Ghidoni et al.   MEDICAL HYPOTHESES

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE