The molecular biology and therapeutic potential of Nrf2 in leukemia

2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice

(2022) Pankaj Yadav et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of autophagy on ferroptosis in foam cells via Nrf2

(2022) Qi Peng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways

(2022) Chencen Lai et al.   Frontiers in Immunology

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

(2022) Dylan G. Ryan et al.   iScience

Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter

(2021) Arjun Singh et al.   NEUROGASTROENTEROLOGY AND MOTILITY

BDNF rescues aging-associated internal anal sphincter dysfunction

(2021) Arjun Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges

(2021) Laura Torrente et al.   Annual Review of Pharmacology and Toxicology

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

(2020) Sarah K. Madden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia

(2020) Elsa Sanchez-Lopez et al.   CELL DEATH AND DIFFERENTIATION

PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells

(2020) Cristina Banella et al.   Cancers

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

(2020) Ji Eun Jang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Keap1‐Nrf2 signaling pathway in angiogenesis and vascular diseases

(2020) Zi Guo et al.   Journal of Tissue Engineering and Regenerative Medicine

Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells

(2020) Ewa Jasek-Gajda et al.   Antioxidants

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Potential Applications of NRF2 Inhibitors in Cancer Therapy

(2019) Emiliano Panieri et al.   Oxidative Medicine and Cellular Longevity

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

Combination of ERK2 inhibitor VX-11e and voreloxin synergistically enhances anti-proliferative and pro-apoptotic effects in leukemia cells

(2019) Ewa Jasek-Gajda et al.   APOPTOSIS

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

(2019) Viraj R. Sanghvi et al.   CELL

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition

(2019) Christina G. Towers et al.   DEVELOPMENTAL CELL

Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway

(2019) Hailiang Yu et al.   Artificial Cells Nanomedicine and Biotechnology

BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling, and non-adrenergic, non-cholinergic relaxation via increased NO release

(2019) Arjun Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia

(2019) Dilara Fatma Akın-Balı et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats

(2019) Reihaneh Ebrahimi et al.   DARU-Journal of Pharmaceutical Sciences

The Role of Nrf2 Activity in Cancer Development and Progression

(2019) Alina-Andreea Zimta et al.   Cancers

Knockdown of Nrf2 inhibits angiogenesis by down-regulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditions

(2018) Yujing Huang et al.   Biochemistry and Cell Biology

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

(2018) Yuko Murakami et al.   BMC CANCER

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway

(2018) Xuling Su et al.   Oxidative Medicine and Cellular Longevity

Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells

(2018) Virginia Rubio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation

(2018) Frédéric Picou et al.   PHARMACOLOGICAL RESEARCH

TAK-733, a Selective MEK Inhibitor, Enhances Voreloxin-induced Apoptosis in Myeloid Leukemia Cells

(2018) EWA JASEK-GAJDA et al.   ANTICANCER RESEARCH

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model

(2018) Matan Nachliely et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model

(2018) Pawel Bialk et al.   Molecular Therapy-Oncolytics

Nrf2 Inhibits Periodontal Ligament Stem Cell Apoptosis under Excessive Oxidative Stress

(2017) Yanli Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

(2017) Bing Xu et al.   Cell Death & Disease

NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells

(2017) Bo-Hyun Choi et al.   Oncotarget

Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis

(2017) Qiuyue Zhao et al.   Oncotarget

Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation

(2017) Xuefen Xu et al.   Scientific Reports

Intelligent Techniques Using Molecular Data Analysis in Leukaemia: An Opportunity for Personalized Medicine Support System

(2017) Haneen Banjar et al.   Biomed Research International

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2

(2017) Sreeja Karathedath et al.   PLoS One

Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

(2016) Jingyun Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL

(2016) Hyun-Young Cha et al.   CANCER LETTERS

Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters

(2016) Xupeng Bai et al.   DRUG METABOLISM REVIEWS

Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells

(2016) Po-Min Yang et al.   LIFE SCIENCES

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of NRF2–ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells

(2016) Hui Peng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

(2016) Chao Zhang et al.   Oncotarget

Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells

(2016) JinFeng Zhang et al.   Oncotarget

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

(2016) Marta Anna Kowalik et al.   Oncotarget

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension

(2016) Liwen Li et al.   Scientific Reports

Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

(2016) Wencheng Zhou et al.   Scientific Reports

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2-Dependent Suppression of Azoxymethane/Dextran Sulfate Sodium-Induced Colon Carcinogenesis by the Cinnamon-Derived Dietary Factor Cinnamaldehyde

(2015) M. Long et al.   Cancer Prevention Research

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

(2015) Lisa K. Sha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of Nrf2 in cell proliferation and differentiation

(2015) Shohei Murakami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2

(2015) Shasha Tao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells

(2015) Sundarraj Jayakumar et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Myeloid-derived suppressor cells in B cell malignancies

(2015) Yaghoub Yazdani et al.   TUMOR BIOLOGY

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Nrf2: new insight in cell apoptosis

(2015) M Bonay et al.   Cell Death & Disease

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

(2015) Min-Che Tung et al.   Oncotarget

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1

(2015) XIULI ZHANG et al.   Molecular Medicine Reports

The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells

(2015) Sarah Arfmann-Knübel et al.   PLoS One

The PTEN/NRF2 Axis Promotes Human Carcinogenesis

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway

(2014) Xuefen Xu et al.   BIOCHEMICAL PHARMACOLOGY

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Whole Blood Transcriptional Profiling Reveals Deregulation of Oxidative and Antioxidative Defence Genes in Myelofibrosis and Related Neoplasms. Potential Implications of Downregulation of Nrf2 for Genomic Instability and Disease Progression

(2014) Hans Carl Hasselbalch et al.   PLoS One

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

(2013) Tien-Yuan Wu et al.   AAPS Journal

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation

(2013) Yoon-Jin Lee et al.   BMB Reports

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment

(2013) H. Shen et al.   DISEASES OF THE ESOPHAGUS

Oncogenic functions of the transcription factor Nrf2

(2013) Irene Gañán-Gómez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis

(2013) Joseph W. Franses et al.   INTERNATIONAL JOURNAL OF CANCER

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α

(2013) Xiangjun Ji et al.   INTERNATIONAL JOURNAL OF CANCER

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Triptolide, a Chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1α and Nrf2

(2013) Feili Chen et al.   PHARMACOGENOMICS

Regulatory T cells in chronic lymphocytic leukemia: implication for immunotherapeutic interventions

(2013) Farhad Jadidi-Niaragh et al.   TUMOR BIOLOGY

The role of natural killer T cells in B cell malignancies

(2013) Ghasem Ghalamfarsa et al.   TUMOR BIOLOGY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced frequency of NKT-like cells in patients with progressive chronic lymphocytic leukemia

(2012) Farhad Jadidi-Niaragh et al.   MEDICAL ONCOLOGY

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response

(2012) Yan Zhong et al.   MOLECULAR CARCINOGENESIS

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

(2012) S. B. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells

(2011) Irene Bobilev et al.   CANCER BIOLOGY & THERAPY

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer

(2011) Xiangdong Ma et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

(2011) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

(2011) Adam Lister et al.   Molecular Cancer

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

(2011) Han-Cheon Um et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

(2011) Tej K. Pareek et al.   Scientific Reports

The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells

(2011) Stuart A. Rushworth et al.   Cancers

PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia

(2010) Kankan Wang et al.   CANCER CELL

Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2-Related Factor 2 Mutation on the mTOR Growth Signaling Pathway

(2010) T. Shibata et al.   CANCER RESEARCH

NF-κB–Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction

(2010) Stuart A. Rushworth et al.   CANCER RESEARCH

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase-Dependent Reactive Oxygen Species Mediate Amplified TLR4 Signaling and Sepsis-Induced Mortality in Nrf2-Deficient Mice

(2010) X. Kong et al.   JOURNAL OF IMMUNOLOGY

Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer

(2010) Tsuyoshi Takahashi et al.   JOURNAL OF SURGICAL ONCOLOGY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines

(2010) G Rachakonda et al.   ONCOGENE

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration

(2010) N. Wakabayashi et al.   Science Signaling

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway

(2009) Gi-seong Shim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

(2008) G. Juliusson et al.   BLOOD

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

(2008) S. A. Rushworth et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Guidelines for the Management of Pediatric and Adult Tumor Lysis Syndrome: An Evidence-Based Review

(2008) Bertrand Coiffier et al.   JOURNAL OF CLINICAL ONCOLOGY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA