Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

Nitro-Oleic Acid Inhibits Angiotensin II–Induced Hypertension

(2010) Jifeng Zhang et al.   CIRCULATION RESEARCH

Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids

(2010) Francisco J. Schopfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophilic tuning of the chemoprotective natural product sulforaphane

(2010) Y.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1

(2009) Aimee L. Eggler et al.   BIOCHEMICAL JOURNAL

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion

(2009) Volker Rudolph et al.   CARDIOVASCULAR RESEARCH

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives

(2009) F.J. Schopfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells

(2009) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) by Nitroalkene Fatty Acids: Importance of Nitration Position and Degree of Unsaturation

(2009) Michael J. Gorczynski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transduction of Redox Signaling by Electrophile-Protein Reactions

(2009) T. K. Rudolph et al.   Science Signaling

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

(2008) Girish Rachakonda et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo

(2008) Henna-Kaisa Jyrkkänen et al.   CIRCULATION RESEARCH

Oxidative stress-inducible lentiviral vectors for gene therapy

(2008) H Hurttila et al.   GENE THERAPY

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

(2008) Ian M. Copple et al.   HEPATOLOGY

Nitro-fatty Acid Formation and Signaling

(2008) Bruce A. Freeman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase

(2008) Eric E. Kelley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction

(2008) Xiao-Jun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protein Damage by Reactive Electrophiles: Targets and Consequences

(2007) Daniel C. Liebler   CHEMICAL RESEARCH IN TOXICOLOGY