Triptolide, a Chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1α and Nrf2

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression

(2012) Wei Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs

(2012) Xin Huang et al.   LEUKEMIA & LYMPHOMA

Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy

(2012) T. Matsunaga et al.   LEUKEMIA RESEARCH

Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation

(2012) Hu Xiaowen et al.   MOLECULAR BIOLOGY REPORTS

Triptolide Cooperates With Cisplatin to Induce Apoptosis in Gemcitabine-Resistant Pancreatic Cancer

(2012) Wenbo Zhu et al.   PANCREAS

Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03

(2012) Gabriele Escherich et al.   PEDIATRIC BLOOD & CANCER

Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells

(2012) Jia Li et al.   TOXICOLOGY LETTERS

Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*

(2011) Hai-tao Meng et al.   ACTA PHARMACOLOGICA SINICA

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part II

(2011) Jacek Wilczynski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part I

(2011) Jacek Wilczynski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

(2011) S. A. Rushworth et al.   CANCER RESEARCH

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α

(2011) Chang-Wook Jung et al.   TOXICOLOGY IN VITRO

Philadelphia chromosome-positive acute lymphoblastic leukemia

(2010) Hun J. Lee et al.   CANCER

Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia

(2010) George Deeb et al.   LEUKEMIA RESEARCH

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

(2010) Zhao-Li Zhou et al.   Molecular Cancer

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE

Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines

(2010) Wu   ONCOLOGY REPORTS

Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines

(2009) Bing Xu et al.   CANCER LETTERS

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells

(2008) Arnaud Pigneux et al.   EXPERIMENTAL HEMATOLOGY

Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2

(2008) Tadashi Nagai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY