NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia

Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia

(2018) Michael Y. Choi et al.   Cell Stem Cell

The clinical significance of B-cell maturation antigen as a therapeutic target and biomarker

(2018) Eric Sanchez et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes

(2018) Peipei Lin et al.   HAEMATOLOGICA

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation

(2017) Shengtao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

(2017) J Yu et al.   LEUKEMIA

Chronic lymphocytic leukaemia

(2017) Thomas J. Kipps et al.   Nature Reviews Disease Primers

Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2

(2017) Sreeja Karathedath et al.   PLoS One

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

(2016) B. Cui et al.   BLOOD

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

p62 in Cancer: Signaling Adaptor Beyond Autophagy

(2016) Jorge Moscat et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic β-Cells

(2016) Michal Aharoni-Simon et al.   ENDOCRINOLOGY

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib

(2016) J Yu et al.   LEUKEMIA

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

(2016) Larry Mansouri et al.   SEMINARS IN CANCER BIOLOGY

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

BCL-2 inhibition impairs mitochondrial function and targets oral tongue squamous cell carcinoma

(2016) Lei Xiong et al.   SpringerPlus

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

(2010) R. P. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE

An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase

(2008) Alexander Kohlmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS