Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats

Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective

(2019) Vahideh Oveissi et al.   DARU-Journal of Pharmaceutical Sciences

Sumatriptan protects against myocardial ischaemia–reperfusion injury by inhibition of inflammation in rat model

(2019) Mohammad Sheibani et al.   INFLAMMOPHARMACOLOGY

A cAMP analog attenuates beta-amyloid (1–42)-induced mitochondrial dysfunction and spatial learning and memory deficits

(2018) Mehdi Aghsami et al.   BRAIN RESEARCH BULLETIN

Acetyl- l -carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats

(2018) Vida Bodaghi-Namileh et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

A Pharmacological Update of Ellagic Acid

(2018) José-Luis Ríos et al.   PLANTA MEDICA

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

(2018) Peng Chen et al.   Scientific Reports

The role of melatonin on chemotherapy-induced reproductive toxicity

(2017) Hamed Haghi-Aminjan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A systematic review on potential mechanisms of minocycline in kidney diseases

(2017) Hamed Haghi-Aminjan et al.   Pharmacological Reports

Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity

(2016) Mohammad Reza Sepand et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protective mechanisms of thymoquinone on methotrexate-induced intestinal toxicity in rats

(2016) MohamedA Morsy et al.   Pharmacognosy Magazine

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

(2015) Manoj Paul et al.   PLoS One

Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy

(2014) Amjid Ahad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CO-releasing molecules and increased heme oxygenase-1 induce protein S-glutathionylation to modulate NF-κB activity in endothelial cells

(2014) Po-Yen Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation

(2014) Yi Ding et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice

(2014) Kamal Razavi-Azarkhiavi et al.   PHARMACEUTICAL BIOLOGY

Impact of methotrexate on oxidative stress and apoptosis markers in psoriatic patients

(2013) Tamilselvi Elango et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The pharmacological use of ellagic acid-rich pomegranate fruit

(2013) Coskun Usta et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways

(2013) Sudeshna Mukherjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes

(2012) You-Cheng Hseu et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice

(2009) C. Girish et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial

(2008) Paul Emery et al.   LANCET

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY