The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells

(2011) Irene Bobilev et al.   CANCER BIOLOGY & THERAPY

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

(2011) S. A. Rushworth et al.   CANCER RESEARCH

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

NF-κB–Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction

(2010) Stuart A. Rushworth et al.   CANCER RESEARCH

Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1

(2010) Takuya Miyazaki et al.   CANCER SCIENCE

INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

(2010) S K Niture et al.   CELL DEATH AND DIFFERENTIATION

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Multidrug Resistance Protein 1 by Tumor Necrosis Factor   in Cultured Glial Cells: Involvement of Nuclear Factor- B and c-Jun N-Terminal Kinase Signaling Pathways

(2010) P. T. Ronaldson et al.   MOLECULAR PHARMACOLOGY

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

(2010) R. P. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide

(2009) Srabanti Rakshit et al.   APOPTOSIS

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells

(2009) Alessandro Ascione et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Δ12,14-prostaglandin J2 requires Nrf2

(2009) Simona Bancos et al.   CELLULAR IMMUNOLOGY

Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells

(2009) Hanane Akhdar et al.   EUROPEAN JOURNAL OF CANCER

Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

(2009) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy

(2009) M. Loignon et al.   MOLECULAR CANCER THERAPEUTICS

Hemin Counteracts the Repression of Bcl-2 and Nrf2 Genes and the Cell Killing Induced by Imatinib in Human Bcr-Abl(+) CML Cells

(2009) Ioannis D. Bonovolias et al.   ONCOLOGY RESEARCH

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice

(2009) Scott A. Reisman et al.   TOXICOLOGICAL SCIENCES

Increase in P-glycoprotein accompanied by activation of protein kinase Cα and NF-κB p65 in the livers of rats with streptozotocin-induced diabetes

(2008) Natsumi Kameyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

(2008) G. Juliusson et al.   BLOOD

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

(2008) S. A. Rushworth et al.   BLOOD

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

(2008) Marc A. Riedl et al.   CLINICAL IMMUNOLOGY

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

(2008) Jonathan M. Maher et al.   TOXICOLOGICAL SCIENCES

Acrolein Induces Heme Oxygenase-1 through PKC-δ and PI3K in Human Bronchial Epithelial Cells

(2007) Hongqiao Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY