Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

The Role of JNK Signalling in Responses to Oxidative DNA Damage

(2016) Zeeshan Shaukat et al.   CURRENT DRUG TARGETS

Targeting reactive oxygen species in development and progression of pancreatic cancer

(2016) Nisha Durand et al.   Expert Review of Anticancer Therapy

NFKB1: a suppressor of inflammation, ageing and cancer

(2016) Tyrell Cartwright et al.   FEBS Journal

Signaling via the NFκB system

(2016) Simon Mitchell et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor

(2015) Yin Li et al.   CURRENT CANCER DRUG TARGETS

The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

(2015) Patricia Erebi Tawari et al.   Toxicology Research

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

(2014) Jie Zha et al.   Journal of Translational Medicine

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors

(2013) Y Liu et al.   Cell Death & Disease

Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies

(2012) Concetta Conticello et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

(2012) T Yamadori et al.   ONCOGENE

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells

(2011) Bing Xu et al.   BLOOD CELLS MOLECULES AND DISEASES

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

(2011) N C Yip et al.   BRITISH JOURNAL OF CANCER

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death

(2011) Gaurav Verma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo

(2010) H. Zhang et al.   CANCER RESEARCH

TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells

(2010) Yoshikane Kikushige et al.   Cell Stem Cell

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma

(2010) Brian W. Morrison et al.   MELANOMA RESEARCH

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

(2010) Jianqing Lin et al.   PROSTATE

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

(2009) Xiaoxia Guo et al.   CANCER LETTERS

Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway

(2009) Xiao-hong Cao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

The value of proteasome inhibition in cancer

(2008) Boris Cvek et al.   DRUG DISCOVERY TODAY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE