Data mining of Saccharomyces cerevisiae mutants engineered for increased tolerance towards inhibitors in lignocellulosic hydrolysates

Metabolic engineering of Saccharomyces cerevisiae for the production of top value chemicals from biorefinery carbohydrates

(2021) Sara L. Baptista et al.   BIOTECHNOLOGY ADVANCES

CRISPRi screens reveal genes modulating yeast growth in lignocellulose hydrolysate

(2021) Friederike Gutmann et al.   Biotechnology for Biofuels

Acetic acid stress in budding yeast: from molecular mechanisms to applications

(2021) Nicoletta Guaragnella et al.   YEAST

Molecular-dynamics-simulation-guided membrane engineering allows the increase of membrane fatty acid chain length in Saccharomyces cerevisiae

(2021) Jeroen M. Maertens et al.   Scientific Reports

Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks

(2021) Felix H. Lam et al.   Science Advances

RNA sequencing reveals metabolic and regulatory changes leading to more robust fermentation performance during short-term adaptation of Saccharomyces cerevisiae to lignocellulosic inhibitors

(2021) Marlous van Dijk et al.   Biotechnology for Biofuels

A CRISPR activation and interference toolkit for industrial Saccharomyces cerevisiae strain KE6-12

(2020) Elena Cámara et al.   Scientific Reports

Nutrient-supplemented propagation of Saccharomyces cerevisiae improves its lignocellulose fermentation ability

(2020) Marlous van Dijk et al.   AMB Express

Genomic Adaptation of Saccharomyces Species to Industrial Environments

(2020) Konstantina Giannakou et al.   Frontiers in Genetics

Enhanced acetic acid stress tolerance and ethanol production in Saccharomyces cerevisiae by modulating expression of the de novo purine biosynthesis genes

(2019) Ming-Ming Zhang et al.   Biotechnology for Biofuels

Deletion of Atg22 gene contributes to reduce programmed cell death induced by acetic acid stress in Saccharomyces cerevisiae

(2019) Jingjin Hu et al.   Biotechnology for Biofuels

Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping

(2019) Jiazhang Lian et al.   Nature Communications

HAA1 and PRS3 overexpression boosts yeast tolerance towards acetic acid improving xylose or glucose consumption: unravelling the underlying mechanisms

(2018) Joana T. Cunha et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expression of Gre2p improves tolerance of engineered xylose-fermenting Saccharomyces cerevisiae to glycolaldehyde under xylose metabolism

(2018) Lahiru N. Jayakody et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The origin and adaptive evolution of domesticated populations of yeast from Far East Asia

(2018) Shou-Fu Duan et al.   Nature Communications

Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance

(2018) Maria Sardi et al.   PLoS Genetics

Genome evolution across 1,011 Saccharomyces cerevisiae isolates

(2018) Jackson Peter et al.   NATURE

Molecular and physiological basis of Saccharomyces cerevisiae tolerance to adverse lignocellulose-based process conditions

(2018) Joana T. Cunha et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Changes in lipid metabolism convey acid tolerance in Saccharomyces cerevisiae

(2018) Zhong-peng Guo et al.   Biotechnology for Biofuels

Yeast chemogenomic screen identifies distinct metabolic pathways required to tolerate exposure to phenolic fermentation inhibitors ferulic acid, 4-hydroxybenzoic acid and coniferyl aldehyde

(2018) Eugene Fletcher et al.   METABOLIC ENGINEERING

Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms

(2017) Steve Swinnen et al.   Microbial Cell Factories

Profiling of Saccharomyces cerevisiae transcription factors for engineering the resistance of yeast to lignocellulose-derived inhibitors in biomass conversion

(2017) Guochao Wu et al.   Microbial Cell Factories

Membrane engineering of S. cerevisiae targeting sphingolipid metabolism

(2017) Lina Lindahl et al.   Scientific Reports

ALD5, PAD1, ATF1 and ATF2 facilitate the catabolism of coniferyl aldehyde, ferulic acid and p-coumaric acid in Saccharomyces cerevisiae

(2017) Peter Temitope Adeboye et al.   Scientific Reports

RNA-Seq-based transcriptomic and metabolomic analysis reveal stress responses and programmed cell death induced by acetic acid in Saccharomyces cerevisiae

(2017) Yachen Dong et al.   Scientific Reports

Leveraging Genetic-Background Effects in Saccharomyces cerevisiae To Improve Lignocellulosic Hydrolysate Tolerance

(2016) Maria Sardi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of theWHI2Gene Identified through Inverse Metabolic Engineering

(2016) Yingying Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

GRE2 from Scheffersomyces stipitis as an aldehyde reductase contributes tolerance to aldehyde inhibitors derived from lignocellulosic biomass

(2016) Xu Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Flux control-based design of furfural-resistance strains of Saccharomyces cerevisiae for lignocellulosic biorefinery

(2016) Pornkamol Unrean   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae

(2016) Yingying Chen et al.   Biotechnology for Biofuels

Deletion of JJJ1 improves acetic acid tolerance and bioethanol fermentation performance of Saccharomyces cerevisiae strains

(2016) Xuechang Wu et al.   BIOTECHNOLOGY LETTERS

Protective Effects of Arginine on Saccharomyces cerevisiae Against Ethanol Stress

(2016) Yanfei Cheng et al.   Scientific Reports

Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe Vanillin Stress in Saccharomyces cerevisiae

(2016) Yoko Ishida et al.   Frontiers in Microbiology

Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose

(2016) Nileema R. Divate et al.   Bioengineered

The metabolic background is a global player in Saccharomyces gene expression epistasis

(2016) Mohammad Tauqeer Alam et al.   Nature Microbiology

Transcriptome analysis of acetic-acid-treated yeast cells identifies a large set of genes whose overexpression or deletion enhances acetic acid tolerance

(2015) Yeji Lee et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

PEP3 overexpression shortens lag phase but does not alter growth rate in Saccharomyces cerevisiae exposed to acetic acid stress

(2015) Jun Ding et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Contribution of PRS3, RPB4 and ZWF1 to the resistance of industrial Saccharomyces cerevisiae CCUG53310 and PE-2 strains to lignocellulosic hydrolysate-derived inhibitors

(2015) Joana T. Cunha et al.   BIORESOURCE TECHNOLOGY

Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation

(2015) Jose Serate et al.   Biotechnology for Biofuels

Improved growth and ethanol fermentation ofSaccharomyces cerevisiaein the presence of acetic acid by overexpression ofSET5andPPR1

(2015) Ming-Ming Zhang et al.   Biotechnology Journal

Auxotrophic Mutations Reduce Tolerance of Saccharomyces cerevisiae to Very High Levels of Ethanol Stress

(2015) Steve Swinnen et al.   EUKARYOTIC CELL

YNL134CfromSaccharomyces cerevisiaeencodes a novel protein with aldehyde reductase activity for detoxification of furfural derived from lignocellulosic biomass

(2015) Xianxian Zhao et al.   YEAST

Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp fromSaccharomyces cerevisiae

(2015) Jaewoong Moon et al.   YEAST

Improved growth and ethanol fermentation ofSaccharomyces cerevisiaein the presence of acetic acid by overexpression ofSET5andPPR1

(2015) Ming-Ming Zhang et al.   Biotechnology Journal

Overexpression of PAD1 and FDC1 results in significant cinnamic acid decarboxylase activity in Saccharomyces cerevisiae

(2015) Peter Richard et al.   AMB Express

Comparison of strategies to overcome the inhibitory effects in high-gravity fermentation of lignocellulosic hydrolysates

(2014) Charilaos Xiros et al.   BIOMASS & BIOENERGY

The Yeast Deletion Collection: A Decade of Functional Genomics

(2014) Guri Giaever et al.   GENETICS

UpSet: Visualization of Intersecting Sets

(2014) Alexander Lex et al.   IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS

Genome-wide screening of Saccharomyces cerevisiae genes required to foster tolerance towards industrial wheat straw hydrolysates

(2014) Francisco B. Pereira et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

The diverse role of Pdr12 in resistance to weak organic acids

(2014) Yvonne Nygård et al.   YEAST

Re-assessment of YAP1 and MCR1 contributions to inhibitor tolerance in robust engineered Saccharomyces cerevisiae fermenting undetoxified lignocellulosic hydrolysate

(2014) Valeria Wallace-Salinas et al.   AMB Express

3′ Truncation of theGPD1Promoter in Saccharomyces cerevisiae for Improved Ethanol Yield and Productivity

(2013) Wen-Tao Ding et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Roles of the Yap1 Transcription Factor and Antioxidants in Saccharomyces cerevisiae's Tolerance to Furfural and 5-Hydroxymethylfurfural, Which Function as Thiol-Reactive Electrophiles Generating Oxidative Stress

(2013) D. Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Impact of osmotic stress and ethanol inhibition in yeast cells on process oscillation associated with continuous very-high-gravity ethanol fermentation

(2013) Liang Wang et al.   Biotechnology for Biofuels

The influence of HMF and furfural on redox-balance and energy-state of xylose-utilizing Saccharomyces cerevisiae

(2013) Magnus Ask et al.   Biotechnology for Biofuels

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering

(2013) Mekonnen M Demeke et al.   Biotechnology for Biofuels

Bioconversion of lignocellulose: inhibitors and detoxification

(2013) Leif J Jönsson et al.   Biotechnology for Biofuels

Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae

(2013) Marlene Sousa et al.   BMC GENOMICS

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates

(2013) J. M. Skerker et al.   Molecular Systems Biology

Lignocellulosic ethanol production at high-gravity: challenges and perspectives

(2013) Rakesh Koppram et al.   TRENDS IN BIOTECHNOLOGY

An organic acid-tolerant HAA1-overexpression mutant of an industrial bioethanol strain of Saccharomyces cerevisiae and its application to the production of bioethanol from sugarcane molasses

(2013) Takuya Inaba et al.   AMB Express

Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae

(2011) Seong-Eon Park et al.   BIORESOURCE TECHNOLOGY

Engineered NADH-dependent GRE2 from Saccharomyces cerevisiae by directed enzyme evolution enhances HMF reduction using additional cofactor NADPH

(2011) Jaewoong Moon et al.   ENZYME AND MICROBIAL TECHNOLOGY

Overexpression of the yeast transcription activator Msn2 confers furfural resistance and increases the initial fermentation rate in ethanol production

(2011) Yu Sasano et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Acetate but not propionate induces oxidative stress in bakers’ yeastSaccharomyces cerevisiae

(2011) Halyna M Semchyshyn et al.   REDOX REPORT

Drug resistance marker-aided genome shuffling to improve acetic acid tolerance in Saccharomyces cerevisiae

(2010) Dao-Qiong Zheng et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid

(2010) Nuno P Mira et al.   Microbial Cell Factories

Comprehensive reanalysis of transcription factor knockout expression data in Saccharomyces cerevisiae reveals many new targets

(2010) Jüri Reimand et al.   NUCLEIC ACIDS RESEARCH

The Yap family and its role in stress response

(2010) Claudina Rodrigues-Pousada et al.   YEAST

Resistance of Saccharomyces cerevisiae to High Concentrations of Furfural Is Based on NADPH-Dependent Reduction by at Least Two Oxireductases

(2009) D. Heer et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion

(2009) Z. Lewis Liu et al.   GENE

Overexpression of Saccharomyces cerevisiae transcription factor and multidrug resistance genes conveys enhanced resistance to lignocellulose-derived fermentation inhibitors

(2009) Björn Alriksson et al.   PROCESS BIOCHEMISTRY

Multiple gene-mediated NAD(P)H-dependent aldehyde reduction is a mechanism of in situ detoxification of furfural and 5-hydroxymethylfurfural by Saccharomyces cerevisiae

(2008) Z. Lewis Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genome-wide screening of the genes required for tolerance to vanillin, which is a potential inhibitor of bioethanol fermentation, in Saccharomyces cerevisiae

(2008) Ayako Endo et al.   Biotechnology for Biofuels

Identification of furfural as a key toxin in lignocellulosic hydrolysates and evolution of a tolerant yeast strain

(2008) Dominik Heer et al.   Microbial Biotechnology