Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice

(2010) Fraser M. Rogerson et al.   ARTHRITIS AND RHEUMATISM

IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression

(2010) Miho Suzuki et al.   CYTOKINE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 as a key player in systemic inflammation and joint destruction

(2009) J.E. Fonseca et al.   AUTOIMMUNITY REVIEWS

Interleukin-6 inhibits early differentiation of ATDC5 chondrogenic progenitor cells

(2009) Shoko Nakajima et al.   CYTOKINE

Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis

(2009) Bailin Liang et al.   Journal of Inflammation-London

Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor

(2009) Jean-Michel Dayer et al.   RHEUMATOLOGY

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

(2008) Minoru Fujimoto et al.   ARTHRITIS AND RHEUMATISM

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1β

(2008) L.J. Sandell et al.   OSTEOARTHRITIS AND CARTILAGE

Molecular network of cartilage homeostasis and osteoarthritis

(2007) Megumi Hashimoto et al.   MEDICINAL RESEARCH REVIEWS