Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

The Role of Inflammation in the Pathogenesis of Osteoarthritis

(2020) Yoke Yue Chow et al.   MEDIATORS OF INFLAMMATION

Structure and Function of Human Matrix Metalloproteinases

(2020) Helena Laronha et al.   Cells

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

(2020) Doo Ri Park et al.   Nature Communications

Randomized, Double‐Blind, Placebo‐Controlled Trial of Intra‐articular CNTX ‐4975 ( trans‐ capsaicin) for Pain Associated With Osteoarthritis of the Knee

(2019) Randall M. Stevens et al.   Arthritis & Rheumatology

Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key

(2019) Paola Castrogiovanni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain

(2019) Elisa Belluzzi et al.   Biomed Research International

MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

(2019) Zafar Rasheed et al.   Scientific Reports

Runx2 plays a central role in Osteoarthritis development

(2019) Di Chen et al.   Journal of Orthopaedic Translation

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics

(2018) Nazir M. Khan et al.   PHARMACOLOGICAL RESEARCH

CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial

(2018) Y. Jin et al.   OSTEOARTHRITIS AND CARTILAGE

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis

(2018) Margreet Kloppenburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial

(2018) Elien A M Mahler et al.   ANNALS OF THE RHEUMATIC DISEASES

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

(2017) Jinan Elayyan et al.   FASEB JOURNAL

Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6 in human articular chondrocytes via TLR4/MyD88-dependent and -independent signaling cascades

(2017) Hailun Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach

(2017) Hiroshi Nara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset

(2017) Hongxin Zhang et al.   Molecular Medicine Reports

Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways

(2017) Shuan Liu et al.   Experimental and Therapeutic Medicine

LncRNA-UCA1 enhances MMP-13 expression by inhibiting miR- 204-5p in human chondrocytes

(2017) Guodong Wang et al.   Oncotarget

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

(2017) Atsushi Takahashi et al.   Scientific Reports

Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review

(2016) Carlos J. Meheux et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors

(2016) Hiroshi Nara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes

(2016) Lomeli R. Carpio et al.   CONNECTIVE TISSUE RESEARCH

Monoclonal antibodies for the treatment of osteoarthritis

(2016) Shuang Zheng et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

(2016) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes

(2016) Ronghe Gu et al.   MEDICINE

MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses

(2016) F. Meng et al.   OSTEOARTHRITIS AND CARTILAGE

The Role of MicroRNAs and Their Targets in Osteoarthritis

(2016) Gregory R. Sondag et al.   Current Rheumatology Reports

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation

(2016) Qiang Liu et al.   Scientific Reports

Biologic basis of osteoarthritis

(2015) Charles J. Malemud   CURRENT OPINION IN RHEUMATOLOGY

MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes

(2015) Lisong Li et al.   CURRENT PHARMACEUTICAL DESIGN

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

(2015) Sabrina Amar et al.   Expert Review of Proteomics

Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

(2015) Peter G. Ruminski et al.   JOURNAL OF MEDICINAL CHEMISTRY

MiR-29a and MiR-140 Protect Chondrocytes against the Anti-Proliferation and Cell Matrix Signaling Changes by IL-1β

(2015)   MOLECULES AND CELLS

Roadmap for regulation

(2015) Casey E. Romanoski et al.   NATURE

Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients

(2015) M. Fu et al.   OSTEOARTHRITIS AND CARTILAGE

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2

(2015) Shurei Sugita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alternative role of DNA methylation in splicing regulation

(2015) Galit Lev Maor et al.   TRENDS IN GENETICS

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

(2015) Erfan Aref-Eshghi et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes

(2015) Fotini Kostopoulou et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-602 and MicroRNA-608 Regulate Sonic Hedgehog Expression via Target Sites in the Coding Region in Human Chondrocytes

(2015) Nahid Akhtar et al.   Arthritis & Rheumatology

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes

(2014) Bo Yang et al.   FEBS LETTERS

The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13

(2014) Joanna-Marie Howes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model

(2014) Ryuichiro Akagi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis

(2014) Jinsoo Song et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Integrins and chondrocyte–matrix interactions in articular cartilage

(2014) Richard F. Loeser   MATRIX BIOLOGY

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

(2014) Reiji Higashiyama et al.   Modern Rheumatology

Association between adiponectin and cartilage degradation in human osteoarthritis

(2014) P.-J. Francin et al.   OSTEOARTHRITIS AND CARTILAGE

Effective knock down of MMP13 and ADAMTS5 by intra-articular injection of small interference RNA (siRNA) in a surgically induced osteoarthritis model of mice

(2014) H. Hoshi et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial

(2014) Chris Hyunchul Jo et al.   STEM CELLS

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro

(2014) FANG-JIE ZHANG et al.   Experimental and Therapeutic Medicine

Brief Report: Stress-Inducible Nuclear Protein 1 Regulates Matrix Metalloproteinase 13 Expression in Human Articular Chondrocytes

(2014) Raghunatha R. Yammani et al.   Arthritis & Rheumatology

MicroRNA-127-5p Regulates Matrix Metalloproteinase 13 Expression and Interleukin-1β-Induced Catabolic Effects in Human Chondrocytes

(2013) Su Jin Park et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity

(2013) Jinsoo Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epidemiology and burden of osteoarthritis

(2013) A. Litwic et al.   BRITISH MEDICAL BULLETIN

MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin

(2013) Jinsoo Song et al.   Cell Communication and Signaling

The expression of intronic miRNAs, miR-483 and miR-483*, and their host gene, Igf2, in murine osteoarthritis cartilage

(2013) Yuebin Qi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

(2013) Ko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes

(2013) L.A. Vonk et al.   OSTEOARTHRITIS AND CARTILAGE

On the classification of long non-coding RNAs

(2013) Lina Ma et al.   RNA Biology

Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis

(2013) Matt J. Barter et al.   Current Rheumatology Reports

Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis

(2013) Qiang Liu et al.   Arthritis & Rheumatology

Development of a Neutralizing Antibody Specific for the Active Form of Matrix Metalloproteinase-13

(2012) Shoichi Naito et al.   BIOCHEMISTRY

Inhibition Effect of Curcumin on TNF-a and MMP-13 Expression Induced by Advanced Glycation End Products in Chondrocytes

(2012) Qingshan Yang et al.   PHARMACOLOGY

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Selective non zinc binding inhibitors of MMP13

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

(2011) Miguel Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

(2011) Christian Gege et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets

(2011) Michael B. Mueller et al.   PM&R

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

(2010) Nahid Akhtar et al.   ARTHRITIS AND RHEUMATISM

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti

(2010) Steven Settle et al.   ARTHRITIS AND RHEUMATISM

Retrospective Analysis of Infection Rate After Early Reoperation in Total Hip Arthroplasty

(2010) Hussein Darwiche et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases

(2010) Takayuki Shiomi et al.   PATHOLOGY INTERNATIONAL

Is obesity a risk factor for progressive radiographic knee osteoarthritis?

(2009) J. Niu et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

(2009) Mark E. Schnute et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes

(2009) Sohee Hong et al.   FASEB JOURNAL

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Lymphoid Enhancer Binding Factor 1 Regulates Transcription through Gene Looping

(2009) K. Yun et al.   JOURNAL OF IMMUNOLOGY

N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

(2009) Elisa Nuti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13†

(2009) Lauren G. Monovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocytes

(2009) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage

(2008) M Pombo-Suarez et al.   ANNALS OF THE RHEUMATIC DISEASES

Structural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases

(2008) Loretta Aureli et al.   CURRENT MEDICINAL CHEMISTRY

Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13

(2008) Hironari Takaishi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Role of the hemopexin domain of matrix metalloproteinases in cell migration

(2008) Antoine Dufour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

(2008) Jie Jack Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

(2008) M. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL

Deadenylation is a widespread effect of miRNA regulation

(2008) A. Eulalio et al.   RNA