Osteoarthritis: toward a comprehensive understanding of pathological mechanism

PKCδnull mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

(2016) Ranjan Kc et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential roles of TGF-β signalling in joint tissues during osteoarthritis development

(2016) Ting Yu Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis

(2016) R.E. Miller et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year in review 2015: biology

(2016) A.M. Malfait   OSTEOARTHRITIS AND CARTILAGE

Aggrecan Nanoscale Solid–Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties

(2015) Hadi Tavakoli Nia et al.   ACS Nano

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

(2015) Faezeh Vasheghani et al.   ANNALS OF THE RHEUMATIC DISEASES

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand

(2015) Rui Zhang et al.   INFLAMMATION RESEARCH

Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation

(2015) BoBae Lee et al.   JOURNAL OF BIOMECHANICS

High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis

(2015) Hadi T. Nia et al.   JOURNAL OF BIOMECHANICS

Biomechanical properties of murine meniscus surface via AFM-based nanoindentation

(2015) Qing Li et al.   JOURNAL OF BIOMECHANICS

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee

(2015) Wenzel Waldstein et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inflammation in joint injury and post-traumatic osteoarthritis

(2015) J. Lieberthal et al.   OSTEOARTHRITIS AND CARTILAGE

Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies

(2015) M.C. Hochberg   OSTEOARTHRITIS AND CARTILAGE

Genome-Wide Mapping of DNA Hydroxymethylation in Osteoarthritic Chondrocytes

(2015) Sarah E. B. Taylor et al.   Arthritis & Rheumatology

Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage

(2015) Nicole A. Zelenski et al.   Arthritis & Rheumatology

Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

(2015) Elena Kozhemyakina et al.   Arthritis & Rheumatology

The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model

(2015) Beatriz Caramés et al.   Arthritis & Rheumatology

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

Novel COL9A3 mutation in a family diagnosed with multiple epiphyseal dysplasia: a case report

(2014) Changhoon Jeong et al.   BMC MUSCULOSKELETAL DISORDERS

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis

(2014) Sonia Nasi et al.   JOINT BONE SPINE

Modulation of Ten-Eleven Translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) Expression, α-Ketoglutarate (α-KG), and DNA Hydroxymethylation Levels by Interleukin-1β in Primary Human Chondrocytes

(2014) Abdul Haseeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomechanical phenotype of chondroadherin-null murine articular cartilage

(2014) Michael A. Batista et al.   MATRIX BIOLOGY

Atomic force microscopy reveals age-dependent changes in nanomechanical properties of the extracellular matrix of native human menisci: implications for joint degeneration and osteoarthritis

(2014) Jeanie Kwok et al.   Nanomedicine-Nanotechnology Biology and Medicine

Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8/A9 serum levels

(2014) R.F. Schelbergen et al.   OSTEOARTHRITIS AND CARTILAGE

Functional Annotation of Rheumatoid Arthritis and Osteoarthritis Associated Genes by Integrative Genome-Wide Gene Expression Profiling Analysis

(2014) Zhan-Chun Li et al.   PLoS One

Delayed Fracture Healing and Increased Callus Adiposity in a C57BL/6J Murine Model of Obesity-Associated Type 2 Diabetes Mellitus

(2014) Matthew L. Brown et al.   PLoS One

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

(2014) E. Thijssen et al.   RHEUMATOLOGY

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

(2014) Koji Takayama et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage

(2014) Matlock A. Jeffries et al.   Arthritis & Rheumatology

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis-like Phenotype in Mice

(2013) Jie Shen et al.   ARTHRITIS AND RHEUMATISM

High-Bandwidth AFM-Based Rheology Reveals that Cartilage is Most Sensitive to High Loading Rates at Early Stages of Impairment

(2013) Hadi Tavakoli Nia et al.   BIOPHYSICAL JOURNAL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A current review of molecular mechanisms regarding osteoarthritis and pain

(2013) Andrew S. Lee et al.   GENE

Pain assessment in animal models of osteoarthritis

(2013) Margaret J. Piel et al.   GENE

Atomic force microscopy to investigate spatial patterns of response to interleukin-1beta in engineered cartilage tissue elasticity

(2013) Leonardo Peñuela et al.   JOURNAL OF BIOMECHANICS

Atomic force microscopy reveals regional variations in the micromechanical properties of the pericellular and extracellular matrices of the meniscus

(2013) Johannah Sanchez-Adams et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology

(2013) Nadia Sassi et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase

(2013) Rebecca E. Wilusz et al.   Journal of the Mechanical Behavior of Biomedical Materials

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Nerve growth factor: an update on the science and therapy

(2013) M.F. Seidel et al.   OSTEOARTHRITIS AND CARTILAGE

Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage

(2013) R.E. Wilusz et al.   OSTEOARTHRITIS AND CARTILAGE

Association study of candidate genes for the progression of hand osteoarthritis

(2013) J. Bijsterbosch et al.   OSTEOARTHRITIS AND CARTILAGE

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma

(2013) B. Poulet et al.   OSTEOARTHRITIS AND CARTILAGE

A commentary on modelling osteoarthritis pain in small animals

(2013) A.M. Malfait et al.   OSTEOARTHRITIS AND CARTILAGE

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

A Global Increase in 5-Hydroxymethylcytosine Levels Marks Osteoarthritic Chondrocytes

(2013) Sarah E. B. Taylor et al.   Arthritis & Rheumatology

Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis

(2013) Christin M. Lepus et al.   Arthritis & Rheumatology

The growing array of innate inflammatory ignition switches in osteoarthritis

(2012) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue

(2012) Meina Wang et al.   ARTHRITIS AND RHEUMATISM

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

(2012) Blandine Poulet et al.   ARTHRITIS AND RHEUMATISM

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

(2012) Tujun Weng et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice

(2012) Craig R. Louer et al.   ARTHRITIS AND RHEUMATISM

Depth-dependent anisotropy of the micromechanical properties of the extracellular and pericellular matrices of articular cartilage evaluated via atomic force microscopy

(2012) Morgan A. McLeod et al.   JOURNAL OF BIOMECHANICS

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

(2012) Laura McKelvey et al.   JOURNAL OF NEUROCHEMISTRY

Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial

(2012) Mark T. Brown et al.   JOURNAL OF PAIN

Optimization of chondrocyte isolation and characterization for large-scale cartilage tissue engineering

(2012) Adelola O. Oseni et al.   JOURNAL OF SURGICAL RESEARCH

Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage

(2012) R. E. Wilusz et al.   Journal of the Royal Society Interface

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

(2012)   LANCET

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Syndecans in cartilage breakdown and synovial inflammation

(2012) Thomas Pap et al.   Nature Reviews Rheumatology

Viscoelasticity of the articular cartilage surface in early osteoarthritis

(2012) J. Desrochers et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells

(2012) B. O. Diekman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

(2012) Peter M van der Kraan et al.   ARTHRITIS RESEARCH & THERAPY

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Nanomechanics of the Cartilage Extracellular Matrix

(2011) Lin Han et al.   Annual Review of Materials Research

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: Effects of short-term exercise

(2011) Timothy M. Griffin et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Poroelasticity of Cartilage at the Nanoscale

(2011) Hadi Tavakoli Nia et al.   BIOPHYSICAL JOURNAL

Time-Dependent Nanomechanics of Cartilage

(2011) Lin Han et al.   BIOPHYSICAL JOURNAL

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

(2011) Priyanka Verma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury

(2011) J. Van Steenwinckel et al.   JOURNAL OF NEUROSCIENCE

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study

(2011) H. Nagashima et al.   OSTEOARTHRITIS AND CARTILAGE

Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain

(2011) T.J. Schnitzer et al.   OSTEOARTHRITIS AND CARTILAGE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity

(2011) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

(2010) Hee-Jeong Im et al.   ARTHRITIS AND RHEUMATISM

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4

(2010) Jeffrey M. Coles et al.   ARTHRITIS AND RHEUMATISM

Structural and functional changes of the articular surface in a post-traumatic model of early osteoarthritis measured by atomic force microscopy

(2010) Jane Desrochers et al.   JOURNAL OF BIOMECHANICS

The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases

(2010) Grégory Conductier et al.   JOURNAL OF NEUROIMMUNOLOGY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin–Beck disease

(2010) J.T. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

(2010) T. Tetsunaga et al.   OSTEOARTHRITIS AND CARTILAGE

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Keratinocyte-derived Chemokine in Obesity

(2009) Jaap G. Neels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli

(2009) D. L. Cecil et al.   JOURNAL OF IMMUNOLOGY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy

(2009) Martin Stolz et al.   Nature Nanotechnology

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization

(2009) A.M. Malfait et al.   OSTEOARTHRITIS AND CARTILAGE

Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes

(2009) J. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease

(2009) Ian D Welch et al.   ARTHRITIS RESEARCH & THERAPY

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

(2008) Qiuqian Wu et al.   ARTHRITIS AND RHEUMATISM

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

(2008) Wendy L Thompson et al.   Journal of Neuroinflammation

The Symptoms of Osteoarthritis and the Genesis of Pain

(2008) David J. Hunter et al.   MEDICAL CLINICS OF NORTH AMERICA

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

Nanomechanics of polymer gels and biological tissues: A critical review of analytical approaches in the Hertzian regime and beyond

(2008) David C. Lin et al.   Soft Matter

Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes

(2007) Eric M. Darling et al.   JOURNAL OF BIOMECHANICS

Aggrecan components differentially modulate nerve growth factor–responsive and neurotrophin-3-responsive dorsal root ganglion neurite growth

(2007) Carmen C. M. Chan et al.   JOURNAL OF NEUROSCIENCE RESEARCH