Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention

Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

(2022) M Alaa Terkawi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages

(2022) Kanglu Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Inflammasome Activation in the Hip Synovium of Rapidly Destructive Coxopathy Patients and Its Relationship with the Development of Synovitis and Bone Loss

(2022) Shunichi Yokota et al.   AMERICAN JOURNAL OF PATHOLOGY

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

(2022) Zhentian Wei et al.   Frontiers in Cellular and Infection Microbiology

The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature

(2021) Cécile Lambert et al.   Frontiers in Medicine

Effect of Platelet-Rich Plasma on M1/M2 Macrophage Polarization

(2021) Ryoka Uchiyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial

(2021) Rafael Fortuna et al.   Trials

Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease

(2021) Qiu-Ling Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Cholesterol metabolism related genes in osteoarthritis

(2021) Ioanna Papathanasiou et al.   BONE

Colchicine protects against cartilage degeneration by inhibiting MMP13 expression via PLC-γ1 phosphorylation

(2021) K. Takeuchi et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis?

(2021) Amanda Thomson et al.   Frontiers in Immunology

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

(2021) Taku Ebata et al.   iScience

MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis

(2021) Bowei Ni et al.   Oxidative Medicine and Cellular Longevity

Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA

(2020) C. Aulin et al.   OSTEOARTHRITIS AND CARTILAGE

Crosstalk between gut microbiota and osteoarthritis: A critical view

(2020) Oleksandr Korotkyi et al.   Journal of Functional Foods

Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis

(2020) Masanari Hamasaki et al.   Scientific Reports

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

(2020) Eléonore Beurel et al.   NEURON

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

(2020) Ching-Heng Chou et al.   Scientific Reports

Glycyrrhizin, an HMGB1 inhibitor, Suppresses Interleukin-1β-Induced Inflammatory Responses in Chondrocytes from Patients with Osteoarthritis

(2020) Shifeng Zhou et al.   Cartilage

Platelet-rich plasma promotes recruitment of macrophages in the process of tendon healing

(2020) Hirofumi Nishio et al.   Regenerative Therapy

Association of menopause symptoms with depressive symptom severity in a diverse community-based sample

(2020) Xincheng Ji et al.   MATURITAS

A Novel Cartilage Fragments Stimulation Model Revealed that Macrophage Inflammatory Response Causes an Upregulation of Catabolic Factors of Chondrocytes In Vitro

(2019) Masanari Hamasaki et al.   Cartilage

Modifiable risk factors in knee osteoarthritis: treatment implications

(2019) Tsvetoslav Georgiev et al.   RHEUMATOLOGY INTERNATIONAL

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats

(2019) Oleksandr Korotkyi et al.   MINERVA BIOTECNOLOGICA

Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity

(2019) Jaqueline Lourdes Rios et al.   Scientific Reports

Type II collagen peptide Coll2-1 is an actor of synovitis

(2019) C. Lambert et al.   OSTEOARTHRITIS AND CARTILAGE

Gut microbiota and obesity-associated osteoarthritis

(2019) Y. Liu et al.   OSTEOARTHRITIS AND CARTILAGE

The Role of Inflammation in Depression and Fatigue

(2019) Chieh-Hsin Lee et al.   Frontiers in Immunology

Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis

(2019) Bartijn C. H. Pieters et al.   Frontiers in Immunology

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis

(2018) Sophie Jane Gilbert et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

NLRP1 and NLRP3 inflammasomes mediate LPS/ATP‑induced pyroptosis in knee osteoarthritis

(2018) Ling‑Rui Zhao et al.   Molecular Medicine Reports

Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?

(2018) M. H. J. van den Bosch   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Ethyl pyruvate ameliorates inflammatory arthritis in mice

(2017) Seung Min Jung et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cholesterol metabolism in pathogenesis of osteoarthritis disease

(2017) Saba Farnaghi et al.   International Journal of Rheumatic Diseases

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

(2017) Ragini Srivastava et al.   International Journal of Rheumatic Diseases

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

(2017) John H. Rosenberg et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fine tuning of immunometabolism for the treatment of rheumatic diseases

(2017) Jillian P. Rhoads et al.   Nature Reviews Rheumatology

Dietary Fat Intake and Radiographic Progression of Knee Osteoarthritis: Data From the Osteoarthritis Initiative

(2017) Bing Lu et al.   ARTHRITIS CARE & RESEARCH

The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial

(2017) M. Lei et al.   Beneficial Microbes

Cellular senescence in aging and osteoarthritis

(2016) Wei Seong Toh et al.   Acta Orthopaedica

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

(2016) Maryam Rahmati et al.   BONE

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

HMGB1: A critical mediator for oxidized-low density lipoproteins induced atherosclerosis

(2016) Qin Zhou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

The danger from within: alarmins in arthritis

(2016) Meriam Nefla et al.   Nature Reviews Rheumatology

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation

(2016) Z.Y. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet

(2016) Hailun Gu et al.   Nutrients

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

The Gut Microbiota in Immune-Mediated Inflammatory Diseases

(2016) Jessica D. Forbes et al.   Frontiers in Microbiology

Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

(2016) Aline Ignacio et al.   Frontiers in Immunology

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis

(2015) R F Schelbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Exercise for osteoarthritis of the knee: a Cochrane systematic review

(2015) Marlene Fransen et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Synovial Fluid HMGB-1 Levels are Associated with Osteoarthritis Severity

(2015) Xueru Ke et al.   Clinical Laboratory

Biological Therapies in Osteoarthritis

(2015) Claire Wenham et al.   CURRENT PHARMACEUTICAL DESIGN

Does lipopolysaccharide-mediated inflammation have a role in OA?

(2015) Zeyu Huang et al.   Nature Reviews Rheumatology

Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial

(2015) Ying-Ying Leung et al.   Trials

Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes

(2015) Hyun Sook Hwang et al.   ARTHRITIS RESEARCH & THERAPY

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis

(2015) Martijn H. van den Bosch et al.   Arthritis & Rheumatology

Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management

(2015) Evanthia Diamanti-Kandarakis et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Type II collagen peptide stimulates Akt leading to nuclear factor-κB activation: Its inhibition by hyaluronan

(2014) Tadashi YASUDA   BIOMEDICAL RESEARCH-TOKYO

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Unknown

(2014) Melinda Magna et al.   MOLECULAR MEDICINE

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

(2014) H. Bliddal et al.   Obesity Reviews

Probiotics Protect Mice from Ovariectomy-Induced Cortical Bone Loss

(2014) Claes Ohlsson et al.   PLoS One

Aging and Oxidative Stress Reduce the Response of Human Articular Chondrocytes to Insulin-like Growth Factor 1 and Osteogenic Protein 1

(2014) Richard F. Loeser et al.   Arthritis & Rheumatology

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9

(2013) Yoichiro Hirata et al.   ATHEROSCLEROSIS

S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis

(2013) Li-chun Wang et al.   BIOMARKERS

Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis

(2013) Daniel Leong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

(2013) Amy L. McNulty et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

(2013) L. Gallelli et al.   OSTEOARTHRITIS AND CARTILAGE

Methotrexate for pain relief in knee osteoarthritis: an open-label study

(2013) C. Y. J. Wenham et al.   RHEUMATOLOGY

The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis

(2013) Joseph A. Buckwalter et al.   Cartilage

Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE)

(2013) D. Justin Larkin et al.   Frontiers in Physiology

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

The growing array of innate inflammatory ignition switches in osteoarthritis

(2012) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

S100 proteins in cartilage: Role in arthritis

(2012) Raghunatha R. Yammani   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Osteoarthritis, inflammation and obesity

(2012) Francis Berenbaum et al.   CURRENT OPINION IN RHEUMATOLOGY

Priming Effect of Fibronectin Fragments on the Macrophage Inflammatory Response: Potential Contribution to Periodontitis

(2012) Karine Feghali et al.   INFLAMMATION

Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury

(2012) Marco Bigoni et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Syndecans in cartilage breakdown and synovial inflammation

(2012) Thomas Pap et al.   Nature Reviews Rheumatology

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

HMGB1 and Microparticles as Mediators of the Immune Response to Cell Death

(2011) David S. Pisetsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Unknown

(2011) Hanna Schierbeck et al.   MOLECULAR MEDICINE

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

(2011) Anna E. Denoble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Crystals, inflammation, and osteoarthritis

(2010) Ann K Rosenthal   CURRENT OPINION IN RHEUMATOLOGY

Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines

(2010) Sarika Amdekar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid

(2010) Nobuyuki Kumahashi et al.   KNEE

Osteoarthritis: Another Component of Metabolic Syndrome?

(2010) Manuel T. Velasquez et al.   Metabolic Syndrome and Related Disorders

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Lipid metabolism and osteoarthritis: Lessons from atherosclerosis

(2010) Vasiliki Gkretsi et al.   PROGRESS IN LIPID RESEARCH

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis

(2009) M. Blagojevic et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients

(2008) Xiao Xiang Yan et al.   ATHEROSCLEROSIS

Articular cartilage: structure, injuries and review of management

(2008) A. M. Bhosale et al.   BRITISH MEDICAL BULLETIN

Obesity and the musculoskeletal system

(2008) Ananthila Anandacoomarasamy et al.   CURRENT OPINION IN RHEUMATOLOGY